ATP5F1B and HMOX2

Number of citations of the paper that reports this interaction (PubMedID 31536960)
63

Data Source:
BioGRID (biochemical, two hybrid)

		ATP5F1B	HMOX2
Description		ATP synthase F1 subunit beta	heme oxygenase 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Cell Surface Membrane Proton-transporting Two-sector ATPase Complex Mitochondrial Membrane Mitochondrial Nucleoid Proton-transporting ATP Synthase Complex Extracellular Exosome Transmembrane Transporter Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding MHC Class I Protein Binding Angiostatin Binding Metal Ion Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism	Heme Oxygenase (decyclizing) Activity Protein Binding Oxidoreductase Activity Heme Binding Metal Ion Binding
	Biological Process	Angiogenesis Osteoblast Differentiation Generation Of Precursor Metabolites And Energy Lipid Metabolic Process ATP Biosynthetic Process Monoatomic Ion Transport Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Proton Motive Force-driven ATP Synthesis Proton Motive Force-driven Mitochondrial ATP Synthesis Positive Regulation Of Blood Vessel Endothelial Cell Migration ATP Metabolic Process Regulation Of Intracellular PH Cellular Response To Interleukin-7 Proton Transmembrane Transport	Response To Hypoxia Heme Oxidation Response To Oxidative Stress Heme Catabolic Process
Pathways		Mitochondrial protein import Mitochondrial protein import Formation of ATP by chemiosmotic coupling Transcriptional activation of mitochondrial biogenesis Cristae formation Mitochondrial protein degradation	Heme degradation Neutrophil degranulation RHOA GTPase cycle Iron uptake and transport Cytoprotection by HMOX1
Drugs		Quercetin 1-ACETYL-2-CARBOXYPIPERIDINE AUROVERTIN B Piceatannol N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE Phenethyl Isothiocyanate	NADH Stannsoporfin
Diseases
GWAS			Erectile dysfunction ( 30583798)
Interacting Genes		29 interacting genes: ANXA7 APOA1 ATP5F1C ATPAF1 ATPAF2 BYSL CDK4 CDKN1A DOP1B DSCAM EIF4ENIF1 FANCA GRB7 HMOX2 HUNK LCOR LNX2 OGT PIN1 PLG PSME3 RPP14 SMN1 SUMO4 TERT TK1 TRIM55 TRIM63 YWHAG	67 interacting genes: A2M APP AQP6 ARL13B ASGR2 ATP5F1B BCL2L13 BIK BLOC1S2 CCR2 CD79A CEBPZ CEP126 COPS6 CRB3 CSNK2A1 EBP EEF1G EIF3C ELOVL4 ERGIC3 F2RL1 FAM209A FAM210B GET1 GIT1 GPR152 GPRASP1 GPX8 HAP1 IMMT INPP5K ITFG1 JADE1 KCNJ6 KCNMA1 LAPTM5 LRIF1 MED31 MGST3 MTNR1A NDUFS2 NKRF NR3C1 PCNT PLXNB2 PTGER4 RBBP4 RETREG3 RNASEK SAR1A SETDB1 SGPL1 SHC1 SKA2 SLC30A8 SMO SNX5 SNX7 SSMEM1 STOM SYT1 TMEM14B TMX2 VMA21 ZFP28 ZNF746
Entrez ID		506	3163
HPRD ID		00044	00783
Ensembl ID		ENSG00000110955	ENSG00000103415
Uniprot IDs		P06576 V9HW31	A0A087WT44 B3KSE0 P30519
PDB IDs		8H9E 8H9I 8H9L 8H9P 8H9S 8H9T 8H9U 8H9V 8KI3	2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA
Enriched GO Terms of Interacting Partners?		Mitochondrial Proton-transporting ATP Synthase Complex Assembly Proton-transporting ATP Synthase Complex Assembly	Membrane Protein Binding
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