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UBE2D1 and FZR1
Number of citations of the paper that reports this interaction (PubMedID
18485873
)
31
Data Source:
BioGRID
(pull down)
UBE2D1
FZR1
Description
ubiquitin conjugating enzyme E2 D1
fizzy and cell division cycle 20 related 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytoplasm
Cytosol
Nuclear Membrane
Molecular Function
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Protein Binding
Anaphase-promoting Complex Binding
Ubiquitin-protein Transferase Activator Activity
Ubiquitin-like Ligase-substrate Adaptor Activity
Ubiquitin Ligase Activator Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Negative Regulation Of BMP Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Cellular Response To Nutrient Levels
TORC1 Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Positive Regulation Of Protein Polyubiquitination
Negative Regulation Of TORC1 Signaling
DNA Repair
DNA Damage Response
Mitotic G2 DNA Damage Checkpoint Signaling
Regulation Of Mitotic Cell Cycle
Positive Regulation Of Cell Population Proliferation
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
Regulation Of Meiotic Nuclear Division
Thymidine Biosynthetic Process
Cell Division
Regulation Of Meiotic Cell Cycle
Proteolysis Involved In Protein Catabolic Process
Lens Fiber Cell Differentiation
Protein K11-linked Ubiquitination
Positive Regulation Of Ubiquitin Protein Ligase Activity
DNA Synthesis Involved In Mitotic DNA Replication
Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Negative Regulation Of Cellular Senescence
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Inactivation of APC/C via direct inhibition of the APC/C complex
TICAM1, RIP1-mediated IKK complex recruitment
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Signaling by BMP
Downstream TCR signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
Regulation of TNFR1 signaling
CLEC7A (Dectin-1) signaling
Ovarian tumor domain proteases
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Inactivation of CSF3 (G-CSF) signaling
Antigen processing: Ubiquitination & Proteasome degradation
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of Emi1
Senescence-Associated Secretory Phenotype (SASP)
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Brain imaging (
20100581
)
Crohn's disease (
21102463
)
Red cell distribution width (
32888494
)
Interacting Genes
239 interacting genes:
AMFR
ANAPC11
ANXA1
ANXA7
AREL1
ARIH1
ARIH2
ARK2C
ARRDC3
ASB2
ASB4
ASB9
BABAM2
BARD1
BFAR
BIRC2
BIRC3
BIRC6
BIRC7
BIRC8
BRCA1
BRCC3
BRMS1
C7orf25
CADPS2
CBL
CBLC
CDK7
CDKN1A
CHFR
CNOT4
COP1
CRBN
CREBBP
CRYAB
CTNNB1
CUL2
CUL3
CUL4A
DTL
DTX1
DTX2
DTX3
DTX3L
DYRK2
DZIP3
EP300
EPS15
F12
FAF2
FBXL2
FBXL20
FBXO2
FBXO7
FOS
FZR1
GADD45A
GSK3B
HDAC6
HECTD1
HECW1
HERC2
HERC3
HIF1A
HSD17B10
HUWE1
ITCH
KAT2B
KCTD17
KDM2B
KEAP1
KLHL13
KLHL2
KLHL9
LNPK
LRR1
LRSAM1
LTN1
MAP3K1
MARCHF1
MARCHF2
MARCHF4
MARCHF5
MARCHF7
MARCHF8
MDM2
MDM4
MEOX2
MGRN1
MIB1
MIB2
MID1
MID2
MKNK1
MKRN1
MKRN2
MKRN3
MUL1
NBN
NEDD4
NEDD4L
NEURL1
NFKBIA
NHLRC1
NQO1
NR1H2
OBI1
PELI1
PJA2
PMAIP1
POLL
POLM
POLR2E
PRKN
RABGEF1
RAG1
RBCK1
RBX1
RCHY1
RELA
RFFL
RFWD3
RIGI
RING1
RLIM
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF123
RNF125
RNF126
RNF13
RNF130
RNF14
RNF144A
RNF150
RNF166
RNF167
RNF168
RNF181
RNF182
RNF185
RNF2
RNF207
RNF216
RNF25
RNF26
RNF31
RNF34
RNF38
RNF4
RNF43
RNF5
RNF6
RNF7
RNF8
SH3RF1
SHPRH
SIAH1
SIAH2
SIRT6
SIVA1
SKP1
SMURF1
SPOP
STAM2
STUB1
TAF1D
TBL1X
TMEM129
TNFAIP3
TNNT1
TOM1
TOPORS
TRAF2
TRAF4
TRAF6
TRAF7
TRAIP
TRIM10
TRIM17
TRIM21
TRIM22
TRIM23
TRIM24
TRIM25
TRIM26
TRIM27
TRIM28
TRIM3
TRIM31
TRIM32
TRIM35
TRIM37
TRIM38
TRIM39
TRIM41
TRIM43
TRIM45
