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PPP1CA and CRK
Number of citations of the paper that reports this interaction (PubMedID
22321011
)
74
Data Source:
BioGRID
(two hybrid)
PPP1CA
CRK
Description
protein phosphatase 1 catalytic subunit alpha
CRK proto-oncogene, adaptor protein
Image
GO Annotations
Cellular Component
Protein Phosphatase Type 1 Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Adherens Junction
Glycogen Granule
Neuronal Cell Body
Dendritic Spine
Perikaryon
Extracellular Exosome
PTW/PP1 Phosphatase Complex
Presynapse
Postsynapse
Glutamatergic Synapse
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Actin Cytoskeleton
Membrane
Neuromuscular Junction
Protein-containing Complex
Extracellular Exosome
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Iron Ion Binding
Protein Binding
Protein Phosphatase 1 Binding
Hydrolase Activity
Phosphatase Activity
Ribonucleoprotein Complex Binding
Protein-containing Complex Binding
Metal Ion Binding
Transition Metal Ion Binding
Cadherin Binding Involved In Cell-cell Adhesion
RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity
Phosphotyrosine Residue Binding
Signaling Receptor Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Cytoskeletal Protein Binding
SH3 Domain Binding
Enzyme Binding
Kinase Binding
Protein Domain Specific Binding
Signaling Receptor Complex Adaptor Activity
Protein-macromolecule Adaptor Activity
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
SH2 Domain Binding
Protein Phosphorylated Amino Acid Binding
Ephrin Receptor Binding
Scaffold Protein Binding
Protein Tyrosine Kinase Binding
Biological Process
Telomere Maintenance
RNA Polymerase II Promoter Clearance
Glycogen Metabolic Process
Regulation Of Glycogen Biosynthetic Process
Regulation Of Glycogen Catabolic Process
Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Protein Dephosphorylation
Response To Lead Ion
Dephosphorylation
Lung Development
Circadian Regulation Of Gene Expression
Positive Regulation Of Transcription Elongation By RNA Polymerase II
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Telomere Maintenance In Response To DNA Damage
Regulation Of Translational Initiation In Response To Stress
Positive Regulation Of Glycogen Biosynthetic Process
Branching Morphogenesis Of An Epithelial Tube
Protein Stabilization
Cell Division
Regulation Of Canonical Wnt Signaling Pathway
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Cell-cell Adhesion
Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Neuron Migration
Response To Yeast
Regulation Of Leukocyte Migration
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
Cell Population Proliferation
Regulation Of Cell Shape
Regulation Of Signal Transduction
Positive Regulation Of Smooth Muscle Cell Migration
Dendrite Development
Cell Migration
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Actin Cytoskeleton Organization
Positive Regulation Of Cell Growth
Regulation Of Actin Cytoskeleton Organization
Regulation Of Cell Adhesion Mediated By Integrin
Regulation Of Rac Protein Signal Transduction
Positive Regulation Of Rac Protein Signal Transduction
Helper T Cell Diapedesis
Response To Hepatocyte Growth Factor
Reelin-mediated Signaling Pathway
Response To Hydrogen Peroxide
Regulation Of GTPase Activity
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of JNK Cascade
Ephrin Receptor Signaling Pathway
Regulation Of Dendrite Development
Cell Chemotaxis
Regulation Of Wound Healing
Negative Regulation Of Wound Healing
