MKI67 and DRD4

Data Source: HiPPIP (Novel)

		MKI67	DRD4
Name		marker of proliferation Ki-67	dopamine receptor D4
Structure
GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Chromosome Nucleolus Membrane	Centrosome Plasma Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding Protein Binding ATP Binding Molecular Condensate Scaffold Activity	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Potassium Channel Regulator Activity SH3 Domain Binding Neurotransmitter Receptor Activity Dopamine Binding Identical Protein Binding Metal Ion Binding Epinephrine Binding Norepinephrine Binding
	Biological Process	Chromosome Segregation Regulation Of Mitotic Nuclear Division Cell Population Proliferation Regulation Of Chromatin Organization	Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission Adult Locomotory Behavior Adult Behavior Response To Histamine Social Behavior Regulation Of Dopamine Metabolic Process Fear Response Regulation Of Circadian Rhythm Positive Regulation Of MAPK Cascade Behavioral Response To Cocaine Behavioral Response To Ethanol Rhythmic Process Arachidonate Secretion Negative Regulation Of Protein Secretion Regulation Of Transport Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Inhibitory Postsynaptic Potential Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Primary Metabolic Process G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		None	Dopamine receptors G alpha (i) signalling events
Drugs		None	Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Sulpiride Loxapine Remoxipride Pramipexole Chlorpromazine Buspirone Amoxapine Lisuride Apomorphine Flupentixol Dopamine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Paliperidone Methotrimeprazine Flibanserin Iloperidone Rotigotine Asenapine Sumanirole Nandrolone decanoate Perospirone Pipamperone Epicriptine Pardoprunox Dihydroergocristine Aripiprazole lauroxil
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476 ) Drug experimentation measurement ( 30718321 ) Lead levels ( 26025379 ) Select biomarker traits ( 17903293 ) Suicide attempt severity in mood disorders ( 33783297 ) Triglyceride levels x loop diuretics use interaction ( 31806883 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: DRD4	4 novel interactors: CARS1 ETNK1 KIF2C MKI67
Interacting Genes		18 interacting genes: CBX3 CBX5 CDC20 CDH1 CDK1 CEBPA ECPAS HINFP KIF15 NIFK PPP1CA PRKCB PTEN SMN1 SUMO2 TK1 TRIM55 TRIM63	9 interacting genes: ADCY2 ADRB2 CLIC6 GABRA1 GNAI1 GRB2 KCNJ9 KLHL12 NCK1
Entrez ID		4288	1815
HPRD ID		08902	00541
Ensembl ID		ENSG00000148773	ENSG00000069696
Uniprot IDs		P46013	P21917
PDB IDs		1R21 2AFF 5J28	5WIU 5WIV
GO Terms Enriched among Interactors		DNA Synthesis Involved In Mitotic DNA Replication Chromatin Binding Rhythmic Process Thymidine Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Thymidine Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleoplasm Negative Regulation Of Cell Cycle Chromosome, Telomeric Region Regulation Of Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex Binding Identical Protein Binding Macromolecule Metabolic Process Mitotic Nuclear Membrane Disassembly Positive Regulation Of Proteolysis Ubiquitin Ligase Activator Activity Pyrimidine Nucleoside Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Postsynapse Spindle Nuclear Membrane Disassembly Cellular Response To Lithium Ion Response To Stress Membrane Disassembly Spindle Assembly Response To Lithium Ion Protein Modification Process Negative Regulation Of Cell Cycle Process PML Body Nucleus Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Primary Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Histone Deacetylase Binding Regulation Of Generation Of Precursor Metabolites And Energy Response To Glucocorticoid Response To Metal Ion Presynaptic Cytosol Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly Pericentric Heterochromatin Mitotic Cell Cycle Phase Transition Centrosome Macromolecule Biosynthetic Process Response To Corticosteroid Regulation Of Nucleobase-containing Compound Metabolic Process	D2 Dopamine Receptor Binding Adenylate Cyclase Binding Response To Forskolin Cellular Response To Forskolin Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Ephrin Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Chloride Channel Complex Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Actin Filament Polymerization Vesicle Membrane Molecular Condensate Scaffold Activity D4 Dopamine Receptor Binding Nucleotide Binding Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Regulation Of Biological Quality Regulation Of Organelle Organization Beta2-adrenergic Receptor Activity Cysteine-tRNA Ligase Activity Cysteinyl-tRNA Aminoacylation GABA Receptor Complex Chloride Channel Activity Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Protein Polymerization Grb2-EGFR Complex Ligand-gated Monoatomic Cation Channel Activity Positive Regulation Of Cap-independent Translational Initiation Eukaryotic Initiation Factor EIF2 Binding Positive Regulation Of Cap-dependent Translational Initiation D3 Dopamine Receptor Binding Ethanolamine Kinase Activity