TPM3 and TFPT

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		TPM3	TFPT
Gene Name		tropomyosin 3	TCF3 (E2A) fusion partner (in childhood Leukemia)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Podosome Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Growth Cone Cortical Cytoskeleton Filamentous Actin Cleavage Furrow Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Actin Filament Ino80 Complex Nuclear Membrane
	Molecular Function	Molecular_function Actin Binding	DNA Binding Protein Binding Protein Kinase Binding Protein Heterodimerization Activity
	Biological Process	Movement Of Cell Or Subcellular Component Muscle Contraction Muscle Filament Sliding	DNA Repair DNA Recombination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Apoptotic Process Apoptotic Signaling Pathway
Pathways		Striated Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		41 interactors: ACTA1 ACTB BLOC1S6 C1orf216 CCDC102B CCDC114 CCDC146 CCHCR1 CNN1 FAM9C FBXO5 HDDC3 HSF2 IFIT3 IKBIP KCNE1 KIFC3 KXD1 LCA5L LURAP1 MAD1L1 MAGEA11 NEK2 OIP5 PBX3 S100A2 S100A4 SMAD3 SUMO4 SYCE1 TFPT THAP1 TLK1 TMOD1 TMOD2 TNNT1 TRAP1 TRIM27 TRIP6 VPS52 WASH3P	23 interactors: APP C4orf46 CCDC67 CDCA7L DYDC1 EAF1 EAF2 ELL HAUS1 KRT19 LMO2 NOL3 PAWR PIM1 RALBP1 RPGRIP1 RUNDC3A SDCCAG3 STK3 TCF3 TFIP11 TPM1 TPM3
Entrez ID		7170	29844
HPRD ID		01840	10266
Ensembl ID		ENSG00000143549	ENSG00000105619
Uniprot IDs		B4DQ80 P06753 Q5VU58 Q5VU63 Q8TCG3	P0C1Z6
PDB IDs
Enriched GO Terms of Interacting Partners?		Actomyosin Structure Organization Organelle Organization Actin Filament-based Process Regulation Of Organelle Organization Cellular Component Assembly Actin-myosin Filament Sliding Muscle Filament Sliding Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Actin-mediated Cell Contraction Regulation Of Cytoskeleton Organization Actin Filament Organization Actin Filament-based Movement Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Pointed-end Actin Filament Capping Regulation Of Chromosome Segregation Regulation Of Actin Polymerization Or Depolymerization Myofibril Assembly Regulation Of Actin Filament Length Cell-cell Junction Organization Regulation Of Mitotic Cell Cycle Muscle Contraction Cell Division Cell Cycle Muscle System Process Organelle Assembly Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Cell Development Movement Of Cell Or Subcellular Component Mitotic Nuclear Division Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Regulation Of Muscle Contraction Positive Regulation Of Transcription Factor Import Into Nucleus Striated Muscle Cell Development Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Transforming Growth Factor Beta3 Production Inhibition Of APC-Cdc20 Complex Activity Regulation Of Metaphase Plate Congression Posterior Compartment Specification Anterior Compartment Pattern Formation Negative Regulation Of Cytoskeleton Organization Regulation Of Mitotic Sister Chromatid Separation Arp2/3 Complex-mediated Actin Nucleation Muscle Cell Development Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling	Positive Regulation Of Metabolic Process Apoptotic Process RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Programmed Cell Death Regulation Of Metabolic Process Cell Death Death Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Embryo Development Regulation Of Transcription, DNA-templated Actin-myosin Filament Sliding Muscle Filament Sliding Regulation Of Nucleic Acid-templated Transcription Embryonic Hemopoiesis Regulation Of RNA Biosynthetic Process Cell Differentiation Involved In Embryonic Placenta Development Regulation Of RNA Metabolic Process Regulation Of Catalytic Activity Organelle Assembly Actin-mediated Cell Contraction Cellular Component Assembly In Utero Embryonic Development Spliceosomal Complex Disassembly Response To Injury Involved In Regulation Of Muscle Adaptation Positive Regulation Of Heart Rate By Epinephrine Sarcomere Organization Regulation Of B Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Actin Filament-based Movement Positive Regulation Of Catalytic Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Cell Cycle Actin Filament-based Process Myofibril Assembly Transcription, DNA-templated Organ Development Muscle Cell Differentiation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Collateral Sprouting In Absence Of Injury Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Tissue Development Protein Stabilization Developmental Process
Tagcloud ?		aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next ntrk1 oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput transforming trk trka trkb trkc
Tagcloud (Difference) ?		aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next ntrk1 oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput transforming trk trka trkb trkc
Tagcloud (Intersection) ?