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UBE2D1 and MID2
Number of citations of the paper that reports this interaction (PMID
21143188
)
10
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
UBE2D1
MID2
Gene Name
ubiquitin-conjugating enzyme E2D 1
midline 2
Image
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleoplasm
Cytoplasm
Cytosol
Protein Complex
Cytoplasm
Microtubule
Extracellular Vesicular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Microtubule Binding
Zinc Ion Binding
Ligase Activity
Protein Homodimerization Activity
Protein Heterodimerization Activity
Phosphoprotein Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Protein Polyubiquitination
Mitotic Cell Cycle
Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Ubiquitin-dependent Protein Catabolic Process
Mitotic Spindle Assembly Checkpoint
Transforming Growth Factor Beta Receptor Signaling Pathway
Gene Expression
BMP Signaling Pathway
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Innate Immune Response
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Protein K48-linked Ubiquitination
Cellular Response To Hypoxia
Protein Ubiquitination
Negative Regulation Of Viral Transcription
Protein Localization To Microtubule
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Negative Regulation Of Viral Entry Into Host Cell
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Viral Release From Host Cell
Pathways
Loss of Function of TGFBR2 in Cancer
Phosphorylation of the APC/C
Negative regulators of RIG-I/MDA5 signaling
Cellular Senescence
SMAD2/3 MH2 Domain Mutants in Cancer
APC/C:Cdc20 mediated degradation of Securin
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Signaling by BMP
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Generic Transcription Pathway
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TRIF-mediated TLR3/TLR4 signaling
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Loss of Function of SMAD4 in Cancer
Senescence-Associated Secretory Phenotype (SASP)
TGFBR1 KD Mutants in Cancer
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Mitotic Metaphase and Anaphase
Adaptive Immune System
Cellular response to hypoxia
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Antigen processing: Ubiquitination & Proteasome degradation
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
Separation of Sister Chromatids
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Inactivation of APC/C via direct inhibition of the APC/C complex
Mitotic Anaphase
TGFBR1 LBD Mutants in Cancer
M Phase
Inactivation of APC/C via direct inhibition of the APC/C complex
Autodegradation of Cdh1 by Cdh1:APC/C
Mitotic Spindle Checkpoint
Activated TLR4 signalling
Class I MHC mediated antigen processing & presentation
Innate Immune System
Loss of Function of SMAD2/3 in Cancer
IKK complex recruitment mediated by RIP1
TGFBR2 Kinase Domain Mutants in Cancer
MyD88-independent cascade
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Cell Cycle, Mitotic
Loss of Function of TGFBR1 in Cancer
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Toll-Like Receptors Cascades
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Regulation of mitotic cell cycle
Cell Cycle Checkpoints
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Brain imaging (
20100581
)
Crohn's disease (
21102463
)
Protein-Protein Interactions
193 interactors:
AMFR
ANAPC11
ANXA1
ANXA7
AREL1
ARIH1
ARIH2
ASB2
ASB4
ASB9
BARD1
BFAR
BIRC2
BIRC3
BIRC6
BIRC7
BIRC8
BRCA1
BRCC3
BRE
BRMS1
C7orf25
CADPS2
CBL
CBLC
CDK7
CDKN1A
CHFR
CNOT4
CREBBP
CRYAB
CTNNB1
CUL2
CUL3
DDX58
DTL
DTX1
DTX2
DTX3
DTX3L
DZIP3
EP300
EPS15
F12
FAF2
FBXO2
FBXW7
FOS
FZR1
GADD45A
GSK3B
HDAC6
HERC3
HERC5
HIF1A
HSD17B10
HUWE1
KAT2B
KDM2B
KLHL13
KLHL2
KLHL9
LRSAM1
MAP3K1
MARCH1
MARCH2
MARCH4
MARCH5
MARCH7
MARCH8
MDM2
MDM4
MGRN1
MIB1
MID1
MID2
MKNK1
MKRN2
MKRN3
MUL1
MYLIP
NBN
NEDD4
NEDD4L
NEURL1
NFKBIA
NHLRC1
NR1H2
OTUB1
PELI1
PJA2
POLL
POLM
RABGEF1
RAD23A
RBX1
RELA
RFFL
RFWD2
RFWD3
RING1
RLIM
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF125
RNF126
RNF128
RNF13
RNF130
RNF14
RNF150
RNF165
RNF166
RNF167
RNF181
RNF182
RNF185
RNF2
RNF25
RNF26
RNF31
RNF38
RNF4
RNF43
RNF5
RNF6
RNF7
RNF8
SH3RF1
SIAH1
SIAH2
SIRT6
SIVA1
SKP1
SMURF2
STAM2
