TFPT and EAF2

Number of citations of the paper that reports this interaction (PMID 17395368)
1

Data Source:
HPRD (two hybrid, in vivo)

		TFPT	EAF2
Gene Name		TCF3 (E2A) fusion partner (in childhood Leukemia)	ELL associated factor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Actin Filament Ino80 Complex Nuclear Membrane	Transcription Elongation Factor Complex Nuclear Speck ELL-EAF Complex
	Molecular Function	DNA Binding Protein Binding Protein Kinase Binding Protein Heterodimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding
	Biological Process	DNA Repair DNA Recombination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Apoptotic Process Apoptotic Signaling Pathway	Transcription, DNA-templated Apoptotic Process Negative Regulation Of Cell Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		23 interactors: APP C4orf46 CCDC67 CDCA7L DYDC1 EAF1 EAF2 ELL HAUS1 KRT19 LMO2 NOL3 PAWR PIM1 RALBP1 RPGRIP1 RUNDC3A SDCCAG3 STK3 TCF3 TFIP11 TPM1 TPM3	7 interactors: BEND7 BIRC2 ELL TCEA1 TCEA2 TFPT TRIM23
Entrez ID		29844	55840
HPRD ID		10266	09634
Ensembl ID		ENSG00000105619	ENSG00000145088
Uniprot IDs		P0C1Z6	B4DWJ3 Q96CJ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Apoptotic Process RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Programmed Cell Death Regulation Of Metabolic Process Cell Death Death Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Embryo Development Regulation Of Transcription, DNA-templated Actin-myosin Filament Sliding Muscle Filament Sliding Regulation Of Nucleic Acid-templated Transcription Embryonic Hemopoiesis Regulation Of RNA Biosynthetic Process Cell Differentiation Involved In Embryonic Placenta Development Regulation Of RNA Metabolic Process Regulation Of Catalytic Activity Organelle Assembly Actin-mediated Cell Contraction Cellular Component Assembly In Utero Embryonic Development Spliceosomal Complex Disassembly Response To Injury Involved In Regulation Of Muscle Adaptation Positive Regulation Of Heart Rate By Epinephrine Sarcomere Organization Regulation Of B Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Actin Filament-based Movement Positive Regulation Of Catalytic Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Cell Cycle Actin Filament-based Process Myofibril Assembly Transcription, DNA-templated Organ Development Muscle Cell Differentiation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Collateral Sprouting In Absence Of Injury Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Tissue Development Protein Stabilization Developmental Process	Regulation Of DNA-templated Transcription, Elongation DNA-templated Transcription, Elongation Transcription, DNA-templated Positive Regulation Of Viral Transcription RNA Biosynthetic Process Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process Viral Process RNA Metabolic Process Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Regulation Of Viral Process Translational Elongation Regulation Of Protein Monoubiquitination Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process SnRNA Transcription From RNA Polymerase III Promoter Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter SnRNA Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Nitrogen Compound Metabolic Process SnRNA Transcription Positive Regulation Of Transcription From RNA Polymerase III Promoter Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Necroptotic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Necrotic Cell Death Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Negative Regulation Of Hydrolase Activity Positive Regulation Of Macromolecule Biosynthetic Process
Tagcloud ?			aberrant aim2 bh3 bik complements constitutive cooperates diffuse dlbcl expansion forkhead foxp1 harakiri lymphoid lymphoma lymphomagenesis lymphomas mucosa next oncogene proapoptotic promote rassf6 regarded relying represses repression tp53inp1 tp63
Tagcloud (Difference) ?			aberrant aim2 bh3 bik complements constitutive cooperates diffuse dlbcl expansion forkhead foxp1 harakiri lymphoid lymphoma lymphomagenesis lymphomas mucosa next oncogene proapoptotic promote rassf6 regarded relying represses repression tp53inp1 tp63
Tagcloud (Intersection) ?