TPM3 and THAP7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TPM3	THAP7
Description		tropomyosin 3	THAP domain containing 7
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Mitochondrion Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Extracellular Exosome	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Speck Nuclear Membrane
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Transcription Corepressor Binding DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding C2H2 Zinc Finger Domain Binding Histone H4 Reader Activity General Transcription Initiation Factor Binding Histone Reader Activity
	Biological Process	Muscle Contraction Actin Filament Organization	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription
Pathways		Striated Muscle Contraction Smooth Muscle Contraction RHOV GTPase cycle Signaling by ALK fusions and activated point mutants
Drugs		Phenethyl Isothiocyanate
Diseases		Congenital fiber type disproportion (CFTD) Cap myopathy Thyroid cancer Nemaline myopathy
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Platelet count ( 27863252) Smoking initiation (ever regular vs never regular) ( 30679032) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		60 interacting genes: ACTA1 ACTB BLOC1S6 C1orf216 CAVIN3 CCDC102B CCDC146 CCHCR1 CHRM3 CNN1 DVL2 FAM9C FBXO5 FGA FNDC3B HDDC3 HOOK2 HSF2 HSF4 IFIT3 IKBIP ISG15 KCNE1 KIFC3 KXD1 LCA5L LURAP1 MAD1L1 MAGEA11 MAST2 NEK2 NOD2 NUP54 ODAD1 OIP5 PBX3 PHLDB3 S100A2 S100A4 SMAD3 SNAPIN SUMO4 SYCE1 TAB2 TFPT THAP1 THAP7 TLK1 TMOD1 TMOD2 TNNI1 TNNT1 TRAP1 TRIM27 TRIP6 TSKS VPS52 WASH3P WASHC1 XIAP	63 interacting genes: ANKRD28 APP CCDC136 CCDC85B CCNDBP1 CDC37 CYSRT1 DESI2 DVL3 EFEMP2 EHMT2 FBXO7 FHL3 FSD2 GABARAPL1 GNAI1 GOLGA2 GOLGA6L9 H3C1 H4C1 HCFC1 HDAC3 HOXA1 KRT27 KRT31 KRT34 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP17-1 KRTAP4-12 LDOC1 LNX1 LURAP1 LZTS2 MAGOHB MAP1LC3B MCC MDFI MID2 MTUS2 NBPF19 NOTCH2NLA NTAQ1 PELI2 PHC2 PHF19 PICK1 PIN1 PNMA2 PPP3CC SET TAF1B TFIP11 THAP11 TLE5 TPM3 TRAF1 TRAF2 TRAF5 ZDHHC17 ZRANB1
Entrez ID		7170	80764
HPRD ID		01840	15500
Ensembl ID		ENSG00000143549	ENSG00000184436
Uniprot IDs		A0A087WWU8 A0A0S2Z4G4 A0A0S2Z4G8 A0A0S2Z4I4 A0A2R2Y2Q3 B4DQ80 J3KN67 P06753	Q9BT49
PDB IDs		6OTN
Enriched GO Terms of Interacting Partners?		Cytoskeleton Striated Muscle Thin Filament Actin Filament Organization Supramolecular Fiber Organization Tropomyosin Binding Identical Protein Binding BLOC-1 Complex Centriole Arp2/3 Complex-mediated Actin Nucleation Actin Binding Muscle Contraction P38MAPK Cascade Actin Nucleation Protein K63-linked Ubiquitination Pointed-end Actin Filament Capping Regulation Of Actin Cytoskeleton Organization Muscle System Process Organelle Organization Protein Linear Polyubiquitination Phosphatidylinositol 3-kinase Inhibitor Activity Regulation Of Actin Nucleation Transition Between Fast And Slow Fiber Regulation Of Actin Filament Organization Troponin Complex Regulation Of Lysosome Size BORC Complex Regulation Of Actin Filament-based Process Microtubule-based Movement Microtubule-based Process Retrograde Transport, Endosome To Golgi Microvesicle Actin Filament-based Process Cytoskeleton Organization Regulation Of Protein Ubiquitination Actomyosin Structure Organization Regulation Of Skeletal Muscle Adaptation Regulation Of Endosome Size Cytoskeleton-dependent Intracellular Transport Regulation Of Organelle Organization Regulation Of System Process Positive Regulation Of Biomineral Tissue Development Intracellular Transport Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Vesicle Organization Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Side Of Lysosomal Membrane Lysosomal Transport Protein Kinase Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction	Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Thioesterase Binding Protein Binding Regulation Of Wnt Signaling Pathway Regulation Of JNK Cascade Regulation Of Toll Signaling Pathway Cytosol Intermediate Filament Organization Protein-containing Complex Disassembly Tumor Necrosis Factor Receptor Binding Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Wnt Signaling Pathway Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Protein Serine/threonine Phosphatase Complex CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cellular Response To Nitrogen Starvation Cytoskeleton CD40 Receptor Complex
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