Response To Cholecystokinin
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To Nitric Oxide
Protein Localization To Membrane
Postsynaptic Specialization Assembly
Cerebellar Neuron Development
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Response To Peptide
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Cellular Response To Endothelin
Regulation Of Cell Motility
Negative Regulation Of Cell Motility
Regulation Of T Cell Migration
Pathways
Triglyceride catabolism
DARPP-32 events
Downregulation of TGF-beta receptor signaling
Maturation of hRSV A proteins
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
ARMS-mediated activation
ARMS-mediated activation
Downstream signal transduction
Regulation of actin dynamics for phagocytic cup formation
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAP1 and RAC1
MET receptor recycling
Regulation of signaling by CBL
FCGR3A-mediated phagocytosis
Drugs
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
Diseases
GWAS
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Height (
28552196
)
Atrial fibrillation (
30061737
)
Granulocyte count (
27863252
)
Intraocular pressure (
30591961
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Myeloid white cell count (
27863252
)
Neutrophil count (
27863252
)
Pulse pressure (
27841878
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systolic blood pressure (
27841878
28135244
30578418
)
Interacting Genes
173 interacting genes:
AATK
AHCTF1
AKAP1
AKAP11
AKAP9
AKT1
APAF1
ASPM
AURKA
BAD
BAX
BCL2
BCL2L1
BCL2L2
BRCA1
BTBD10
C1QA
CAD
CAV1
CCDC181
CDC5L
CDCA2
CDH1
CEP126
CEP170
CEP192
CKB
CLCN2
CLOCK
CNP
CNST
CNTN1
CREB1
CRK
CSNK1E
CSNK2B
CSRNP1
CSRNP2
CUL1
CXXC1
DCTN1
DCX
DEAF1
DELEC1
DYNLT4
EED
EIF2AK2
ESR1
FRMPD4
FXYD1
GLIPR1L2
GPKOW
H2AX
H3-3A
H3C1
HEYL
HSPA4
IBTK
ID2
ITGB8
JPH3
KANK1
KCNQ1
KCTD20
KIF13A
KIF18A
KNL1
LMTK2
LPIN2
MAFG
MAL2
MAP4K4
MAPK1
MAPK3
MAPT
MECOM
MIIP
MKI67
MPHOSPH10
MST1R
MYO16
NCAM1
NDP
NEDD8
NEK2
NOC2L
NOM1
NONO
NOP53
PAK1
PBK
PCDH7
PCNA
PHACTR1
PHACTR3
PHACTR4
PHB2
PHC1
PIAS1
PIAS3
PLCL2
POLR2A
PPP1R10
PPP1R11
PPP1R13B
PPP1R13L
PPP1R15A
PPP1R15B
PPP1R16A
PPP1R18
PPP1R1B
PPP1R2
PPP1R26
PPP1R27
PPP1R2B
PPP1R2C
PPP1R37
PPP1R3B
PPP1R3C
PPP1R3D
PPP1R3E
PPP1R3G
PPP1R8
PPP1R9A
PPP1R9B
PPP2CA
PPP2R5C
PPP2R5E
PREX1
PRKCB
PRKCD
PRR16
PTEN
PTPN7
PYGM
RANBP9
RB1
RORC
RPRD2
RRP1B
SAXO4
SEH1L
SFI1
SFRP1
SH3RF2
SKP1
SLC45A1
SORL1
SPRED1
STAM
STAU1
SYTL2
TOE1
TOR1AIP1
TOX4
TP53
TP53BP2
TPRN
TRIM21
TSC2
TUSC3
UBC
UBE2Z
UBR5
ULK1
VDR
WBP11
WDR82
YLPM1
ZBTB11
ZFYVE16
ZFYVE9
ZNF827
189 interacting genes:
ABL1
ABL2
ADGRL3
ANKZF1
ANLN
AR
ARHGAP17
ARHGAP32
ASAP1
ASAP3
ASCL4
ATF3
ATXN1
AVIL
BATF3
BCAR1
BCR
BEX5
BICRA
BUB1
C1orf94
C4orf17
C6orf141
CBL
CBLC
CHTF18
CLNK
CNDP2
CORO6
CRKL
DAB1
DOCK1
DOCK3
DOCK5
DOK1
DOK2
DOK3
DOK4
DOK7
DPPA4
EFS
EGFR
ELK1
ELK3
EPHA3
EPHB2
EPHB3
EPHB6
EPS15
EPYC
ERBB2
ERBB3
ERBB4
ESD
EYA3
FAM110B
FASLG
FER
FGFR1
FLACC1
FLT1
FRS2
FSTL1
FYN
GAB1
GABPB2
GAREM1
GRB2
HABP4
HSH2D
IFT140
IGF1R
IKZF3
INO80E
INPP5D
INSR
IQCE
IRS1
IRS2
IRS4
ISL1
IVL
KCNJ3
KCTD13
KCTD17
KDR
KHDRBS1
KIT
KLF15
KLHL20
KMT2E
LASP1
LHX8
LNX2
MAGEC3
MAP4K1
MAP4K5
MAPK4
MAPK8
MET
MICAL1
MNDA
MPG
MYLIP
MYOZ2
NCK1
NEDD9
NPM3
NTRK1
NUFIP2
OFCC1
PAFAH1B2
PDGFRA
PDGFRB
PHC2
PIK3R1
PIK3R2
PIK3R3
PLSCR1
POT1
PPFIBP2
PPP1CA
PRKACA
PRR14
PRRC2B
PRRG2
PSMC1
PSMC6
PTK2
PTK2B
PTPN1
PTPN22
PTPN4
PTPRH
PTTG1
PXN
RAB2B
RAD54L2
RAPGEF1
REPS1
RET
RTCB
RYBP
SASH1
SAXO1
SEMA4D
SEPTIN6
SETD9
SH2B1
SH2D2A
SH3BP1
SHB
SHC1
SOCS1
SOCS6
SOS1
