TIMP1 and MMP3

Number of citations of the paper that reports this interaction (PMID 9288970)
60

Data Source:
HPRD (in vitro)

		TIMP1	MMP3
Gene Name		TIMP metallopeptidase inhibitor 1	matrix metallopeptidase 3 (stromelysin 1, progelatinase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Mitochondrion Cytosol
	Molecular Function	Protease Binding Cytokine Activity Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Metal Ion Binding	Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Platelet Degranulation Aging Blood Coagulation Positive Regulation Of Cell Proliferation Response To Hormone Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Response To Cytokine Negative Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Trophoblast Cell Migration Regulation Of Integrin-mediated Signaling Pathway	Proteolysis Negative Regulation Of Hydrogen Peroxide Metabolic Process Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Regulation Of Cell Migration Collagen Catabolic Process Positive Regulation Of Protein Oligomerization Negative Regulation Of Protein Kinase B Signaling Cellular Response To Amino Acid Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Oxidative Stress-induced Cell Death
Pathways		Response to elevated platelet cytosolic Ca2+ Activation of Matrix Metalloproteinases Platelet degranulation Platelet activation, signaling and aggregation Degradation of the extracellular matrix	Signaling by GPCR EGFR Transactivation by Gastrin Collagen formation Collagen degradation Gastrin-CREB signalling pathway via PKC and MAPK Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs			Marimastat N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4-(Z,E-N-Methoxyimino)Pyrrolidine-2r-Carboxamide 3-Methylpyridine A Disubstituted Succinyl Caprolactam Hydroxymate Mmp3inhibitor N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl]-2,2-Dimethyl-Hexahydro-1,4-Thiazepine-3(S)-Carboxamide (1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hydroxycarboxamido-(4s)-Methanesulfonylamino-Pyrrolidine 3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperidin-1-Yl)-Benzenesulfonylamino]-Propionic Acid Hydroxyaminovaline 1-Methyloxy-4-Sulfone-Benzene 5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine-2,4,6-Trione 1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6-Oxo-Hexahydro-Pyrimidine-4-Carboxylic Acid Hydroxyamide N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4-Benzyloxycarbonyl-Piperazine-2-Carboxamide R-2-{[4\'-Methoxy-(1,1\'-Biphenyl)-4-Yl]-Sulfonyl}-Amino-6-Methoxy-Hex-4-Ynoic Acid 2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YL)-UREIDO]-N-METHYL-3-PHENYL-PROPIONAMIDE [4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULFONYLAMINO]-ACETIC ACID [2-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YLCARBAMOYL)-1-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER 2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2YL)-UREIDO]-N-METHYL-3-PENTAFLUOROPHENYL-PROPIONAMIDE N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N~2~-(2-hydroxyethyl)glycinamide 3-[(4\'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamide N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID 2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3-MERCAPTO-PENTANOYLAMINO}-ACETYLAMINO)-3-METHYL-BUTYRIC ACID METHYL ESTER
Diseases
GWAS			Alzheimer's disease ( 22832961)
Protein-Protein Interactions		8 interactors: CD63 ECH1 EEF1B2 MMP1 MMP2 MMP3 MYOC RECQL5	18 interactors: ACAN BCAN CCL13 CCL2 CCL7 CCL8 DCN HAPLN1 IGFBP3 MEOX2 PLG SERPINE1 SPOCK1 SPOCK3 SPP1 TIMP1 TIMP3 TNFSF11
Entrez ID		7076	4314
HPRD ID		02371	01703
Ensembl ID		ENSG00000102265	ENSG00000149968
Uniprot IDs		B4DJK3 P01033 Q6FGX5	P08254
PDB IDs		1D2B 1LQN 1OO9 1UEA 2J0T 3MA2 3V96	1B3D 1B8Y 1BIW 1BM6 1BQO 1C3I 1C8T 1CAQ 1CIZ 1CQR 1D5J 1D7X 1D8F 1D8M 1G05 1G49 1G4K 1HFS 1HY7 1M1W 1OO9 1QIA 1QIC 1SLM 1SLN 1UEA 1UMS 1UMT 1USN 2D1O 2JNP 2JT5 2JT6 2SRT 2USN 3OHL 3OHO 3USN 4DPE 4G9L 4JA1
