TIMP1 and CD63

Number of citations of the paper that reports this interaction (PubMedID 29523123)
86

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfer)
HPRD (two hybrid, in vivo)

		TIMP1	CD63
Description		TIMP metallopeptidase inhibitor 1	CD63 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Nucleoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Plasma Membrane Cell Surface Endosome Membrane Membrane Platelet Dense Granule Membrane Late Endosome Membrane Endosome Lumen Vesicle Multivesicular Body Membrane Protein-containing Complex Azurophil Granule Membrane Melanosome Extracellular Exosome Multivesicular Body, Internal Vesicle
	Molecular Function	Protease Binding Enzyme Inhibitor Activity Cytokine Activity Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Zinc Ion Binding Peptidase Inhibitor Activity Metal Ion Binding	Protein Binding Protein-containing Complex Binding
	Biological Process	Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Hormone Negative Regulation Of Endopeptidase Activity Response To Cytokine Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Response To Peptide Hormone Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cartilage Development Cellular Response To UV-A Negative Regulation Of Trophoblast Cell Migration Cellular Response To Peptide Negative Regulation Of Metallopeptidase Activity Regulation Of Integrin-mediated Signaling Pathway	Positive Regulation Of Receptor Internalization Cell-matrix Adhesion Negative Regulation Of Epithelial Cell Migration Protein Transport Cell Migration Cell Differentiation Epithelial Cell Differentiation Endosome To Melanosome Transport Pigmentation Positive Regulation Of Cell Adhesion Positive Regulation Of Endocytosis Pigment Granule Maturation Pigment Cell Differentiation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Platelet degranulation Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation TGFBR3 PTM regulation	Platelet degranulation Neutrophil degranulation
Drugs
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Cardiac Troponin-T levels ( 31014085) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: CD63 ECH1 EEF1B2 MMP1 MMP2 MMP3 MYOC RECQL5 UBC	18 interacting genes: AP4M1 CD82 CD9 F2RL1 GLP1R HLA-DMB HLA-DRA ITGA6 PI4K2A PTGFRN SDC1 SDCBP SLC22A1 SLC22A2 SRF TIMP1 TMEM80 VKORC1
Entrez ID		7076	967
HPRD ID		02371	01121
Ensembl ID		ENSG00000102265	ENSG00000135404
Uniprot IDs		P01033 Q6FGX5	P08962
PDB IDs		1D2B 1OO9 1UEA 2J0T 3MA2 3V96 6MAV 6N9D 7S7L 7S7M
Enriched GO Terms of Interacting Partners?		Cellular Response To UV-A Response To UV-A Collagen Catabolic Process Extracellular Matrix Disassembly Collagen Metabolic Process Metalloendopeptidase Activity Endopeptidase Activity Cellular Response To UV Cellular Response To Light Stimulus Metallopeptidase Activity Serine-type Endopeptidase Activity Response To UV Cellular Response To Radiation Fibronectin Binding Extracellular Structure Organization Extracellular Matrix Organization Pigment Granule Maturation Extracellular Space Delta(3,5)-delta(2,4)-dienoyl-CoA Isomerase Activity Response To Light Stimulus Response To Amyloid-beta Skeletal Muscle Hypertrophy Mitochondrion Cellular Response To Amino Acid Stimulus Regulation Of Cell Migration Mitotic DNA-templated DNA Replication Extracellular Matrix Regulation Of Cell Motility Response To Radiation Peptidase Activity Cellular Pigment Accumulation Regulation Of Locomotion Catabolic Process Cellular Response To Reactive Oxygen Species Mitotic DNA Replication Response To Amino Acid Positive Regulation Of Cellular Component Organization Cellular Pigmentation Eukaryotic Translation Elongation Factor 1 Complex Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Catalytic Activity, Acting On DNA Proteolysis Extracellular Region Multivesicular Body, Internal Vesicle Isomerase Activity Clustering Of Voltage-gated Sodium Channels Cellular Response To Camptothecin Platelet Dense Granule Membrane Intramembranous Ossification	Myoblast Fusion Involved In Skeletal Muscle Regeneration Positive Regulation Of Extracellular Exosome Assembly Acetylcholine Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Regulation Of Extracellular Exosome Assembly Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Membrane Serotonin Uptake Norepinephrine Transport Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Catecholamine Uptake Dopamine Uptake Azole Transmembrane Transport Serotonin Transport Skin Morphogenesis Quaternary Ammonium Group Transport Prostaglandin Transport Pyrimidine-containing Compound Transmembrane Transport Positive Regulation Of Exocytosis Peptide Antigen Assembly With MHC Class II Protein Complex Positive Regulation Of Exosomal Secretion MHC Class II Protein Complex Neurotransmitter Transmembrane Transporter Activity Vitamin Transmembrane Transport Organic Anion Transmembrane Transporter Activity Regulation Of Exosomal Secretion Regulation Of Body Fluid Levels Dopamine Transport Neurotransmitter Reuptake Xenobiotic Transmembrane Transporter Activity MHC Class II Protein Complex Binding Regulation Of Cell Migration Myoblast Fusion Monoamine Transport
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