MKI67

Name	marker of proliferation Ki-67
Structure
Novel Interactors	1 novel interactors: DRD4
Interactors	18 interactors: CBX3 CBX5 CDC20 CDH1 CDK1 CEBPA ECPAS HINFP KIF15 NIFK PPP1CA PRKCB PTEN SMN1 SUMO2 TK1 TRIM55 TRIM63
GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Chromosome Nucleolus Membrane
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding Protein Binding ATP Binding Molecular Condensate Scaffold Activity
	Biological Process	Chromosome Segregation Regulation Of Mitotic Nuclear Division Cell Population Proliferation Regulation Of Chromatin Organization
GWAS	Alzheimer's disease in APOE e4- carriers ( 25778476 ) Drug experimentation measurement ( 30718321 ) Lead levels ( 26025379 ) Select biomarker traits ( 17903293 ) Suicide attempt severity in mood disorders ( 33783297 ) Triglyceride levels x loop diuretics use interaction ( 31806883 )
Entrez ID	4288
HPRD ID	08902
Ensembl ID	ENSG00000148773
Uniprot IDs	P46013
PDB IDs	1R21 2AFF 5J28
GO Terms Enriched among Interactors ?	DNA Synthesis Involved In Mitotic DNA Replication Chromatin Binding Rhythmic Process Thymidine Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Thymidine Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleoplasm Negative Regulation Of Cell Cycle Chromosome, Telomeric Region Regulation Of Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex Binding Identical Protein Binding Macromolecule Metabolic Process Mitotic Nuclear Membrane Disassembly Positive Regulation Of Proteolysis Ubiquitin Ligase Activator Activity Pyrimidine Nucleoside Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Postsynapse Spindle Nuclear Membrane Disassembly Cellular Response To Lithium Ion Response To Stress Membrane Disassembly Spindle Assembly Response To Lithium Ion Protein Modification Process Negative Regulation Of Cell Cycle Process PML Body Nucleus Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Primary Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Histone Deacetylase Binding Regulation Of Generation Of Precursor Metabolites And Energy Response To Glucocorticoid Response To Metal Ion Presynaptic Cytosol Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly Pericentric Heterochromatin Mitotic Cell Cycle Phase Transition Centrosome Macromolecule Biosynthetic Process Response To Corticosteroid Regulation Of Nucleobase-containing Compound Metabolic Process