TRIM5
TRIM50
TRIM54
TRIM55
TRIM62
TRIM63
TRIM69
TRIM7
TRIM72
TRIM8
TRIP12
TSC22D1
UBA1
UBA6
UBASH3B
UBC
UBE3A
UBE3C
UBE4A
UBOX5
UBR5
UBTD1
UFM1
UHRF1
UHRF2
USP21
UVSSA
VHL
WWP1
WWP2
XIAP
ZNF598
ZNRF1
ZNRF2
ZNRF4
ZRANB1
95 interacting genes:
AKT1S1
ANAPC1
ANAPC11
ANAPC2
ANAPC7
ANLN
ARNT
BECN1
BEX1
BLID
BTRC
C7orf25
CCL5
CCNA1
CCNB1
CCND2
CCNE1
CCNF
CDC14A
CDC27
CDC6
CDK2
CDK4
CDK5
CDK6
CDKN2B
CDR2
CDT1
CLSPN
CYP17A1
DCPS
DKK3
DNAJA1
DNM1L
DTYMK
E2F3
EPHA2
EPSTI1
ERBB2
FBXO5
FGFR4
GLIS2
GMNN
HECW2
HIF1A
ID2
KAT2A
KIF18B
LATS2
MAD2L2
MAK
MAP2K3
MAP2K5
MAP3K5
MAPK8
MET
MOAP1
MTA3
MYC
NAT2
NEDD9
NEK2
NF2
OTUD7B
PAX3
PDGFRA
PSMC3IP
PTP4A3
PTTG1
RASSF1
RB1
RBBP8
SASS6
SENP2
SIRT1
SIRT2
SKIL
SKP2
SMURF1
SOX2
SOX4
SRC
STK11
TBK1
TEAD2
TERT
THRSP
TK1
TTF2
UBC
UBE2D1
UBE2D3
UBE2K
UHRF1
USP10
Entrez ID
7321
51343
HPRD ID
04267
04687
Ensembl ID
ENSG00000072401
ENSG00000105325
Uniprot IDs
A0A087WW00
P51668
Q9UM11
PDB IDs
2C4P
2YHO
3OJ4
3PTF
4AP4
4QPL
5FER
5TUT
6D4P
7ZJ3
4UI9
5L9T
5L9U
8TAR
8TAU
9GAW
Enriched GO Terms of Interacting Partners
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Ubiquitin Protein Ligase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Modification Process
Protein Polyubiquitination
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Transferase Activity
Macromolecule Catabolic Process
Zinc Ion Binding
Macromolecule Metabolic Process
Proteolysis
Catabolic Process
Protein Catabolic Process
Proteasomal Protein Catabolic Process
Metal Ion Binding
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Protein K63-linked Ubiquitination
Cytoplasm
Protein Monoubiquitination
Response To Stress
Ubiquitin Ligase Complex
Cellular Response To Stress
Ubiquitin Protein Ligase Binding
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signal Transduction
Regulation Of Post-translational Protein Modification
Cytosol
Immune System Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Innate Immune Response
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Ubiquitination
Canonical NF-kappaB Signal Transduction
DNA Damage Response
Regulation Of Protein Ubiquitination
Positive Regulation Of Post-translational Protein Modification
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Binding
Regulation Of Cell Cycle
Regulation Of Cell Cycle Process
Cell Division
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Nucleoplasm
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Nucleus
Regulation Of Primary Metabolic Process
Cytoplasm
Regulation Of Chromosome Segregation
Cytosol
Regulation Of Chromosome Organization
Regulation Of Sister Chromatid Segregation
Regulation Of Metabolic Process
Regulation Of Protein Modification Process
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Modification Process
Negative Regulation Of Cell Cycle
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Kinase Activity
Positive Regulation Of Cell Cycle Phase Transition
Spindle
Protein Kinase Activity
Regulation Of Organelle Organization
Negative Regulation Of Metabolic Process
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cell Cycle Process
Post-translational Protein Modification
Negative Regulation Of Macromolecule Metabolic Process
Modification-dependent Protein Catabolic Process
Intracellular Signal Transduction
Regulation Of Cellular Component Organization
Positive Regulation Of Cell Population Proliferation
Cellular Response To Stress
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of RNA Metabolic Process
Transferase Activity
Positive Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Process
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Tagcloud (Intersection)
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