TIMP1 and RECQL5

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TIMP1	RECQL5
Gene Name		TIMP metallopeptidase inhibitor 1	RecQ protein-like 5
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm DNA-directed RNA Polymerase II, Holoenzyme Nuclear Membrane
	Molecular Function	Protease Binding Cytokine Activity Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Metal Ion Binding	RNA Polymerase II Core Binding Nucleic Acid Binding DNA Helicase Activity ATP Binding ATP-dependent Helicase Activity
	Biological Process	Platelet Degranulation Aging Blood Coagulation Positive Regulation Of Cell Proliferation Response To Hormone Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Response To Cytokine Negative Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Trophoblast Cell Migration Regulation Of Integrin-mediated Signaling Pathway	DNA Metabolic Process DNA Replication DNA Repair DNA Recombination Mitotic Nuclear Division DNA Duplex Unwinding Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cell Division Chromosome Separation
Pathways		Response to elevated platelet cytosolic Ca2+ Activation of Matrix Metalloproteinases Platelet degranulation Platelet activation, signaling and aggregation Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CD63 ECH1 EEF1B2 MMP1 MMP2 MMP3 MYOC RECQL5	19 interactors: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11A MTSS1 NBN PLK1 POLR2A RAD50 STAMBP TIMP1 TOP3A TOP3B
Entrez ID		7076	9400
HPRD ID		02371	04806
Ensembl ID		ENSG00000102265	ENSG00000108469
Uniprot IDs		B4DJK3 P01033 Q6FGX5	B3KQK2 O94762 Q6P4G0 Q8WYH5
PDB IDs		1D2B 1LQN 1OO9 1UEA 2J0T 3MA2 3V96	4BK0
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Positive Regulation Of Protein Oligomerization Regulation Of Protein Oligomerization Positive Regulation Of Cellular Component Biogenesis Cellular Response To Amino Acid Stimulus Extracellular Matrix Organization Extracellular Structure Organization ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy Response To Amino Acid ERBB2 Signaling Pathway Regulation Of Protein Kinase B Signaling Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Complex Assembly Cellular Response To Acid Chemical Regulation Of Rubidium Ion Transport Catabolic Process Non-canonical Wnt Signaling Pathway Via JNK Cascade Non-canonical Wnt Signaling Pathway Via MAPK Cascade Regulation Of Cellular Component Organization Response To Stress Positive Regulation Of Oxidative Stress-induced Cell Death Clustering Of Voltage-gated Sodium Channels Pigment Granule Maturation Endosome To Melanosome Transport Intramembranous Ossification Skeletal Muscle Adaptation Bone Trabecula Formation Positive Regulation Of Integrin-mediated Signaling Pathway Cellular Pigment Accumulation Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Ossification Neuronal Ion Channel Clustering Blood Vessel Maturation Negative Regulation Of Actin Filament Bundle Assembly Cellular Response To Nitric Oxide Regulation Of Protein Complex Assembly Response To Nitric Oxide Bone Trabecula Morphogenesis Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Mitochondrial Depolarization Positive Regulation Of Receptor Internalization Negative Regulation Of DNA-templated Transcription, Elongation	DNA Conformation Change Positive Regulation Of Protein Autophosphorylation Meiotic Cell Cycle Regulation Of Protein Autophosphorylation G2 DNA Damage Checkpoint Chromosome Organization Cellular Response To Stress Meiotic Nuclear Division Regulation Of Mitotic Recombination Telomere Maintenance Telomere Maintenance Via Telomerase DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cell Cycle Mitotic G2 DNA Damage Checkpoint Cell Cycle Process DNA Metabolic Process Mitotic Cell Cycle Process DNA Topological Change RNA-dependent DNA Replication Organelle Organization Double-strand Break Repair Mitotic Cell Cycle DNA Damage Checkpoint Regulation Of Kinase Activity Mitotic Cell Cycle Checkpoint Telomere Maintenance Via Telomere Lengthening Cellular Response To DNA Damage Stimulus Response To Stress Mitotic Cytokinesis Reciprocal Meiotic Recombination Negative Regulation Of Mitotic Cell Cycle Chromosome Segregation Cell Cycle Checkpoint DNA Recombination Positive Regulation Of Transferase Activity Reproduction DNA Repair Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of DNA Recombination Cellular Nitrogen Compound Metabolic Process Activation Of APC-Cdc20 Complex Activity Transcription, RNA-templated Glycine Betaine Biosynthetic Process From Choline Adherens Junction Maintenance Positive Regulation Of Cellular Metabolic Process Cell Proliferation
Tagcloud ?		accurately another applying associations biomarker biomarkers candidate classifying divide egfr embedded escc esophageal ihc kit multivariate p110alpha p85alpha panel paraffin pi3k poor prognosis prognostic risks six squamous statistical subgroups
Tagcloud (Difference) ?		accurately another applying associations biomarker biomarkers candidate classifying divide egfr embedded escc esophageal ihc kit multivariate p110alpha p85alpha panel paraffin pi3k poor prognosis prognostic risks six squamous statistical subgroups
Tagcloud (Intersection) ?