TPM3 and TMOD1

Number of citations of the paper that reports this interaction (PubMedID 34079125)
0

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vitro)

		TPM3	TMOD1
Description		tropomyosin 3	tropomodulin 1
Image
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Mitochondrion Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament COP9 Signalosome Membrane Myofibril Sarcomere Cortical Cytoskeleton
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Actin Binding Tropomyosin Binding
	Biological Process	Muscle Contraction Actin Filament Organization	Muscle Contraction Actin Filament Organization Adult Locomotory Behavior Myofibril Assembly Pointed-end Actin Filament Capping Lens Fiber Cell Development
Pathways		Striated Muscle Contraction Smooth Muscle Contraction RHOV GTPase cycle Signaling by ALK fusions and activated point mutants	Striated Muscle Contraction
Drugs		Phenethyl Isothiocyanate
Diseases		Congenital fiber type disproportion (CFTD) Cap myopathy Thyroid cancer Nemaline myopathy
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Platelet count ( 27863252) Smoking initiation (ever regular vs never regular) ( 30679032) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Intracranial aneurysm ( 30823506) Obesity-related traits ( 23251661) Thyroid cancer (Papillary, radiation-related) ( 20350937) Zinc levels ( 26025379)
Interacting Genes		60 interacting genes: ACTA1 ACTB BLOC1S6 C1orf216 CAVIN3 CCDC102B CCDC146 CCHCR1 CHRM3 CNN1 DVL2 FAM9C FBXO5 FGA FNDC3B HDDC3 HOOK2 HSF2 HSF4 IFIT3 IKBIP ISG15 KCNE1 KIFC3 KXD1 LCA5L LURAP1 MAD1L1 MAGEA11 MAST2 NEK2 NOD2 NUP54 ODAD1 OIP5 PBX3 PHLDB3 S100A2 S100A4 SMAD3 SNAPIN SUMO4 SYCE1 TAB2 TFPT THAP1 THAP7 TLK1 TMOD1 TMOD2 TNNI1 TNNT1 TRAP1 TRIM27 TRIP6 TSKS VPS52 WASH3P WASHC1 XIAP	16 interacting genes: APC BUB1 CDH1 CDKN2A DCC DLC1 FBXL17 FBXW7 MLH3 NEB ODC1 PIK3CA PRKAA2 TLR2 TMSB10 TPM3
Entrez ID		7170	7111
HPRD ID		01840	01838
Ensembl ID		ENSG00000143549	ENSG00000136842
Uniprot IDs		A0A087WWU8 A0A0S2Z4G4 A0A0S2Z4G8 A0A0S2Z4I4 A0A2R2Y2Q3 B4DQ80 J3KN67 P06753	P28289
PDB IDs		6OTN	4PKG 4PKH 4PKI 4Z8G 4Z94 8F8T
Enriched GO Terms of Interacting Partners?		Cytoskeleton Striated Muscle Thin Filament Actin Filament Organization Supramolecular Fiber Organization Tropomyosin Binding Identical Protein Binding BLOC-1 Complex Centriole Arp2/3 Complex-mediated Actin Nucleation Actin Binding Muscle Contraction P38MAPK Cascade Actin Nucleation Protein K63-linked Ubiquitination Pointed-end Actin Filament Capping Regulation Of Actin Cytoskeleton Organization Muscle System Process Organelle Organization Protein Linear Polyubiquitination Phosphatidylinositol 3-kinase Inhibitor Activity Regulation Of Actin Nucleation Transition Between Fast And Slow Fiber Regulation Of Actin Filament Organization Troponin Complex Regulation Of Lysosome Size BORC Complex Regulation Of Actin Filament-based Process Microtubule-based Movement Microtubule-based Process Retrograde Transport, Endosome To Golgi Microvesicle Actin Filament-based Process Cytoskeleton Organization Regulation Of Protein Ubiquitination Actomyosin Structure Organization Regulation Of Skeletal Muscle Adaptation Regulation Of Endosome Size Cytoskeleton-dependent Intracellular Transport Regulation Of Organelle Organization Regulation Of System Process Positive Regulation Of Biomineral Tissue Development Intracellular Transport Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Vesicle Organization Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Side Of Lysosomal Membrane Lysosomal Transport Protein Kinase Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction	Negative Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Regulation Of Protein Localization Regulation Of Cellular Component Organization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Gamma-catenin Binding Regulation Of Cytoskeleton Organization Apoptotic Process Negative Regulation Of Cell Development Cell Death Programmed Cell Death Negative Regulation Of Cytoskeleton Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Cell Communication Negative Regulation Of Supramolecular Fiber Organization Catenin Complex Regulation Of Protein Catabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Signaling Cytosol Postsynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Nervous System Development Regulation Of Organelle Organization Negative Regulation Of Cell Growth Negative Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell-matrix Adhesion Lamellipodium Sister Chromatid Cohesion Regulation Of Macroautophagy Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Cellular Response To Oxygen-containing Compound Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Protein Targeting To Mitochondrion Ligase Inhibitor Activity Supramolecular Fiber Organization Triacyl Lipopeptide Binding Regulation Of Mitotic Cell Cycle Negative Regulation Of Growth Negative Regulation Of Axonogenesis Regulation Of Apoptotic Process Cytoplasm Positive Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization
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