UBE2D1 and TRIM25

Number of citations of the paper that reports this interaction (PMID 22350887)
4

Data Source:
BioGRID (pull down, pull down)

		UBE2D1	TRIM25
Gene Name		ubiquitin-conjugating enzyme E2D 1	tripartite motif containing 25
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Cytosol Protein Complex	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin Conjugating Enzyme Activity	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Polyubiquitination Mitotic Cell Cycle Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression BMP Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K48-linked Ubiquitination Cellular Response To Hypoxia	Viral Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Response To Vitamin D Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Estrogen Innate Immune Response Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell
Pathways		Loss of Function of TGFBR2 in Cancer Phosphorylation of the APC/C Negative regulators of RIG-I/MDA5 signaling Cellular Senescence SMAD2/3 MH2 Domain Mutants in Cancer APC/C:Cdc20 mediated degradation of Securin Downregulation of SMAD2/3:SMAD4 transcriptional activity Signaling by BMP Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer TRIF-mediated TLR3/TLR4 signaling Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Loss of Function of SMAD4 in Cancer Senescence-Associated Secretory Phenotype (SASP) TGFBR1 KD Mutants in Cancer APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System Cellular response to hypoxia APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Regulation of Hypoxia-inducible Factor (HIF) by oxygen Separation of Sister Chromatids Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Inactivation of APC/C via direct inhibition of the APC/C complex Mitotic Anaphase TGFBR1 LBD Mutants in Cancer M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Activated TLR4 signalling Class I MHC mediated antigen processing & presentation Innate Immune System Loss of Function of SMAD2/3 in Cancer IKK complex recruitment mediated by RIP1 TGFBR2 Kinase Domain Mutants in Cancer MyD88-independent cascade Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Regulation of mitotic cell cycle Cell Cycle Checkpoints SMAD4 MH2 Domain Mutants in Cancer	Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Interferon gamma signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Innate Immune System
Drugs
Diseases
GWAS		Brain imaging ( 20100581) Crohn's disease ( 21102463)	Height ( 18391951)
Protein-Protein Interactions		193 interactors: AMFR ANAPC11 ANXA1 ANXA7 AREL1 ARIH1 ARIH2 ASB2 ASB4 ASB9 BARD1 BFAR BIRC2 BIRC3 BIRC6 BIRC7 BIRC8 BRCA1 BRCC3 BRE BRMS1 C7orf25 CADPS2 CBL CBLC CDK7 CDKN1A CHFR CNOT4 CREBBP CRYAB CTNNB1 CUL2 CUL3 DDX58 DTL DTX1 DTX2 DTX3 DTX3L DZIP3 EP300 EPS15 F12 FAF2 FBXO2 FBXW7 FOS FZR1 GADD45A GSK3B HDAC6 HERC3 HERC5 HIF1A HSD17B10 HUWE1 KAT2B KDM2B KLHL13 KLHL2 KLHL9 LRSAM1 MAP3K1 MARCH1 MARCH2 MARCH4 MARCH5 MARCH7 MARCH8 MDM2 MDM4 MGRN1 MIB1 MID1 MID2 MKNK1 MKRN2 MKRN3 MUL1 MYLIP NBN NEDD4 NEDD4L NEURL1 NFKBIA NHLRC1 NR1H2 OTUB1 PELI1 PJA2 POLL POLM RABGEF1 RAD23A RBX1 RELA RFFL RFWD2 RFWD3 RING1 RLIM RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF125 RNF126 RNF128 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF182 RNF185 RNF2 RNF25 RNF26 RNF31 RNF38 RNF4 RNF43 RNF5 RNF6 RNF7 RNF8 SH3RF1 SIAH1 SIAH2 SIRT6 SIVA1 SKP1 SMURF2 STAM2 STUB1 TAF1D TBL1X TNFAIP3 TNNT1 TOM1 TOPORS TP53 TRAF2 TRAF6 TRAF7 TRAIP TRIM10 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM31 TRIM32 TRIM35 TRIM37 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM55 TRIM63 TRIM7 TRIM8 TRIP12 TSC22D1 UBA1 UBA6 UBASH3B UBC UBE3A UBE3C UBE4A UBOX5 UFM1 UHRF2 VHL XIAP ZNRF1 ZNRF2 ZNRF4	27 interactors: AMFR DDX58 ERCC2 ESR1 GATA1 GRIK2 MEIS2 OTUB2 PITX2 RARRES3 RBCK1 RNF31 SFN STK38 TFG TRAF6 TRIM8 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L6 UBE2N USP15 USP39 ZNF24
Entrez ID		7321	7706
HPRD ID		04267	02711
Ensembl ID		ENSG00000072401	ENSG00000121060
Uniprot IDs		P51668	Q14258
PDB IDs		2C4P 2YHO 3OJ4 3PTF 4AP4
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Catabolic Process Cellular Metabolic Process Cellular Macromolecule Catabolic Process Protein Autoubiquitination Proteolysis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Monoubiquitination Cellular Response To Stress Metabolic Process Regulation Of Protein Metabolic Process Response To Stress Protein K48-linked Ubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Proteasomal Protein Catabolic Process Programmed Cell Death Cell Death Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Ubiquitination Negative Regulation Of Viral Release From Host Cell Regulation Of Viral Release From Host Cell Cellular Process Protein K63-linked Ubiquitination Regulation Of Signal Transduction Regulation Of Metabolic Process Cellular Response To Stimulus Regulation Of Apoptotic Process Innate Immune Response Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Stimulus Regulation Of Signaling	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Organic Substance Activation Of Innate Immune Response Proteolysis Immune Response-regulating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Protein Modification Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K48-linked Ubiquitination Toll-like Receptor Signaling Pathway Immune System Process Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Signaling Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Proteasomal Protein Catabolic Process Cell Communication Response To Stimulus Cellular Response To Stimulus Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway Signal Transduction Cellular Metabolic Process Negative Regulation Of Gene Expression MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Transcription, DNA-templated Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Organic Substance
Tagcloud ?		accumulation apoptosis apoptotic arsenic cadmium conjugating degradation downregulation elevated enzymes family hand induce inorganic mercury p53 promote proteasomal proximal rat suppressed suppression tubular ubiquitin ubiquitination	accelerates amf autocrine catalyzes cooperates cooperative dhfr e4 erad gauges gp78 illustrated insight isomerase ligase mechanistic motility pgi phosphoglucose polyubiquitylation round steady tripartite ub ubiquitin ubiquitylates ubiquitylation uncovers vital
Tagcloud (Difference) ?		accumulation apoptosis apoptotic arsenic cadmium conjugating degradation downregulation elevated enzymes family hand induce inorganic mercury p53 promote proteasomal proximal rat suppressed suppression tubular ubiquitination	accelerates amf autocrine catalyzes cooperates cooperative dhfr e4 erad gauges gp78 illustrated insight isomerase ligase mechanistic motility pgi phosphoglucose polyubiquitylation round steady tripartite ub ubiquitylates ubiquitylation uncovers vital
Tagcloud (Intersection) ?		ubiquitin