PPHLN1 and PPL

Number of citations of the paper that reports this interaction (PubMedID 12853457)
0

Data Source:
HPRD (two hybrid)

		PPHLN1	PPL
Description		periphilin 1	periplakin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Cytosol	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome Anchoring Junction
	Molecular Function	RNA Binding Protein Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding
	Biological Process	Keratinization Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Protein Localization To Heterochromatin Constitutive Heterochromatin Formation	Response To Mechanical Stimulus Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization
Pathways		Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	Formation of the cornified envelope Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Coronary artery disease ( 29212778) Diastolic blood pressure ( 30224653) Refractive error ( 32231278)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Cancer ( 29299148) Diastolic blood pressure ( 27841878 28135244) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		27 interacting genes: APP BCL2L1 CASP5 CCDC57 CDC37 CDK6 CLK1 FBXO7 FXR1 ITGB1BP2 MTUS2 NAGK OGT PAXIP1 PPL SEPTIN8 SHANK3 SNCAIP SQSTM1 SRPK2 TGM2 TOMM20 TOPBP1 TP53BP2 TSGA10 UFD1 VIM	44 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 MRPL28 OPRM1 PBX4 PICK1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM WEE2-AS1 ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16
Entrez ID		51535	5493
HPRD ID		10488	04187
Ensembl ID		ENSG00000134283	ENSG00000118898
Uniprot IDs		F8W6A0 Q8NEY8	O60437
PDB IDs		6SWG	4Q28
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Synaptic Potentiation Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cytoplasm Regulation Of Cell Cycle Regulation Of Neuron Apoptotic Process Intracellular Membraneless Organelle Cell Death Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Neuron Projection Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Cytosol Glial Cell Development Scaffold Protein Binding Autophagy Of Mitochondrion Regulation Of Defense Response Intracellular Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Programmed Cell Death Cytoskeleton Protein Targeting Apoptotic Process Cellular Response To Catecholamine Stimulus Astrocyte Development Presynapse Programmed Cell Death Response To Catecholamine Synapse Response To Muramyl Dipeptide Regulation Of Innate Immune Response Positive Regulation Of Mitophagy SH3 Domain Binding Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Modulation Of Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Synaptic Transmission Protein Binding Developmental Process Regulation Of Mitotic Cell Cycle Organelle Organization	Intermediate Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Intermediate Filament Cytoskeleton Cellular Response To Rapamycin TORC1 Signaling Intermediate Filament Organization Regulation Of RNA Metabolic Process TOR Signaling Desmosome Response To Rapamycin Cell-cell Junction PML Body Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Cellular Response To Ether
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