PPP1CA and VDR

Number of citations of the paper that reports this interaction (PubMedID 12036952)
0

Data Source:
HPRD (in vivo)

		PPP1CA	VDR
Description		protein phosphatase 1 catalytic subunit alpha	vitamin D receptor
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Adherens Junction Glycogen Granule Neuronal Cell Body Dendritic Spine Perikaryon Extracellular Exosome PTW/PP1 Phosphatase Complex Presynapse Postsynapse Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Iron Ion Binding Protein Binding Protein Phosphatase 1 Binding Hydrolase Activity Phosphatase Activity Ribonucleoprotein Complex Binding Protein-containing Complex Binding Metal Ion Binding Transition Metal Ion Binding Cadherin Binding Involved In Cell-cell Adhesion RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Vitamin D Binding Protein Binding Zinc Ion Binding Bile Acid Nuclear Receptor Activity Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Vitamin D Response Element Binding Calcitriol Binding Lithocholic Acid Binding
	Biological Process	Telomere Maintenance RNA Polymerase II Promoter Clearance Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Protein Dephosphorylation Response To Lead Ion Dephosphorylation Lung Development Circadian Regulation Of Gene Expression Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Telomere Maintenance In Response To DNA Damage Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Glycogen Biosynthetic Process Branching Morphogenesis Of An Epithelial Tube Protein Stabilization Cell Division Regulation Of Canonical Wnt Signaling Pathway Double-strand Break Repair Via Alternative Nonhomologous End Joining Cell-cell Adhesion Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Skeletal System Development Regulation Of DNA-templated Transcription Calcium Ion Transport Intracellular Calcium Ion Homeostasis Lactation Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Cell Differentiation Positive Regulation Of Bone Mineralization Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Phosphate Ion Transmembrane Transport Nuclear Receptor-mediated Bile Acid Signaling Pathway MRNA Transcription By RNA Polymerase II Cell-cell Junction Maintenance Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Decidualization Retinoic Acid Receptor Signaling Pathway Intestinal Absorption Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Response To Bile Acid Negative Regulation Of Phosphate Transmembrane Transport
Pathways		Triglyceride catabolism DARPP-32 events Downregulation of TGF-beta receptor signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	Vitamin D (calciferol) metabolism Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid	Calcitriol Calcifediol Ergocalciferol Cholecalciferol Paricalcitol Dihydrotachysterol Alfacalcidol Calcipotriol Lexacalcitol Seocalcitol Cholesterol Inecalcitol Becocalcidiol CTA018 Eldecalcitol Elocalcitol Doxercalciferol (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) Vitamin D Curcumin Curcumin sulfate
Diseases			Tuberculosis Localized autosomal recessive hypotrichosis
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 28552196)	Asthma (adult onset) ( 31036433) Basal cell carcinoma ( 33549134) Eosinophil percentage of white cells ( 32888494) Gout ( 22179738) Gut microbiota (beta diversity) ( 27723756) Inflammatory bowel disease ( 23128233) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Menarche (age at onset) ( 25231870) Serum immune biomarker levels ( 32066700)
