PPHLN1 and SNCAIP

Number of citations of the paper that reports this interaction (PubMedID 19730898)
0

Data Source:
BioGRID (two hybrid)

		PPHLN1	SNCAIP
Description		periphilin 1	synuclein alpha interacting protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Cytosol	Nucleoplasm Cytoplasm Cytosol Synaptic Vesicle Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Neuronal Cell Body
	Molecular Function	RNA Binding Protein Binding	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Keratinization Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Protein Localization To Heterochromatin Constitutive Heterochromatin Formation	Cell Death Dopamine Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Inclusion Body Assembly
Pathways		Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	Amyloid fiber formation
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Coronary artery disease ( 29212778) Diastolic blood pressure ( 30224653) Refractive error ( 32231278)	Chronic kidney disease (end stage renal disease vs. normal eGFR) in type 1 diabetes ( 31537649) Delirium ( 29631748) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Mood disorder and prion disease ( 25897833) Response to paclitaxel in ovarian cancer (Caspase 3/7 EC50) ( 27047539)
Interacting Genes		27 interacting genes: APP BCL2L1 CASP5 CCDC57 CDC37 CDK6 CLK1 FBXO7 FXR1 ITGB1BP2 MTUS2 NAGK OGT PAXIP1 PPL SEPTIN8 SHANK3 SNCAIP SQSTM1 SRPK2 TGM2 TOMM20 TOPBP1 TP53BP2 TSGA10 UFD1 VIM	19 interacting genes: AGXT C11orf58 GET4 GSK3B NUB1 NUDT21 PIN1 PINK1 PPHLN1 PRKN PTN RNF19A SEPTIN4 SH2D3C SIAH1 SIAH2 SNCA TLE5 UBB
Entrez ID		51535	9627
HPRD ID		10488	04804
Ensembl ID		ENSG00000134283	ENSG00000064692
Uniprot IDs		F8W6A0 Q8NEY8	B7Z616 B7Z995 Q6L981 Q6L983 Q9Y6H5
PDB IDs		6SWG	2KES
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Synaptic Potentiation Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cytoplasm Regulation Of Cell Cycle Regulation Of Neuron Apoptotic Process Intracellular Membraneless Organelle Cell Death Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Neuron Projection Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Cytosol Glial Cell Development Scaffold Protein Binding Autophagy Of Mitochondrion Regulation Of Defense Response Intracellular Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Programmed Cell Death Cytoskeleton Protein Targeting Apoptotic Process Cellular Response To Catecholamine Stimulus Astrocyte Development Presynapse Programmed Cell Death Response To Catecholamine Synapse Response To Muramyl Dipeptide Regulation Of Innate Immune Response Positive Regulation Of Mitophagy SH3 Domain Binding Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Modulation Of Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Synaptic Transmission Protein Binding Developmental Process Regulation Of Mitotic Cell Cycle Organelle Organization	Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Lewy Body Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Signaling Pathway Regulation Of Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Macromolecule Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Dopamine Transport Proteolysis Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Dopamine Secretion Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Stability Protein Ubiquitination Mitochondrial Outer Membrane Axon Regulation Of Protein Modification Process Mitochondrion To Lysosome Vesicle-mediated Transport Cellular Response To Hydrogen Sulfide Monoamine Transport Protein Modification By Small Protein Conjugation Regulation Of Canonical Wnt Signaling Pathway Regulation Of Neuron Apoptotic Process Response To Hydrogen Sulfide Regulation Of Apoptotic Process Proteasomal Protein Catabolic Process Regulation Of Programmed Cell Death Regulation Of Catecholamine Secretion Catabolic Process Negative Regulation Of Mitochondrial Fission Regulation Of Synaptic Vesicle Transport Regulation Of Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Tau Protein Binding Positive Regulation Of Protein Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Post-translational Protein Modification Regulation Of Wnt Signaling Pathway Protein Modification Process Cytosol Negative Regulation Of Wnt Signaling Pathway
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