TPM3 and CNN1

Number of citations of the paper that reports this interaction (PMID 2161834)
66

Data Source:
HPRD (in vitro, in vivo)

		TPM3	CNN1
Gene Name		tropomyosin 3	calponin 1, basic, smooth muscle
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Podosome Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Growth Cone Cortical Cytoskeleton Filamentous Actin Cleavage Furrow Extracellular Vesicular Exosome	Cytoskeleton Focal Adhesion
	Molecular Function	Molecular_function Actin Binding	Actin Binding Calmodulin Binding
	Biological Process	Movement Of Cell Or Subcellular Component Muscle Contraction Muscle Filament Sliding	Regulation Of Smooth Muscle Contraction Actomyosin Structure Organization
Pathways		Striated Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS
Protein-Protein Interactions		41 interactors: ACTA1 ACTB BLOC1S6 C1orf216 CCDC102B CCDC114 CCDC146 CCHCR1 CNN1 FAM9C FBXO5 HDDC3 HSF2 IFIT3 IKBIP KCNE1 KIFC3 KXD1 LCA5L LURAP1 MAD1L1 MAGEA11 NEK2 OIP5 PBX3 S100A2 S100A4 SMAD3 SUMO4 SYCE1 TFPT THAP1 TLK1 TMOD1 TMOD2 TNNT1 TRAP1 TRIM27 TRIP6 VPS52 WASH3P	9 interactors: ACTA1 ADRB2 CALM1 DNMBP FYN MYO1A PRKCE TPM3 TUBB
Entrez ID		7170	1264
HPRD ID		01840	02884
Ensembl ID		ENSG00000143549	ENSG00000130176
Uniprot IDs		B4DQ80 P06753 Q5VU58 Q5VU63 Q8TCG3	B7Z7E1 P51911
PDB IDs			1WYP
Enriched GO Terms of Interacting Partners?		Actomyosin Structure Organization Organelle Organization Actin Filament-based Process Regulation Of Organelle Organization Cellular Component Assembly Actin-myosin Filament Sliding Muscle Filament Sliding Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Actin-mediated Cell Contraction Regulation Of Cytoskeleton Organization Actin Filament Organization Actin Filament-based Movement Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Pointed-end Actin Filament Capping Regulation Of Chromosome Segregation Regulation Of Actin Polymerization Or Depolymerization Myofibril Assembly Regulation Of Actin Filament Length Cell-cell Junction Organization Regulation Of Mitotic Cell Cycle Muscle Contraction Cell Division Cell Cycle Muscle System Process Organelle Assembly Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Cell Development Movement Of Cell Or Subcellular Component Mitotic Nuclear Division Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Regulation Of Muscle Contraction Positive Regulation Of Transcription Factor Import Into Nucleus Striated Muscle Cell Development Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Transforming Growth Factor Beta3 Production Inhibition Of APC-Cdc20 Complex Activity Regulation Of Metaphase Plate Congression Posterior Compartment Specification Anterior Compartment Pattern Formation Negative Regulation Of Cytoskeleton Organization Regulation Of Mitotic Sister Chromatid Separation Arp2/3 Complex-mediated Actin Nucleation Muscle Cell Development Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling	Response To Abiotic Stimulus Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Activation Of Adenylate Cyclase Activity Neurotrophin TRK Receptor Signaling Pathway Muscle Contraction Actin-myosin Filament Sliding Muscle Filament Sliding Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Transporter Activity Muscle System Process Fc Receptor Signaling Pathway Actin-mediated Cell Contraction Positive Regulation Of Lyase Activity Negative Regulation Of Ion Transmembrane Transport Innate Immune Response Activation Of Phospholipase C Activity Regulation Of Adenylate Cyclase Activity Negative Regulation Of Transmembrane Transport Positive Regulation Of Phospholipase C Activity Regulation Of Cytokinesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Actin Filament-based Movement Response To External Stimulus Regulation Of Cyclase Activity Regulation Of Sodium Ion Transport Positive Regulation Of CAMP Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Positive Regulation Of Cellular Glucuronidation Blood Coagulation Positive Regulation Of Cyclic Nucleotide Metabolic Process Hemostasis Regulation Of Phospholipase Activity Regulation Of CAMP Biosynthetic Process Positive Regulation Of Lipase Activity Immune Response-regulating Signaling Pathway Negative Regulation Of Ion Transport Regulation Of CAMP Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Skeletal Muscle Fiber Adaptation TRAM-dependent Toll-like Receptor 4 Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin
Tagcloud ?		aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next ntrk1 oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput transforming trk trka trkb trkc	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier col1a1 custom ezr fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Difference) ?		aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next ntrk1 oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput transforming trk trka trkb trkc	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier col1a1 custom ezr fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Intersection) ?