Interacting Genes		173 interacting genes: AATK AHCTF1 AKAP1 AKAP11 AKAP9 AKT1 APAF1 ASPM AURKA BAD BAX BCL2 BCL2L1 BCL2L2 BRCA1 BTBD10 C1QA CAD CAV1 CCDC181 CDC5L CDCA2 CDH1 CEP126 CEP170 CEP192 CKB CLCN2 CLOCK CNP CNST CNTN1 CREB1 CRK CSNK1E CSNK2B CSRNP1 CSRNP2 CUL1 CXXC1 DCTN1 DCX DEAF1 DELEC1 DYNLT4 EED EIF2AK2 ESR1 FRMPD4 FXYD1 GLIPR1L2 GPKOW H2AX H3-3A H3C1 HEYL HSPA4 IBTK ID2 ITGB8 JPH3 KANK1 KCNQ1 KCTD20 KIF13A KIF18A KNL1 LMTK2 LPIN2 MAFG MAL2 MAP4K4 MAPK1 MAPK3 MAPT MECOM MIIP MKI67 MPHOSPH10 MST1R MYO16 NCAM1 NDP NEDD8 NEK2 NOC2L NOM1 NONO NOP53 PAK1 PBK PCDH7 PCNA PHACTR1 PHACTR3 PHACTR4 PHB2 PHC1 PIAS1 PIAS3 PLCL2 POLR2A PPP1R10 PPP1R11 PPP1R13B PPP1R13L PPP1R15A PPP1R15B PPP1R16A PPP1R18 PPP1R1B PPP1R2 PPP1R26 PPP1R27 PPP1R2B PPP1R2C PPP1R37 PPP1R3B PPP1R3C PPP1R3D PPP1R3E PPP1R3G PPP1R8 PPP1R9A PPP1R9B PPP2CA PPP2R5C PPP2R5E PREX1 PRKCB PRKCD PRR16 PTEN PTPN7 PYGM RANBP9 RB1 RORC RPRD2 RRP1B SAXO4 SEH1L SFI1 SFRP1 SH3RF2 SKP1 SLC45A1 SORL1 SPRED1 STAM STAU1 SYTL2 TOE1 TOR1AIP1 TOX4 TP53 TP53BP2 TPRN TRIM21 TSC2 TUSC3 UBC UBE2Z UBR5 ULK1 VDR WBP11 WDR82 YLPM1 ZBTB11 ZFYVE16 ZFYVE9 ZNF827	79 interacting genes: ACTN4 ACVR1 ANKRD11 BAG1 CCND3 CDCA7L CDK7 CFH CLASRP COPS2 CREBBP CSNK2A1 CXXC5 FGR FOS FOXO3 GABARAPL1 GABARAPL2 GNPAT GOLM2 GRIP1 GTF2B HMGN3 HR JUN KDM5A LCOR MAPK1 MAPK3 MED1 MED14 MED23 MEOX2 MMRN2 MYC NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NKD2 NR0B2 NR1H2 NRIP1 NSD1 NTAQ1 OTUD4 POLR2A POU1F1 POU2F1 PPARG PPP1CA PPP2CA PRCP PRKCSH PRKN PSMC5 RB1 RNF14 RPS6KC1 RUNX1 RUNX1T1 RXRA RXRB RXRG SIRT1 SMAD3 SNW1 SRC SRPK1 STAT1 TAF11 TDG TRIM24 TRIP13 UBR5 ZBTB16
Entrez ID		5499	7421
HPRD ID		15942	03463
Ensembl ID		ENSG00000172531	ENSG00000111424
Uniprot IDs		A0A140VJS9 P62136	A0A5K1VW50 F1D8P8 P11473
PDB IDs		3E7A 3E7B 3EGG 3EGH 3HVQ 3N5U 3V4Y 4G9J 4MOV 4MOY 4MP0 4XPN 5IOH 6ALZ 6CZO 6DCX 6DNO 6G0I 6G0J 6GHM 6OBN 6OBP 6OBQ 6OBR 6OBS 6OBU 6ZEE 6ZEF 6ZEG 6ZEH 6ZEI 6ZEJ 6ZK6 7QFB 7QM2 7T0Y 7TVF 7TXH 7UPI 8DWK 8DWL 8SW5 8SW6 8U5G	1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 3AZ2 3AZ3 3B0T 3CS4 3CS6 3KPZ 3M7R 3OGT 3P8X 3TKC 3VHW 3W0A 3W0C 3W0Y 3WGP 3WWR 3X31 3X36 4G2I 4ITE 4ITF 5GT4 5V39 5YSY 5YT2 7QPP 8IQN 8IQT
Enriched GO Terms of Interacting Partners?		Protein Phosphatase 1 Binding Protein Phosphatase Inhibitor Activity Phosphatase Binding Intracellular Signal Transduction Protein Phosphatase Regulator Activity Protein Phosphatase Type 1 Complex Negative Regulation Of Intracellular Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Regulation Of Cell Cycle Enzyme Binding Regulation Of Intracellular Signal Transduction Nucleoplasm Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway Nucleus Glycogen Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Glycogen Binding Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Cytoplasm Positive Regulation Of Metabolic Process Polysaccharide Metabolic Process Energy Reserve Metabolic Process Cell Population Proliferation Release Of Cytochrome C From Mitochondria Chromosome Response To Radiation Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Programmed Cell Death Response To Starvation Regulation Of Glycogen Biosynthetic Process Protein Localization To Organelle Negative Regulation Of Apoptotic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Metabolic Process Signal Transduction Cellular Response To Oxygen-containing Compound Response To Light Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Bcl-2 Family Protein Complex	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Nuclear Receptor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Retinoic Acid Receptor Signaling Pathway Nuclear Retinoic Acid Receptor Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding Hormone-mediated Signaling Pathway Transcription Coactivator Activity Transcription Corepressor Activity Nucleobase-containing Compound Biosynthetic Process DNA-binding Transcription Factor Binding Intracellular Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Metabolic Process Regulation Of MiRNA Transcription Peroxisome Proliferator Activated Receptor Signaling Pathway MRNA Transcription
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