TPM3 and TRIP6

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TPM3	TRIP6
Gene Name		tropomyosin 3	thyroid hormone receptor interactor 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Podosome Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Growth Cone Cortical Cytoskeleton Filamentous Actin Cleavage Furrow Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Interleukin-1 Receptor Complex
	Molecular Function	Molecular_function Actin Binding	Interleukin-1 Receptor Binding Protein Binding Zinc Ion Binding Kinase Binding Poly(A) RNA Binding Thyroid Hormone Receptor Binding
	Biological Process	Movement Of Cell Or Subcellular Component Muscle Contraction Muscle Filament Sliding	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Cell Migration Focal Adhesion Assembly
Pathways		Striated Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS			Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Protein-Protein Interactions		41 interactors: ACTA1 ACTB BLOC1S6 C1orf216 CCDC102B CCDC114 CCDC146 CCHCR1 CNN1 FAM9C FBXO5 HDDC3 HSF2 IFIT3 IKBIP KCNE1 KIFC3 KXD1 LCA5L LURAP1 MAD1L1 MAGEA11 NEK2 OIP5 PBX3 S100A2 S100A4 SMAD3 SUMO4 SYCE1 TFPT THAP1 TLK1 TMOD1 TMOD2 TNNT1 TRAP1 TRIM27 TRIP6 VPS52 WASH3P	105 interactors: ABI2 ADAMTSL4 AQP1 ARNT2 ATN1 ATP5O ATXN1 BCAR1 BYSL CATSPER1 CBLC CCL5 CEP57L1 CNTF CREB5 CTAG2 DHX37 DMRT3 DTX2 EXOC3-AS1 FAM124B FAM154A FAM46C FASLG FHL3 FRS3 GDPD5 GFI1B GNAI2 GSE1 HLA-DPB1 HOXA1 HOXA9 HOXB9 HYKK ILF3 INCA1 KIAA1683 KIF1A KIR2DL4 KLK15 KRTAP26-1 LMO2 LOC149950 LPAR2 MAPKBP1 MEMO1 METTL17 MSRB3 MVP NCK2 NEDD9 NEU4 NUP210 ODF1 OIP5 OTUB2 PDGFRB PDLIM4 PIN1 POM121 POM121L4P PPP1R16A PRKAA1 PRKAA2 PTK2 PTPN13 PXN RAD23A RERE RFX3 RHOA RHOQ RNF213 RNF214 SCRIB SIK3 SLC15A3 SLC25A6 SMAD1 SON SRC STAC STK16 SVIL SYNGAP1 TAB1 TCAF1 TEKT4 THRB TLR2 TMSB4X TPM3 TPM4 TRAF3IP2 TRAPPC2L TRIM29 TTLL10 TXN2 TXNDC5 VCL WT1-AS XRCC6BP1 YPEL3 ZBP1
Entrez ID		7170	7205
HPRD ID		01840	04242
Ensembl ID		ENSG00000143549	ENSG00000087077
Uniprot IDs		B4DQ80 P06753 Q5VU58 Q5VU63 Q8TCG3	F2ZC06 Q15654
PDB IDs			1X61 2DLO
Enriched GO Terms of Interacting Partners?		Actomyosin Structure Organization Organelle Organization Actin Filament-based Process Regulation Of Organelle Organization Cellular Component Assembly Actin-myosin Filament Sliding Muscle Filament Sliding Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Actin-mediated Cell Contraction Regulation Of Cytoskeleton Organization Actin Filament Organization Actin Filament-based Movement Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Pointed-end Actin Filament Capping Regulation Of Chromosome Segregation Regulation Of Actin Polymerization Or Depolymerization Myofibril Assembly Regulation Of Actin Filament Length Cell-cell Junction Organization Regulation Of Mitotic Cell Cycle Muscle Contraction Cell Division Cell Cycle Muscle System Process Organelle Assembly Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Cell Development Movement Of Cell Or Subcellular Component Mitotic Nuclear Division Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Regulation Of Muscle Contraction Positive Regulation Of Transcription Factor Import Into Nucleus Striated Muscle Cell Development Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Transforming Growth Factor Beta3 Production Inhibition Of APC-Cdc20 Complex Activity Regulation Of Metaphase Plate Congression Posterior Compartment Specification Anterior Compartment Pattern Formation Negative Regulation Of Cytoskeleton Organization Regulation Of Mitotic Sister Chromatid Separation Arp2/3 Complex-mediated Actin Nucleation Muscle Cell Development Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling	Signal Complex Assembly Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Regulation Of Signaling Actin Filament-based Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction ERBB Signaling Pathway Cell Communication Cellular Process Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Multicellular Organismal Development Regulation Of Apoptotic Process Response To Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Protein Phosphorylation Cellular Response To Stimulus Platelet Activation Response To Hormone Response To Stress Cellular Response To Growth Factor Stimulus Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Cell Death Actin Cytoskeleton Organization Wound Healing Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Organ Development Regulation Of Cell Motility Cell Motility Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process
Tagcloud ?		aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next ntrk1 oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput transforming trk trka trkb trkc	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Difference) ?		aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next ntrk1 oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput transforming trk trka trkb trkc	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Intersection) ?