SPATA31F1
SPEN
SPRR2A
STAT4
STAT5A
STAT5B
STRN4
SYN1
SYNGAP1
TASOR2
TCAP
TCOF1
TDG
TERF2IP
TM4SF19
TP53BP2
TRIM25
TUBA1C
TWIST2
TXK
USP53
VAC14
VAV1
VPS37B
WASF1
WDR83
WEE1
XPO1
ZAP70
ZKSCAN5
ZKSCAN7
ZNF557
ZNF804A
Entrez ID
5499
1398
HPRD ID
15942
01267
Ensembl ID
ENSG00000172531
ENSG00000167193
Uniprot IDs
A0A140VJS9
P62136
A0A0S2Z3K9
A0A0S2Z3Q4
L7RT18
P46108
PDB IDs
3E7A
3E7B
3EGG
3EGH
3HVQ
3N5U
3V4Y
4G9J
4MOV
4MOY
4MP0
4XPN
5IOH
6ALZ
6CZO
6DCX
6DNO
6G0I
6G0J
6GHM
6OBN
6OBP
6OBQ
6OBR
6OBS
6OBU
6ZEE
6ZEF
6ZEG
6ZEH
6ZEI
6ZEJ
6ZK6
7QFB
7QM2
7T0Y
7TVF
7TXH
7UPI
8DWK
8DWL
8SW5
8SW6
8U5G
1JU5
2DVJ
2EYV
2EYW
2EYX
2EYY
2EYZ
2MS4
5UL6
6ATV
Enriched GO Terms of Interacting Partners
?
Protein Phosphatase 1 Binding
Protein Phosphatase Inhibitor Activity
Phosphatase Binding
Intracellular Signal Transduction
Protein Phosphatase Regulator Activity
Protein Phosphatase Type 1 Complex
Negative Regulation Of Intracellular Signal Transduction
Apoptotic Process
Programmed Cell Death
Cell Death
Regulation Of Cell Cycle
Enzyme Binding
Regulation Of Intracellular Signal Transduction
Nucleoplasm
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Intrinsic Apoptotic Signaling Pathway
Nucleus
Glycogen Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Glycogen Binding
Regulation Of Cell Cycle Process
Positive Regulation Of Macromolecule Metabolic Process
Cellular Response To Stress
Cytoplasm
Positive Regulation Of Metabolic Process
Polysaccharide Metabolic Process
Energy Reserve Metabolic Process
Cell Population Proliferation
Release Of Cytochrome C From Mitochondria
Chromosome
Response To Radiation
Apoptotic Signaling Pathway
Negative Regulation Of Metabolic Process
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Programmed Cell Death
Response To Starvation
Regulation Of Glycogen Biosynthetic Process
Protein Localization To Organelle
Negative Regulation Of Apoptotic Process
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Protein Metabolic Process
Signal Transduction
Cellular Response To Oxygen-containing Compound
Response To Light Stimulus
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Bcl-2 Family Protein Complex
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Activity
SH3 Domain Binding
Peptidyl-tyrosine Phosphorylation
Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Kinase Activity
Cell Migration
Phosphotyrosine Residue Binding
Regulation Of Intracellular Signal Transduction
Protein Binding
Cell Motility
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Kinase Activity
Insulin Receptor Signaling Pathway
Cytosol
Protein Phosphorylation
Response To Growth Factor
Positive Regulation Of Cellular Component Organization
Regulation Of MAPK Cascade
Positive Regulation Of Cell Migration
ERBB Signaling Pathway
Phosphorylation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Motility
Cytoplasm
Protein Autophosphorylation
Regulation Of Cellular Component Organization
Positive Regulation Of Signal Transduction
Positive Regulation Of Locomotion
Regulation Of Signaling
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Positive Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signaling Cassette
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Communication
Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Cell Migration
Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Cell Motility
Regulation Of Cell Adhesion
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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