TFPT and STK3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		TFPT	STK3
Description		TCF3 fusion partner	serine/threonine kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Ino80 Complex	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Protein-containing Complex
	Molecular Function	DNA Binding Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity Transcription Regulator Activator Activity
	Biological Process	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Apoptotic Process DNA Damage Response Regulation Of Chromosome Organization Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Apoptotic Signaling Pathway Positive Regulation Of Telomere Maintenance In Response To DNA Damage	Neural Tube Formation Endocardium Development Protein Phosphorylation Protein Import Into Nucleus Apoptotic Process Signal Transduction JNK Cascade Central Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Organ Growth Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Protein Tetramerization Centrosome Separation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Protein Localization To Centrosome Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		UCH proteinases DNA Damage Recognition in GG-NER	Signaling by Hippo
Drugs			Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661)	Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)
Interacting Genes		30 interacting genes: APP C19orf25 C4orf46 CCDC57 CCNDBP1 CDCA7L CNN1 DDIT4L DEUP1 DYDC1 EAF1 EAF2 ELL HAUS1 KRT19 LMO2 NOL3 PAWR PIM1 PIN1 PSMB1 RPGRIP1 RUNDC3A STK3 TCF3 TFIP11 TPM1 TPM2 TPM3 TRAF1	41 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GABARAP GABARAPL1 GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS2 LRRK2 MAP1LC3B MAP1LC3C MARK2 MBP MOB3B MOB4 MPP1 OGT ORM2 PEX19 PIN1 QARS1 RAF1 RASSF4 SAV1 SLMAP SNIP1 SULT2A1 TFPT TRAF1 TRIM21 TRIM69 ZC3H7A
Entrez ID		29844	6788
HPRD ID		10266	05433
Ensembl ID		ENSG00000105619	ENSG00000104375
Uniprot IDs		P0C1Z6	A0A087WZ06 A0A384MR07 Q13188
PDB IDs			3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2 8A66
Enriched GO Terms of Interacting Partners?		Muscle Thin Filament Tropomyosin Supramolecular Fiber Organization Transcription Elongation Factor Complex Actin Filament Super Elongation Complex Actin Filament Organization Structural Constituent Of Muscle Transcription Elongation By RNA Polymerase II Transcription Elongation Factor Activity Cytoskeleton Actin Cytoskeleton DNA-templated Transcription Elongation Regulation Of Extrinsic Apoptotic Signaling Pathway Cytoplasm Actin Binding Actin Filament Binding Microtubule Organizing Center Organization Regulation Of Transcription Elongation By RNA Polymerase II Apoptotic Process Protein Binding Cell Differentiation Involved In Embryonic Placenta Development Nuclear Speck Regulation Of DNA-templated Transcription Elongation Centriole Replication Programmed Cell Death Cell Death Actomyosin Structure Organization	Cellular Response To Nitrogen Starvation Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Regulation Of Hippo Signaling Cytoplasm Mitophagy Autophagosome Cellular Response To Nutrient Levels Autophagosome Assembly Vacuole Organization Cellular Response To Starvation Autophagosome Organization Regulation Of Intracellular Signal Transduction Autophagy Autophagosome Maturation Positive Regulation Of Proteolysis Intracellular Signal Transduction Autophagosome Membrane Response To Starvation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytosol Protein-containing Complex Disassembly Negative Regulation Of Hippo Signaling Hippo Signaling Apoptotic Process Macroautophagy Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Programmed Cell Death Protein Binding Cell Death Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Organ Growth Signal Transduction Protein-containing Complex Organization Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Nutrient Levels Response To Stress Negative Regulation Of Signaling Negative Regulation Of Cell Communication Pyroptotic Inflammatory Response Regulation Of Protein Metabolic Process Protein Phosphorylation Positive Regulation Of Proteasomal Protein Catabolic Process Protein Serine Kinase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?