PPP1CA and CAD

Number of citations of the paper that reports this interaction (PubMedID 4092695)
29

Data Source:
HPRD (in vitro)

		PPP1CA	CAD
Description		protein phosphatase 1 catalytic subunit alpha	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Adherens Junction Glycogen Granule Neuronal Cell Body Dendritic Spine Perikaryon Extracellular Exosome PTW/PP1 Phosphatase Complex Presynapse Postsynapse Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Membrane Nuclear Matrix Protein-containing Complex Cell Projection Neuronal Cell Body Terminal Bouton Extracellular Exosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Iron Ion Binding Protein Binding Protein Phosphatase 1 Binding Hydrolase Activity Phosphatase Activity Ribonucleoprotein Complex Binding Protein-containing Complex Binding Metal Ion Binding Transition Metal Ion Binding Cadherin Binding Involved In Cell-cell Adhesion RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity	Nucleotide Binding Catalytic Activity Aspartate Carbamoyltransferase Activity Carbamoyl-phosphate Synthase (ammonia) Activity Carbamoyl-phosphate Synthase (glutamine-hydrolyzing) Activity Dihydroorotase Activity Glutaminase Activity Protein Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Amino Acid Binding Transferase Activity Carboxyl- Or Carbamoyltransferase Activity Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Ligase Activity Enzyme Binding Identical Protein Binding Metal Ion Binding Aspartate Binding
	Biological Process	Telomere Maintenance RNA Polymerase II Promoter Clearance Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Protein Dephosphorylation Response To Lead Ion Dephosphorylation Lung Development Circadian Regulation Of Gene Expression Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Telomere Maintenance In Response To DNA Damage Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Glycogen Biosynthetic Process Branching Morphogenesis Of An Epithelial Tube Protein Stabilization Cell Division Regulation Of Canonical Wnt Signaling Pathway Double-strand Break Repair Via Alternative Nonhomologous End Joining Cell-cell Adhesion Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Liver Development 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process UDP Biosynthetic Process UTP Biosynthetic Process Amino Acid Metabolic Process Glutamine Metabolic Process Phosphate-containing Compound Metabolic Process Xenobiotic Metabolic Process Heart Development Female Pregnancy Lactation Response To Amine Citrulline Biosynthetic Process Response To Caffeine Animal Organ Regeneration Response To Insulin Response To Testosterone Response To Starvation 'de Novo' UMP Biosynthetic Process Response To Cortisol Nucleobase-containing Small Molecule Metabolic Process Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus Pyrimidine-containing Compound Biosynthetic Process
Pathways		Triglyceride catabolism DARPP-32 events Downregulation of TGF-beta receptor signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	Pyrimidine biosynthesis
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid	Sparfosic acid
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 28552196)	Triglyceride levels ( 32203549)
Interacting Genes		173 interacting genes: AATK AHCTF1 AKAP1 AKAP11 AKAP9 AKT1 APAF1 ASPM AURKA BAD BAX BCL2 BCL2L1 BCL2L2 BRCA1 BTBD10 C1QA CAD CAV1 CCDC181 CDC5L CDCA2 CDH1 CEP126 CEP170 CEP192 CKB CLCN2 CLOCK CNP CNST CNTN1 CREB1 CRK CSNK1E CSNK2B CSRNP1 CSRNP2 CUL1 CXXC1 DCTN1 DCX DEAF1 DELEC1 DYNLT4 EED EIF2AK2 ESR1 FRMPD4 FXYD1 GLIPR1L2 GPKOW H2AX H3-3A H3C1 HEYL HSPA4 IBTK ID2 ITGB8 JPH3 KANK1 KCNQ1 KCTD20 KIF13A KIF18A KNL1 LMTK2 LPIN2 MAFG MAL2 MAP4K4 MAPK1 MAPK3 MAPT MECOM MIIP MKI67 MPHOSPH10 MST1R MYO16 NCAM1 NDP NEDD8 NEK2 NOC2L NOM1 NONO NOP53 PAK1 PBK