TIMP1 and MYOC

Number of citations of the paper that reports this interaction (PMID 16289162)
20

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TIMP1	MYOC
Gene Name		TIMP metallopeptidase inhibitor 1	myocilin, trabecular meshwork inducible glucocorticoid response
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Cytoplasmic Vesicle Node Of Ranvier Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Cytokine Activity Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Metal Ion Binding	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding
	Biological Process	Platelet Degranulation Aging Blood Coagulation Positive Regulation Of Cell Proliferation Response To Hormone Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Response To Cytokine Negative Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Trophoblast Cell Migration Regulation Of Integrin-mediated Signaling Pathway	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Response to elevated platelet cytosolic Ca2+ Activation of Matrix Metalloproteinases Platelet degranulation Platelet activation, signaling and aggregation Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CD63 ECH1 EEF1B2 MMP1 MMP2 MMP3 MYOC RECQL5	40 interactors: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 TGFBR1 TIMP1 TKT TNFRSF1A
Entrez ID		7076	4653
HPRD ID		02371	03387
Ensembl ID		ENSG00000102265	ENSG00000034971
Uniprot IDs		B4DJK3 P01033 Q6FGX5	Q99972
PDB IDs		1D2B 1LQN 1OO9 1UEA 2J0T 3MA2 3V96
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Positive Regulation Of Protein Oligomerization Regulation Of Protein Oligomerization Positive Regulation Of Cellular Component Biogenesis Cellular Response To Amino Acid Stimulus Extracellular Matrix Organization Extracellular Structure Organization ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy Response To Amino Acid ERBB2 Signaling Pathway Regulation Of Protein Kinase B Signaling Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Complex Assembly Cellular Response To Acid Chemical Regulation Of Rubidium Ion Transport Catabolic Process Non-canonical Wnt Signaling Pathway Via JNK Cascade Non-canonical Wnt Signaling Pathway Via MAPK Cascade Regulation Of Cellular Component Organization Response To Stress Positive Regulation Of Oxidative Stress-induced Cell Death Clustering Of Voltage-gated Sodium Channels Pigment Granule Maturation Endosome To Melanosome Transport Intramembranous Ossification Skeletal Muscle Adaptation Bone Trabecula Formation Positive Regulation Of Integrin-mediated Signaling Pathway Cellular Pigment Accumulation Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Ossification Neuronal Ion Channel Clustering Blood Vessel Maturation Negative Regulation Of Actin Filament Bundle Assembly Cellular Response To Nitric Oxide Regulation Of Protein Complex Assembly Response To Nitric Oxide Bone Trabecula Morphogenesis Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Mitochondrial Depolarization Positive Regulation Of Receptor Internalization Negative Regulation Of DNA-templated Transcription, Elongation	Extracellular Matrix Organization Extracellular Structure Organization Platelet Activation Extracellular Matrix Disassembly Cell Activation Response To Wounding Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Cardiovascular System Development Collagen Fibril Organization System Development Developmental Process Blood Vessel Development Platelet Degranulation Multicellular Organismal Development Vasculature Development Glycolytic Process Organ Development Pyruvate Metabolic Process Pathogenesis Anatomical Structure Development Response To Stress Anatomical Structure Morphogenesis Monosaccharide Metabolic Process Carbohydrate Catabolic Process Locomotion Cell Development Glucose Metabolic Process Cell Differentiation Regulation Of Cellular Component Movement Vesicle-mediated Transport Response To Stimulus Movement Of Cell Or Subcellular Component Hexose Metabolic Process Immune System Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Skeletal System Development Platelet Aggregation Generation Of Precursor Metabolites And Energy Blood Vessel Morphogenesis Secretion Regulation Of Cell Motility Regulation Of Immune Response Organic Acid Metabolic Process Tissue Development Regulation Of Locomotion Cell Adhesion
Tagcloud ?		accurately another applying associations biomarker biomarkers candidate classifying divide egfr embedded escc esophageal ihc kit multivariate p110alpha p85alpha panel paraffin pi3k poor prognosis prognostic risks six squamous statistical subgroups	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Difference) ?		accurately another applying associations biomarker biomarkers candidate classifying divide egfr embedded escc esophageal ihc kit multivariate p110alpha p85alpha panel paraffin pi3k poor prognosis prognostic risks six squamous statistical subgroups	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Intersection) ?