MKI67 and ECPAS

Number of citations of the paper that reports this interaction (PubMedID 20682791)
103

Data Source:
BioGRID (two hybrid)

		MKI67	ECPAS
Description		marker of proliferation Ki-67	Ecm29 proteasome adaptor and scaffold
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Chromosome Nucleolus Membrane	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Late Endosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Trans-Golgi Network Centrosome Cytoskeleton Membrane COPII-coated ER To Golgi Transport Vesicle Endocytic Vesicle Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding Protein Binding ATP Binding Molecular Condensate Scaffold Activity	Protein Binding Molecular Adaptor Activity Proteasome Binding
	Biological Process	Chromosome Segregation Regulation Of Mitotic Nuclear Division Cell Population Proliferation Regulation Of Chromatin Organization	ERAD Pathway Proteasome Assembly
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Drug experimentation measurement ( 30718321) Lead levels ( 26025379) Select biomarker traits ( 17903293) Suicide attempt severity in mood disorders ( 33783297) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		18 interacting genes: CBX3 CBX5 CDC20 CDH1 CDK1 CEBPA ECPAS HINFP KIF15 NIFK PPP1CA PRKCB PTEN SMN1 SUMO2 TK1 TRIM55 TRIM63	36 interacting genes: AGTRAP ANK2 ANKRD17 BSND CCDC57 CEBPA CEP170B CKS1B CMTM5 CMTM6 CPD DGAT2L6 DNAJB9 DST FBXO2 GAREM2 GOLGB1 HNRNPM HSD17B13 HSPB1 MAL2 MKI67 MYH10 PCM1 PCYT1B RAB11FIP4 RNF168 SF3B2 SPECC1L SYNE1 TNFRSF10D UBE2G2 UBE2Q1 UIMC1 VPS11 ZNF483
Entrez ID		4288	23392
HPRD ID		08902	11078
Ensembl ID		ENSG00000148773	ENSG00000136813
Uniprot IDs		P46013	A0AAA9X0G7 Q5VYK3
PDB IDs		1R21 2AFF 5J28
Enriched GO Terms of Interacting Partners?		DNA Synthesis Involved In Mitotic DNA Replication Chromatin Binding Rhythmic Process Thymidine Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Thymidine Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleoplasm Negative Regulation Of Cell Cycle Chromosome, Telomeric Region Regulation Of Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex Binding Identical Protein Binding Macromolecule Metabolic Process Mitotic Nuclear Membrane Disassembly Positive Regulation Of Proteolysis Ubiquitin Ligase Activator Activity Pyrimidine Nucleoside Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Postsynapse Spindle Nuclear Membrane Disassembly Cellular Response To Lithium Ion Response To Stress Membrane Disassembly Spindle Assembly Response To Lithium Ion Protein Modification Process Negative Regulation Of Cell Cycle Process PML Body Nucleus Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Primary Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Histone Deacetylase Binding Regulation Of Generation Of Precursor Metabolites And Energy Response To Glucocorticoid Response To Metal Ion Presynaptic Cytosol Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly Pericentric Heterochromatin Mitotic Cell Cycle Phase Transition Centrosome Macromolecule Biosynthetic Process Response To Corticosteroid Regulation Of Nucleobase-containing Compound Metabolic Process
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