PCDH7 PCNA PHACTR1 PHACTR3 PHACTR4 PHB2 PHC1 PIAS1 PIAS3 PLCL2 POLR2A PPP1R10 PPP1R11 PPP1R13B PPP1R13L PPP1R15A PPP1R15B PPP1R16A PPP1R18 PPP1R1B PPP1R2 PPP1R26 PPP1R27 PPP1R2B PPP1R2C PPP1R37 PPP1R3B PPP1R3C PPP1R3D PPP1R3E PPP1R3G PPP1R8 PPP1R9A PPP1R9B PPP2CA PPP2R5C PPP2R5E PREX1 PRKCB PRKCD PRR16 PTEN PTPN7 PYGM RANBP9 RB1 RORC RPRD2 RRP1B SAXO4 SEH1L SFI1 SFRP1 SH3RF2 SKP1 SLC45A1 SORL1 SPRED1 STAM STAU1 SYTL2 TOE1 TOR1AIP1 TOX4 TP53 TP53BP2 TPRN TRIM21 TSC2 TUSC3 UBC UBE2Z UBR5 ULK1 VDR WBP11 WDR82 YLPM1 ZBTB11 ZFYVE16 ZFYVE9 ZNF827	13 interacting genes: CASP3 CEBPA HTRA2 MAPK1 NEDD4 PPP1CA PPP2CA PRKACA PTEN RAD9A SUMO2 XIAP YWHAG
Entrez ID		5499	790
HPRD ID		15942	06437
Ensembl ID		ENSG00000172531	ENSG00000084774
Uniprot IDs		A0A140VJS9 P62136	F8VPD4 P27708
PDB IDs		3E7A 3E7B 3EGG 3EGH 3HVQ 3N5U 3V4Y 4G9J 4MOV 4MOY 4MP0 4XPN 5IOH 6ALZ 6CZO 6DCX 6DNO 6G0I 6G0J 6GHM 6OBN 6OBP 6OBQ 6OBR 6OBS 6OBU 6ZEE 6ZEF 6ZEG 6ZEH 6ZEI 6ZEJ 6ZK6 7QFB 7QM2 7T0Y 7TVF 7TXH 7UPI 8DWK 8DWL 8SW5 8SW6 8U5G	4BY3 4C6B 4C6C 4C6D 4C6E 4C6F 4C6I 4C6J 4C6K 4C6L 4C6M 4C6N 4C6O 4C6P 4C6Q 5G1N 5G1O 5G1P 5YNZ 6HFD 6HFE 6HFF 6HFH 6HFI 6HFJ 6HFK 6HFL 6HFN 6HFP 6HFQ 6HFR 6HFS 6HFU 6HG1 8GVZ 8GW0 8PBE 8PBG 8PBH 8PBI 8PBJ 8PBK 8PBM 8PBN 8PBP 8PBQ 8PBR 8PBS 8PBT 8PBU 9FS1 9FS2 9FS3
Enriched GO Terms of Interacting Partners?		Protein Phosphatase 1 Binding Protein Phosphatase Inhibitor Activity Phosphatase Binding Intracellular Signal Transduction Protein Phosphatase Regulator Activity Protein Phosphatase Type 1 Complex Negative Regulation Of Intracellular Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Regulation Of Cell Cycle Enzyme Binding Regulation Of Intracellular Signal Transduction Nucleoplasm Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway Nucleus Glycogen Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Glycogen Binding Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Cytoplasm Positive Regulation Of Metabolic Process Polysaccharide Metabolic Process Energy Reserve Metabolic Process Cell Population Proliferation Release Of Cytochrome C From Mitochondria Chromosome Response To Radiation Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Programmed Cell Death Response To Starvation Regulation Of Glycogen Biosynthetic Process Protein Localization To Organelle Negative Regulation Of Apoptotic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Metabolic Process Signal Transduction Cellular Response To Oxygen-containing Compound Response To Light Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Bcl-2 Family Protein Complex	Cellular Response To Stress Intracellular Signal Transduction Regulation Of Protein Metabolic Process Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Stress Regulation Of Cell Cycle RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Signal Transduction DNA Damage Response Execution Phase Of Apoptosis Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Response To Metal Ion Negative Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Cell Cycle Macromolecule Catabolic Process Negative Regulation Of Phosphate Metabolic Process Regulation Of Protein Stability Positive Regulation Of Signal Transduction Regulation Of Macroautophagy Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Catabolic Process Nucleus Protein Domain Specific Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Protein Catabolic Process Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Positive Regulation Of Metabolic Process Learning Or Memory Glutamatergic Synapse Regulation Of Phosphorus Metabolic Process Vascular Endothelial Cell Response To Fluid Shear Stress Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Regulation Of Gene Expression Cognition Response To Lead Ion
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?