TPM3 and FAM9C

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		TPM3	FAM9C
Description		tropomyosin 3	family with sequence similarity 9 member C
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Mitochondrion Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Extracellular Exosome	Synaptonemal Complex Nucleus
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Protein Binding
	Biological Process	Muscle Contraction Actin Filament Organization	Spermatid Development Meiotic Cell Cycle
Pathways		Striated Muscle Contraction Smooth Muscle Contraction RHOV GTPase cycle Signaling by ALK fusions and activated point mutants
Drugs		Phenethyl Isothiocyanate
Diseases		Congenital fiber type disproportion (CFTD) Cap myopathy Thyroid cancer Nemaline myopathy
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Platelet count ( 27863252) Smoking initiation (ever regular vs never regular) ( 30679032) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Asthma ( 30929738) Asthma (childhood onset) ( 30929738)
Interacting Genes		60 interacting genes: ACTA1 ACTB BLOC1S6 C1orf216 CAVIN3 CCDC102B CCDC146 CCHCR1 CHRM3 CNN1 DVL2 FAM9C FBXO5 FGA FNDC3B HDDC3 HOOK2 HSF2 HSF4 IFIT3 IKBIP ISG15 KCNE1 KIFC3 KXD1 LCA5L LURAP1 MAD1L1 MAGEA11 MAST2 NEK2 NOD2 NUP54 ODAD1 OIP5 PBX3 PHLDB3 S100A2 S100A4 SMAD3 SNAPIN SUMO4 SYCE1 TAB2 TFPT THAP1 THAP7 TLK1 TMOD1 TMOD2 TNNI1 TNNT1 TRAP1 TRIM27 TRIP6 TSKS VPS52 WASH3P WASHC1 XIAP	8 interacting genes: ABI2 BORCS6 CFTR SKA1 SNAPC5 TEX12 TPM3 TRIML2
Entrez ID		7170	171484
HPRD ID		01840	06507
Ensembl ID		ENSG00000143549	ENSG00000187268
Uniprot IDs		A0A087WWU8 A0A0S2Z4G4 A0A0S2Z4G8 A0A0S2Z4I4 A0A2R2Y2Q3 B4DQ80 J3KN67 P06753	Q8IZT9
PDB IDs		6OTN
Enriched GO Terms of Interacting Partners?		Cytoskeleton Striated Muscle Thin Filament Actin Filament Organization Supramolecular Fiber Organization Tropomyosin Binding Identical Protein Binding BLOC-1 Complex Centriole Arp2/3 Complex-mediated Actin Nucleation Actin Binding Muscle Contraction P38MAPK Cascade Actin Nucleation Protein K63-linked Ubiquitination Pointed-end Actin Filament Capping Regulation Of Actin Cytoskeleton Organization Muscle System Process Organelle Organization Protein Linear Polyubiquitination Phosphatidylinositol 3-kinase Inhibitor Activity Regulation Of Actin Nucleation Transition Between Fast And Slow Fiber Regulation Of Actin Filament Organization Troponin Complex Regulation Of Lysosome Size BORC Complex Regulation Of Actin Filament-based Process Microtubule-based Movement Microtubule-based Process Retrograde Transport, Endosome To Golgi Microvesicle Actin Filament-based Process Cytoskeleton Organization Regulation Of Protein Ubiquitination Actomyosin Structure Organization Regulation Of Skeletal Muscle Adaptation Regulation Of Endosome Size Cytoskeleton-dependent Intracellular Transport Regulation Of Organelle Organization Regulation Of System Process Positive Regulation Of Biomineral Tissue Development Intracellular Transport Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Vesicle Organization Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Side Of Lysosomal Membrane Lysosomal Transport Protein Kinase Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction	Bicarbonate Transmembrane Transporter Activity Organelle Localization Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Membrane Hyperpolarization Actin Filament Muscle Thin Filament Tropomyosin Positive Regulation Of Supramolecular Fiber Organization Actin-based Cell Projection Lens Fiber Cell Morphogenesis Zonula Adherens Assembly Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Transcription Initiation At RNA Polymerase III Promoter SnRNA Transcription By RNA Polymerase III Regulation Of Lysosome Size BORC Complex Meiotic DNA Repair Synthesis Central Element Establishment Of Meiotic Spindle Orientation Establishment Of Meiotic Spindle Localization SKA Complex Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling
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