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Positive Regulation Of Protein Oligomerization Regulation Of Protein Oligomerization Positive Regulation Of Cellular Component Biogenesis Cellular Response To Amino Acid Stimulus Extracellular Matrix Organization Extracellular Structure Organization ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy Response To Amino Acid ERBB2 Signaling Pathway Regulation Of Protein Kinase B Signaling Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Complex Assembly Cellular Response To Acid Chemical Regulation Of Rubidium Ion Transport Catabolic Process Non-canonical Wnt Signaling Pathway Via JNK Cascade Non-canonical Wnt Signaling Pathway Via MAPK Cascade Regulation Of Cellular Component Organization Response To Stress Positive Regulation Of Oxidative Stress-induced Cell Death Clustering Of Voltage-gated Sodium Channels Pigment Granule Maturation Endosome To Melanosome Transport Intramembranous Ossification Skeletal Muscle Adaptation Bone Trabecula Formation Positive Regulation Of Integrin-mediated Signaling Pathway Cellular Pigment Accumulation Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Ossification Neuronal Ion Channel Clustering Blood Vessel Maturation Negative Regulation Of Actin Filament Bundle Assembly Cellular Response To Nitric Oxide Regulation Of Protein Complex Assembly Response To Nitric Oxide Bone Trabecula Morphogenesis Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Mitochondrial Depolarization Positive Regulation Of Receptor Internalization Negative Regulation Of DNA-templated Transcription, Elongation	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Cell Chemotaxis Leukocyte Migration Leukocyte Chemotaxis Cell Migration Granulocyte Chemotaxis Cell Motility Monocyte Chemotaxis Proteoglycan Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Locomotion Calcium Ion Homeostasis Chemotaxis Regulation Of Cell Adhesion Negative Regulation Of Proteolysis Movement Of Cell Or Subcellular Component Negative Regulation Of Protein Processing Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Glycosaminoglycan Metabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Chondroitin Sulfate Metabolic Process Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Regulation Of Peptidase Activity Inflammatory Response Regulation Of Cell-substrate Adhesion Developmental Process Negative Regulation Of Cell Migration Eosinophil Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of Cell Motility Negative Regulation Of Cellular Protein Metabolic Process Metal Ion Homeostasis Regulation Of Catalytic Activity Platelet Degranulation Eosinophil Migration Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Negative Regulation Of Cellular Component Movement Response To External Stimulus Negative Regulation Of Fibrinolysis Positive Regulation Of Monocyte Chemotaxis Dermatan Sulfate Biosynthetic Process Negative Regulation Of Locomotion
Tagcloud ?		accurately another applying associations biomarker biomarkers candidate classifying divide egfr embedded escc esophageal ihc kit multivariate p110alpha p85alpha panel paraffin pi3k poor prognosis prognostic risks six squamous statistical subgroups	6j adp articular blotting c57bl chondrocyte chondrocytes degeneration eicosapentaenoic epa inc intra metalloproteinases mmp13 mmps nitroprusside oa orthop orthopaedic osteoarthritis periodicals poly polyunsaturated reduces res ribose snp society wiley
Tagcloud (Difference) ?		accurately another applying associations biomarker biomarkers candidate classifying divide egfr embedded escc esophageal ihc kit multivariate p110alpha p85alpha panel paraffin pi3k poor prognosis prognostic risks six squamous statistical subgroups	6j adp articular blotting c57bl chondrocyte chondrocytes degeneration eicosapentaenoic epa inc intra metalloproteinases mmp13 mmps nitroprusside oa orthop orthopaedic osteoarthritis periodicals poly polyunsaturated reduces res ribose snp society wiley
Tagcloud (Intersection) ?