ATP5F1B and GRB7

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		ATP5F1B	GRB7
Description		ATP synthase F1 subunit beta	growth factor receptor bound protein 7
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Cell Surface Membrane Proton-transporting Two-sector ATPase Complex Mitochondrial Membrane Mitochondrial Nucleoid Proton-transporting ATP Synthase Complex Extracellular Exosome Transmembrane Transporter Complex	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Membrane Cell Projection Anchoring Junction
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding MHC Class I Protein Binding Angiostatin Binding Metal Ion Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism	RNA Binding Protein Binding Lipid Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Angiogenesis Osteoblast Differentiation Generation Of Precursor Metabolites And Energy Lipid Metabolic Process ATP Biosynthetic Process Monoatomic Ion Transport Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Proton Motive Force-driven ATP Synthesis Proton Motive Force-driven Mitochondrial ATP Synthesis Positive Regulation Of Blood Vessel Endothelial Cell Migration ATP Metabolic Process Regulation Of Intracellular PH Cellular Response To Interleukin-7 Proton Transmembrane Transport	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly Negative Regulation Of Insulin Receptor Signaling Pathway
Pathways		Mitochondrial protein import Mitochondrial protein import Formation of ATP by chemiosmotic coupling Transcriptional activation of mitochondrial biogenesis Cristae formation Mitochondrial protein degradation	GRB7 events in ERBB2 signaling Signaling by SCF-KIT Downstream signal transduction Tie2 Signaling RET signaling RND1 GTPase cycle
Drugs		Quercetin 1-ACETYL-2-CARBOXYPIPERIDINE AUROVERTIN B Piceatannol N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE Phenethyl Isothiocyanate
Diseases
GWAS			Asthma ( 28461288 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Asthma with severe exacerbations ( 32841424) Crohn's disease ( 28067908) Height ( 31562340) Inflammatory bowel disease ( 28067908) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 20228799 28067908)
Interacting Genes		29 interacting genes: ANXA7 APOA1 ATP5F1C ATPAF1 ATPAF2 BYSL CDK4 CDKN1A DOP1B DSCAM EIF4ENIF1 FANCA GRB7 HMOX2 HUNK LCOR LNX2 OGT PIN1 PLG PSME3 RPP14 SMN1 SUMO4 TERT TK1 TRIM55 TRIM63 YWHAG	54 interacting genes: A1BG AGAP1 AR ATP5F1B CALM1 CAV1 CPNE6 CREBRF DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 ERBB4 FAM124B FCHO1 FGB FLAD1 GIGYF1 GIGYF2 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MET MSH2 PDGFRB PDHB PHAX PICK1 PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 STAC3 TCF12 TEK TGM5 TLE1 TMSB4X TRIM36 TRIM43 USP2 ZBTB16 ZNHIT1
Entrez ID		506	2886
HPRD ID		00044	03311
Ensembl ID		ENSG00000110955	ENSG00000141738
Uniprot IDs		P06576 V9HW31	A0A0S2Z4F6 Q14451
PDB IDs		8H9E 8H9I 8H9L 8H9P 8H9S 8H9T 8H9U 8H9V 8KI3	1MW4 1WGR 2L4K 2QMS 3PQZ 4WWQ 4X6S 5D0J 5EEL 5EEQ 5TYI 5U06 5U1Q 7MP3
Enriched GO Terms of Interacting Partners?		Mitochondrial Proton-transporting ATP Synthase Complex Assembly Proton-transporting ATP Synthase Complex Assembly	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Receptor Complex Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Protein Kinase Activity Kinase Activity Insulin-like Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Regulation Of Signal Transduction Regulation Of Cell Adhesion Animal Organ Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphate Metabolic Process ERBB2 Signaling Pathway Transferase Activity Focal Adhesion Positive Regulation Of Signal Transduction Regulation Of Cell Migration Regulation Of Programmed Cell Death Positive Regulation Of ERK1 And ERK2 Cascade Plasma Membrane Positive Regulation Of Protein Modification Process Cellular Developmental Process Regulation Of Cell Motility Regulation Of ERK1 And ERK2 Cascade Regulation Of Receptor Signaling Pathway Via JAK-STAT Nucleotide Binding ATP Binding Regulation Of Locomotion Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction Regulation Of Developmental Process
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