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TIMP1
Description
TIMP metallopeptidase inhibitor 1
Image
GO Annotations
Cellular Component
Extracellular Region
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Platelet Alpha Granule Lumen
Secretory Granule Lumen
Extracellular Exosome
Molecular Function
Protease Binding
Enzyme Inhibitor Activity
Cytokine Activity
Protein Binding
Growth Factor Activity
Metalloendopeptidase Inhibitor Activity
Zinc Ion Binding
Peptidase Inhibitor Activity
Metal Ion Binding
Biological Process
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Response To Hormone
Negative Regulation Of Endopeptidase Activity
Response To Cytokine
Negative Regulation Of Apoptotic Process
Negative Regulation Of Catalytic Activity
Response To Peptide Hormone
Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Cartilage Development
Cellular Response To UV-A
Negative Regulation Of Trophoblast Cell Migration
Cellular Response To Peptide
Negative Regulation Of Metallopeptidase Activity
Regulation Of Integrin-mediated Signaling Pathway
Pathways
Platelet degranulation
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Post-translational protein phosphorylation
TGFBR3 PTM regulation
Drugs
Diseases
GWAS
Interacting Genes
9 interacting genes:
CD63
ECH1
EEF1B2
MMP1
MMP2
MMP3
MYOC
RECQL5
UBC
Entrez ID
7076
HPRD ID
02371
Ensembl ID
ENSG00000102265
Uniprot IDs
P01033
Q6FGX5
PDB IDs
1D2B
1OO9
1UEA
2J0T
3MA2
3V96
6MAV
6N9D
7S7L
7S7M
Enriched GO Terms of Interacting Partners
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Cellular Response To UV-A
Response To UV-A
Collagen Catabolic Process
Extracellular Matrix Disassembly
Collagen Metabolic Process
Metalloendopeptidase Activity
Endopeptidase Activity
Cellular Response To UV
Cellular Response To Light Stimulus
Metallopeptidase Activity
Serine-type Endopeptidase Activity
Response To UV
Cellular Response To Radiation
Fibronectin Binding
Extracellular Structure Organization
Extracellular Matrix Organization
Pigment Granule Maturation
Extracellular Space
Delta(3,5)-delta(2,4)-dienoyl-CoA Isomerase Activity
Response To Light Stimulus
Response To Amyloid-beta
Skeletal Muscle Hypertrophy
Mitochondrion
Cellular Response To Amino Acid Stimulus
Regulation Of Cell Migration
Mitotic DNA-templated DNA Replication
Extracellular Matrix
Regulation Of Cell Motility
Response To Radiation
Peptidase Activity
Cellular Pigment Accumulation
Regulation Of Locomotion
Catabolic Process
Cellular Response To Reactive Oxygen Species
Mitotic DNA Replication
Response To Amino Acid
Positive Regulation Of Cellular Component Organization
Cellular Pigmentation
Eukaryotic Translation Elongation Factor 1 Complex
Positive Regulation Of Cellular Component Biogenesis
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Catalytic Activity, Acting On DNA
Proteolysis
Extracellular Region
Multivesicular Body, Internal Vesicle
Isomerase Activity
Clustering Of Voltage-gated Sodium Channels
Cellular Response To Camptothecin
Platelet Dense Granule Membrane
Intramembranous Ossification
Tagcloud
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