STUB1
TAF1D
TBL1X
TNFAIP3
TNNT1
TOM1
TOPORS
TP53
TRAF2
TRAF6
TRAF7
TRAIP
TRIM10
TRIM17
TRIM2
TRIM21
TRIM23
TRIM25
TRIM26
TRIM27
TRIM28
TRIM31
TRIM32
TRIM35
TRIM37
TRIM38
TRIM39
TRIM43
TRIM45
TRIM5
TRIM50
TRIM55
TRIM63
TRIM7
TRIM8
TRIP12
TSC22D1
UBA1
UBA6
UBASH3B
UBC
UBE3A
UBE3C
UBE4A
UBOX5
UFM1
UHRF2
VHL
XIAP
ZNRF1
ZNRF2
ZNRF4
108 interactors:
ADAMTSL4
AEN
AQP1
ATRIP
BCL6B
BRCA1
BRMS1L
BYSL
C19orf66
CALCOCO2
CBX8
CCDC120
CCDC42
CCHCR1
CEP57L1
CHD2
CTSZ
DCX
DGCR6
DGCR6L
DIEXF
DMRT3
DYDC1
FAM107A
FAM161A
FAM214A
FAM90A1
FARS2
FBF1
FBXL18
FRMD6
GFI1B
GMCL1
GOLGA2
GORASP2
HOXB9
IGBP1
ISCU
JOSD1
KIAA1683
KIF1A
KIFC3
LENG1
LGALS14
LGALS8
MAGOHB
METTL17
MFAP1
MID1
MID1IP1
MOS
MVP
NR1D2
NXF1
OTUB2
PPP1R18
PRPF31
PSMA1
PTCD2
RCOR3
RPH3AL
RPP25L
RUNX1T1
SCNM1
SDCBP
SLC25A48
SLC25A6
SNAI1
SNAP47
SPATA24
SPG21
SPRY2
STX11
SYT17
TCEA2
TCEB3
THAP7
TOP3B
TRIM27
TRIM29
TRIM32
TRIM42
TRIM54
TRPV6
TSGA10
UBE2D1
UBE2D4
UBE2E2
UBE2E3
UBE2U
UBTD1
UNC45A
UTP23
WT1-AS
ZBTB24
ZC2HC1C
ZFYVE21
ZGPAT
ZNF165
ZNF24
ZNF250
ZNF417
ZNF440
ZNF564
ZNF587
ZNF785
ZNF792
ZSCAN12
Entrez ID
7321
11043
HPRD ID
04267
02191
Ensembl ID
ENSG00000072401
Uniprot IDs
P51668
Q9UJV3
PDB IDs
2C4P
2YHO
3OJ4
3PTF
4AP4
2DJA
2DMK
Enriched GO Terms of Interacting Partners
?
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Protein Polyubiquitination
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Metabolic Process
Cellular Macromolecule Catabolic Process
Protein Autoubiquitination
Proteolysis
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Protein Monoubiquitination
Cellular Response To Stress
Metabolic Process
Regulation Of Protein Metabolic Process
Response To Stress
Protein K48-linked Ubiquitination
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Proteasomal Protein Catabolic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Protein Ubiquitination
Negative Regulation Of Viral Release From Host Cell
Regulation Of Viral Release From Host Cell
Cellular Process
Protein K63-linked Ubiquitination
Regulation Of Signal Transduction
Regulation Of Metabolic Process
Cellular Response To Stimulus
Regulation Of Apoptotic Process
Innate Immune Response
Regulation Of Cell Death
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Response To Stimulus
Regulation Of Signaling
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Gene Expression
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Transcription, DNA-templated
Nitrogen Compound Metabolic Process
RNA Biosynthetic Process
Protein Polyubiquitination
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Protein K63-linked Ubiquitination
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Protein K48-linked Ubiquitination
Negative Regulation Of Nucleic Acid-templated Transcription
Biosynthetic Process
Cellular Process
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Negative Regulation Of Cellular Metabolic Process
Protein K11-linked Ubiquitination
Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Maturation Of SSU-rRNA
Cellular Metabolic Process
Negative Regulation Of Microtubule Depolymerization
Protein K6-linked Ubiquitination
Regulation Of Microtubule-based Process
Ribosomal Small Subunit Biogenesis
Regulation Of Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Microtubule Polymerization Or Depolymerization
Synaptic Vesicle Fusion To Presynaptic Membrane
Negative Regulation Of Transferase Activity
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Viral Release From Host Cell
Negative Regulation Of Protein Tyrosine Kinase Activity
Regulation Of Microtubule Cytoskeleton Organization
Regulation Of Viral Transcription
Regulation Of Histone H3-K4 Methylation
Regulation Of Microtubule Polymerization Or Depolymerization
Tagcloud
?
accumulation
apoptosis
apoptotic
arsenic
cadmium
conjugating
degradation
downregulation
elevated
enzymes
family
hand
induce
inorganic
mercury
p53
promote
proteasomal
proximal
rat
suppressed
suppression
tubular
ubiquitin
ubiquitination
Tagcloud (Difference)
?
accumulation
apoptosis
apoptotic
arsenic
cadmium
conjugating
degradation
downregulation
elevated
enzymes
family
hand
induce
inorganic
mercury
p53
promote
proteasomal
proximal
rat
suppressed
suppression
tubular
ubiquitin
ubiquitination
Tagcloud (Intersection)
?