TPM3 and FBXO5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TPM3	FBXO5
Description		tropomyosin 3	F-box protein 5
Image
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Mitochondrion Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Cytoskeleton Meiotic Spindle
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Protein Binding Zinc Ion Binding Anaphase-promoting Complex Binding Protein Kinase Binding Metal Ion Binding Molecular Function Inhibitor Activity Ubiquitin Ligase Inhibitor Activity
	Biological Process	Muscle Contraction Actin Filament Organization	Oocyte Maturation Regulation Of DNA Replication DNA Damage Response Spindle Assembly Involved In Female Meiosis I Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle Organization Protein Ubiquitination Negative Regulation Of DNA Endoreduplication Regulation Of Meiotic Nuclear Division Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Mitotic Metaphase/anaphase Transition Microtubule Polymerization Spindle Assembly Cell Division Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Biomineral Tissue Development Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Mesenchymal Stem Cell Migration Negative Regulation Of Cellular Senescence
Pathways		Striated Muscle Contraction Smooth Muscle Contraction RHOV GTPase cycle Signaling by ALK fusions and activated point mutants	SCF-beta-TrCP mediated degradation of Emi1 Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Mitotic Metaphase/Anaphase Transition G1/S-Specific Transcription
Drugs		Phenethyl Isothiocyanate
Diseases		Congenital fiber type disproportion (CFTD) Cap myopathy Thyroid cancer Nemaline myopathy
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Platelet count ( 27863252) Smoking initiation (ever regular vs never regular) ( 30679032) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Body mass index ( 26426971) Chronotype ( 30696823) Morning person ( 30696823) Prostate cancer ( 23535732)
Interacting Genes		60 interacting genes: ACTA1 ACTB BLOC1S6 C1orf216 CAVIN3 CCDC102B CCDC146 CCHCR1 CHRM3 CNN1 DVL2 FAM9C FBXO5 FGA FNDC3B HDDC3 HOOK2 HSF2 HSF4 IFIT3 IKBIP ISG15 KCNE1 KIFC3 KXD1 LCA5L LURAP1 MAD1L1 MAGEA11 MAST2 NEK2 NOD2 NUP54 ODAD1 OIP5 PBX3 PHLDB3 S100A2 S100A4 SMAD3 SNAPIN SUMO4 SYCE1 TAB2 TFPT THAP1 THAP7 TLK1 TMOD1 TMOD2 TNNI1 TNNT1 TRAP1 TRIM27 TRIP6 TSKS VPS52 WASH3P WASHC1 XIAP	11 interacting genes: ANAPC1 ANAPC11 ANAPC7 CDC20 CDK1 EVI5 FZR1 RAD51 SKP1 SRC TPM3
Entrez ID		7170	26271
HPRD ID		01840	09348
Ensembl ID		ENSG00000143549	ENSG00000112029
Uniprot IDs		A0A087WWU8 A0A0S2Z4G4 A0A0S2Z4G8 A0A0S2Z4I4 A0A2R2Y2Q3 B4DQ80 J3KN67 P06753	Q9UKT4
PDB IDs		6OTN	2M6N 4UI9 9GAW
Enriched GO Terms of Interacting Partners?		Cytoskeleton Striated Muscle Thin Filament Actin Filament Organization Supramolecular Fiber Organization Tropomyosin Binding Identical Protein Binding BLOC-1 Complex Centriole Arp2/3 Complex-mediated Actin Nucleation Actin Binding Muscle Contraction P38MAPK Cascade Actin Nucleation Protein K63-linked Ubiquitination Pointed-end Actin Filament Capping Regulation Of Actin Cytoskeleton Organization Muscle System Process Organelle Organization Protein Linear Polyubiquitination Phosphatidylinositol 3-kinase Inhibitor Activity Regulation Of Actin Nucleation Transition Between Fast And Slow Fiber Regulation Of Actin Filament Organization Troponin Complex Regulation Of Lysosome Size BORC Complex Regulation Of Actin Filament-based Process Microtubule-based Movement Microtubule-based Process Retrograde Transport, Endosome To Golgi Microvesicle Actin Filament-based Process Cytoskeleton Organization Regulation Of Protein Ubiquitination Actomyosin Structure Organization Regulation Of Skeletal Muscle Adaptation Regulation Of Endosome Size Cytoskeleton-dependent Intracellular Transport Regulation Of Organelle Organization Regulation Of System Process Positive Regulation Of Biomineral Tissue Development Intracellular Transport Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Vesicle Organization Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Side Of Lysosomal Membrane Lysosomal Transport Protein Kinase Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction	Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Regulation Of Meiotic Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Division Regulation Of Chromosome Organization Regulation Of Sister Chromatid Segregation Proteasomal Protein Catabolic Process Post-translational Protein Modification Protein K11-linked Ubiquitination Regulation Of Chromosome Segregation Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Ubiquitin Ligase Activator Activity Proteolysis Involved In Protein Catabolic Process Regulation Of Reproductive Process Regulation Of Organelle Organization Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Metaphase/anaphase Transition Protein Branched Polyubiquitination Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein K48-linked Ubiquitination Protein Polyubiquitination Positive Regulation Of Cell Cycle Phase Transition Protein Modification Process Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Chromosome Separation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Protein Modification By Small Protein Conjugation Proteolysis Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cytosol Positive Regulation Of Mitotic Nuclear Division Thymidine Biosynthetic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Thymidine Metabolic Process Cytoskeleton Positive Regulation Of Organelle Organization
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