TIMP1 and MMP2

Number of citations of the paper that reports this interaction (PubMedID 12475252)
0

Data Source:
HPRD (in vitro)

		TIMP1	MMP2
Description		TIMP metallopeptidase inhibitor 1	matrix metallopeptidase 2
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Plasma Membrane Membrane Sarcomere Extracellular Matrix
	Molecular Function	Protease Binding Enzyme Inhibitor Activity Cytokine Activity Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Zinc Ion Binding Peptidase Inhibitor Activity Metal Ion Binding	Fibronectin Binding Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Hormone Negative Regulation Of Endopeptidase Activity Response To Cytokine Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Response To Peptide Hormone Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cartilage Development Cellular Response To UV-A Negative Regulation Of Trophoblast Cell Migration Cellular Response To Peptide Negative Regulation Of Metallopeptidase Activity Regulation Of Integrin-mediated Signaling Pathway	Angiogenesis Ovarian Follicle Development Ovulation From Ovarian Follicle Luteinization Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Response To Oxidative Stress Negative Regulation Of Cell Adhesion Heart Development Female Pregnancy Embryo Implantation Parturition Response To Xenobiotic Stimulus Response To Mechanical Stimulus Peripheral Nervous System Axon Regeneration Response To Activity Cell Migration Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Retinoic Acid Response To Cytokine Cellular Response To Reactive Oxygen Species Response To Nicotine Endodermal Cell Differentiation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Response To Estrogen Negative Regulation Of Vasoconstriction Ephrin Receptor Signaling Pathway Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Skeletal System Morphogenesis Tissue Remodeling Response To Electrical Stimulus Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Prostate Gland Epithelium Morphogenesis Trophoblast Cell Migration Cellular Response To Amino Acid Stimulus Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-1 Cellular Response To Estradiol Stimulus Cellular Response To UV-A Cellular Response To Fluid Shear Stress Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Platelet degranulation Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation TGFBR3 PTM regulation	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling
Drugs			Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin Oleandrin
Diseases			Choriocarcinoma Penile cancer Torg-Winchester syndrome
GWAS			Heel bone mineral density ( 30598549) Lack of premeditation ( 30718321) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: CD63 ECH1 EEF1B2 MMP1 MMP2 MMP3 MYOC RECQL5 UBC	40 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CCN5 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		7076	4313
HPRD ID		02371	00386
Ensembl ID		ENSG00000102265	ENSG00000087245
Uniprot IDs		P01033 Q6FGX5	P08253
PDB IDs		1D2B 1OO9 1UEA 2J0T 3MA2 3V96 6MAV 6N9D 7S7L 7S7M	1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU 7XGJ 7XJO 8H78
Enriched GO Terms of Interacting Partners?		Cellular Response To UV-A Response To UV-A Collagen Catabolic Process Extracellular Matrix Disassembly Collagen Metabolic Process Metalloendopeptidase Activity Endopeptidase Activity Cellular Response To UV Cellular Response To Light Stimulus Metallopeptidase Activity Serine-type Endopeptidase Activity Response To UV Cellular Response To Radiation Fibronectin Binding Extracellular Structure Organization Extracellular Matrix Organization Pigment Granule Maturation Extracellular Space Delta(3,5)-delta(2,4)-dienoyl-CoA Isomerase Activity Response To Light Stimulus Response To Amyloid-beta Skeletal Muscle Hypertrophy Mitochondrion Cellular Response To Amino Acid Stimulus Regulation Of Cell Migration Mitotic DNA-templated DNA Replication Extracellular Matrix Regulation Of Cell Motility Response To Radiation Peptidase Activity Cellular Pigment Accumulation Regulation Of Locomotion Catabolic Process Cellular Response To Reactive Oxygen Species Mitotic DNA Replication Response To Amino Acid Positive Regulation Of Cellular Component Organization Cellular Pigmentation Eukaryotic Translation Elongation Factor 1 Complex Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Catalytic Activity, Acting On DNA Proteolysis Extracellular Region Multivesicular Body, Internal Vesicle Isomerase Activity Clustering Of Voltage-gated Sodium Channels Cellular Response To Camptothecin Platelet Dense Granule Membrane Intramembranous Ossification	Extracellular Matrix Extracellular Space Extracellular Region Peptidase Inhibitor Activity Protease Binding Metalloendopeptidase Inhibitor Activity Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Locomotion Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Protein Ectodomain Proteolysis Cell Adhesion Positive Regulation Of Developmental Process Response To Cytokine Response To Peptide Positive Regulation Of Mononuclear Cell Migration Response To Hormone Skeletal System Development Regulation Of Apoptotic Process Endoplasmic Reticulum Lumen Response To Mechanical Stimulus Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Cell Migration Extracellular Matrix Binding Regulation Of Mononuclear Cell Migration Integrin Binding Positive Regulation Of Leukocyte Migration Perineuronal Net Negative Regulation Of Multicellular Organismal Process Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength Response To Carbohydrate Regulation Of Proteolysis Regulation Of Developmental Process Basement Membrane Regulation Of Cell Junction Assembly Regulation Of Anatomical Structure Morphogenesis Cell Motility Extracellular Matrix Structural Constituent Conferring Compression Resistance Developmental Process Golgi Lumen Response To Xenobiotic Stimulus Negative Regulation Of Metallopeptidase Activity Angiogenesis
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