TIMP1

Gene Name		TIMP metallopeptidase inhibitor 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Platelet Alpha Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Cytokine Activity Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Metal Ion Binding
	Biological Process	Platelet Degranulation Aging Blood Coagulation Positive Regulation Of Cell Proliferation Response To Hormone Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Response To Cytokine Negative Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Trophoblast Cell Migration Regulation Of Integrin-mediated Signaling Pathway
Pathways		Response to elevated platelet cytosolic Ca2+ Activation of Matrix Metalloproteinases Platelet degranulation Platelet activation, signaling and aggregation Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-protein Interactions		8 interactors: CD63 ECH1 EEF1B2 MMP1 MMP2 MMP3 MYOC RECQL5
Entrez ID		7076
HPRD ID		02371
Ensembl ID		ENSG00000102265
Uniprot IDs		B4DJK3 P01033 Q6FGX5
PDB IDs		1D2B 1LQN 1OO9 1UEA 2J0T 3MA2 3V96
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Positive Regulation Of Protein Oligomerization Regulation Of Protein Oligomerization Positive Regulation Of Cellular Component Biogenesis Cellular Response To Amino Acid Stimulus Extracellular Matrix Organization Extracellular Structure Organization ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy Response To Amino Acid ERBB2 Signaling Pathway Regulation Of Protein Kinase B Signaling Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Complex Assembly Cellular Response To Acid Chemical Regulation Of Rubidium Ion Transport Catabolic Process Non-canonical Wnt Signaling Pathway Via JNK Cascade Non-canonical Wnt Signaling Pathway Via MAPK Cascade Regulation Of Cellular Component Organization Response To Stress Positive Regulation Of Oxidative Stress-induced Cell Death Clustering Of Voltage-gated Sodium Channels Pigment Granule Maturation Endosome To Melanosome Transport Intramembranous Ossification Skeletal Muscle Adaptation Bone Trabecula Formation Positive Regulation Of Integrin-mediated Signaling Pathway Cellular Pigment Accumulation Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Ossification Neuronal Ion Channel Clustering Blood Vessel Maturation Negative Regulation Of Actin Filament Bundle Assembly Cellular Response To Nitric Oxide Regulation Of Protein Complex Assembly Response To Nitric Oxide Bone Trabecula Morphogenesis Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Mitochondrial Depolarization Positive Regulation Of Receptor Internalization Negative Regulation Of DNA-templated Transcription, Elongation
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