TIMP1 and ECH1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		TIMP1	ECH1
Gene Name		TIMP metallopeptidase inhibitor 1	enoyl CoA hydratase 1, peroxisomal
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Mitochondrion Peroxisome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Cytokine Activity Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Metal Ion Binding	Receptor Binding Protein Binding Isomerase Activity
	Biological Process	Platelet Degranulation Aging Blood Coagulation Positive Regulation Of Cell Proliferation Response To Hormone Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Response To Cytokine Negative Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Trophoblast Cell Migration Regulation Of Integrin-mediated Signaling Pathway	Fatty Acid Beta-oxidation
Pathways		Response to elevated platelet cytosolic Ca2+ Activation of Matrix Metalloproteinases Platelet degranulation Platelet activation, signaling and aggregation Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CD63 ECH1 EEF1B2 MMP1 MMP2 MMP3 MYOC RECQL5	13 interactors: APP CSTF2 EEF1D EEF1G FAM9B HTT PAFAH1B3 PEX5 SERPINB9 STAT3 TIMP1 TLR10 TRAF1
Entrez ID		7076	1891
HPRD ID		02371	02825
Ensembl ID		ENSG00000102265	ENSG00000104823
Uniprot IDs		B4DJK3 P01033 Q6FGX5	Q13011
PDB IDs		1D2B 1LQN 1OO9 1UEA 2J0T 3MA2 3V96	2VRE
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Positive Regulation Of Protein Oligomerization Regulation Of Protein Oligomerization Positive Regulation Of Cellular Component Biogenesis Cellular Response To Amino Acid Stimulus Extracellular Matrix Organization Extracellular Structure Organization ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy Response To Amino Acid ERBB2 Signaling Pathway Regulation Of Protein Kinase B Signaling Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Complex Assembly Cellular Response To Acid Chemical Regulation Of Rubidium Ion Transport Catabolic Process Non-canonical Wnt Signaling Pathway Via JNK Cascade Non-canonical Wnt Signaling Pathway Via MAPK Cascade Regulation Of Cellular Component Organization Response To Stress Positive Regulation Of Oxidative Stress-induced Cell Death Clustering Of Voltage-gated Sodium Channels Pigment Granule Maturation Endosome To Melanosome Transport Intramembranous Ossification Skeletal Muscle Adaptation Bone Trabecula Formation Positive Regulation Of Integrin-mediated Signaling Pathway Cellular Pigment Accumulation Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Ossification Neuronal Ion Channel Clustering Blood Vessel Maturation Negative Regulation Of Actin Filament Bundle Assembly Cellular Response To Nitric Oxide Regulation Of Protein Complex Assembly Response To Nitric Oxide Bone Trabecula Morphogenesis Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Mitochondrial Depolarization Positive Regulation Of Receptor Internalization Negative Regulation Of DNA-templated Transcription, Elongation	Regulation Of Developmental Growth Regulation Of Multicellular Organism Growth Protein Import Central Nervous System Development MRNA Polyadenylation Response To Estrogen RNA Polyadenylation Regulation Of Growth Endoplasmic Reticulum Organization Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Axon Cargo Transport Mating Negative Regulation Of Neurogenesis Mitochondrial Membrane Organization Neuron Apoptotic Process Brain Development Visual Learning Sexual Reproduction Head Development Visual Behavior Neuron Death Neural Plate Formation Negative Regulation Of Cell Development Platelet Degranulation Regulation Of Cell Death Negative Regulation Of Proteolysis Establishment Of Protein Localization To Organelle Negative Regulation Of Protein Processing MRNA 3'-end Processing Associative Learning Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Response To Hormone Regulation Of Peptidase Activity Negative Regulation Of Protein Homotetramerization Synaptic Growth At Neuromuscular Junction Serotonin Uptake Lactate Biosynthetic Process From Pyruvate Apoptotic Process Negative Regulation Of Cell Death Protein Targeting Feeding Behavior Programmed Cell Death Forebrain Development Regulation Of Signal Transduction RNA 3'-end Processing Reproduction Cell Death
Tagcloud ?		accurately another applying associations biomarker biomarkers candidate classifying divide egfr embedded escc esophageal ihc kit multivariate p110alpha p85alpha panel paraffin pi3k poor prognosis prognostic risks six squamous statistical subgroups	33k butylhydroperoxide choline coa disturbed enoyl galactosidase hayflick hmsc hmscs hydratase hyperoxia inducer metabolites mlc2 myosin p30 peroxisomal premature prosomal psma1 replicative senescence shares shortening sips spots sublethal tert
Tagcloud (Difference) ?		accurately another applying associations biomarker biomarkers candidate classifying divide egfr embedded escc esophageal ihc kit multivariate p110alpha p85alpha panel paraffin pi3k poor prognosis prognostic risks six squamous statistical subgroups	33k butylhydroperoxide choline coa disturbed enoyl galactosidase hayflick hmsc hmscs hydratase hyperoxia inducer metabolites mlc2 myosin p30 peroxisomal premature prosomal psma1 replicative senescence shares shortening sips spots sublethal tert
Tagcloud (Intersection) ?