TPM3 and KCNE1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TPM3	KCNE1
Gene Name		tropomyosin 3	potassium channel, voltage gated subfamily E regulatory beta subunit 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Podosome Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Growth Cone Cortical Cytoskeleton Filamentous Actin Cleavage Furrow Extracellular Vesicular Exosome	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Z Disc
	Molecular Function	Molecular_function Actin Binding	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Telethonin Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Movement Of Cell Or Subcellular Component Muscle Contraction Muscle Filament Sliding	Protein N-linked Glycosylation Protein O-linked Glycosylation Sensory Perception Of Sound Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To CAMP Potassium Ion Export Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		Striated Muscle Contraction Smooth Muscle Contraction
Drugs			Indapamide
Diseases
GWAS			Electrocardiographic traits ( 20062063)
Protein-Protein Interactions		41 interactors: ACTA1 ACTB BLOC1S6 C1orf216 CCDC102B CCDC114 CCDC146 CCHCR1 CNN1 FAM9C FBXO5 HDDC3 HSF2 IFIT3 IKBIP KCNE1 KIFC3 KXD1 LCA5L LURAP1 MAD1L1 MAGEA11 NEK2 OIP5 PBX3 S100A2 S100A4 SMAD3 SUMO4 SYCE1 TFPT THAP1 TLK1 TMOD1 TMOD2 TNNT1 TRAP1 TRIM27 TRIP6 VPS52 WASH3P	6 interactors: ADRB2 KCNH2 KCNQ1 PRKCA TPM3 UBASH3A
Entrez ID		7170	3753
HPRD ID		01840	01442
Ensembl ID		ENSG00000143549	ENSG00000180509
Uniprot IDs		B4DQ80 P06753 Q5VU58 Q5VU63 Q8TCG3	A7LFK2 A7LFK4 A8MWV9 C7S316 P15382 Q6FHJ6
PDB IDs			2K21
Enriched GO Terms of Interacting Partners?		Actomyosin Structure Organization Organelle Organization Actin Filament-based Process Regulation Of Organelle Organization Cellular Component Assembly Actin-myosin Filament Sliding Muscle Filament Sliding Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Actin-mediated Cell Contraction Regulation Of Cytoskeleton Organization Actin Filament Organization Actin Filament-based Movement Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Pointed-end Actin Filament Capping Regulation Of Chromosome Segregation Regulation Of Actin Polymerization Or Depolymerization Myofibril Assembly Regulation Of Actin Filament Length Cell-cell Junction Organization Regulation Of Mitotic Cell Cycle Muscle Contraction Cell Division Cell Cycle Muscle System Process Organelle Assembly Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Cell Development Movement Of Cell Or Subcellular Component Mitotic Nuclear Division Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Regulation Of Muscle Contraction Positive Regulation Of Transcription Factor Import Into Nucleus Striated Muscle Cell Development Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Transforming Growth Factor Beta3 Production Inhibition Of APC-Cdc20 Complex Activity Regulation Of Metaphase Plate Congression Posterior Compartment Specification Anterior Compartment Pattern Formation Negative Regulation Of Cytoskeleton Organization Regulation Of Mitotic Sister Chromatid Separation Arp2/3 Complex-mediated Actin Nucleation Muscle Cell Development Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling	Regulation Of Muscle Contraction Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Regulation Of Heart Contraction Positive Regulation Of Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Muscle Contraction Cardiac Muscle Cell Action Potential Involved In Contraction Activation Of Adenylate Cyclase Activity Positive Regulation Of Potassium Ion Transport Muscle System Process Positive Regulation Of Adenylate Cyclase Activity Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Blood Circulation Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Positive Regulation Of Lyase Activity Cardiac Muscle Contraction Cellular Response To Drug Regulation Of Adenylate Cyclase Activity Regulation Of Potassium Ion Transport Positive Regulation Of CAMP Biosynthetic Process Heart Contraction Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Ion Transmembrane Transport Striated Muscle Contraction Positive Regulation Of Cyclic Nucleotide Metabolic Process Action Potential Regulation Of Striated Muscle Contraction Regulation Of CAMP Biosynthetic Process Potassium Ion Export Across Plasma Membrane Negative Regulation Of Potassium Ion Export Positive Regulation Of Dense Core Granule Biogenesis Regulation Of CAMP Metabolic Process Synaptic Transmission Regulation Of Ion Transport Regulation Of Cellular Component Movement Regulation Of Heart Rate By Hormone Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Histone H3-T6 Phosphorylation Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure
Tagcloud ?		aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next ntrk1 oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput transforming trk trka trkb trkc	blockers channels coimmunoprecipitation contractions debate diversity electrophysiological exhibiting fail hek heteromers heterotetrameric heterotetramers kcne3 kv kv7 microdomains muscles myocytes oocyte photobleaching physiology raft shed smooth tune vasoconstriction vasorelaxants vessels
Tagcloud (Difference) ?		aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next ntrk1 oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput transforming trk trka trkb trkc	blockers channels coimmunoprecipitation contractions debate diversity electrophysiological exhibiting fail hek heteromers heterotetrameric heterotetramers kcne3 kv kv7 microdomains muscles myocytes oocyte photobleaching physiology raft shed smooth tune vasoconstriction vasorelaxants vessels
Tagcloud (Intersection) ?