TEK and SOCS1

Number of citations of the paper that reports this interaction (PMID 10022833)
24

Data Source:
HPRD (two hybrid)

		TEK	SOCS1
Gene Name		TEK tyrosine kinase, endothelial	suppressor of cytokine signaling 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Extracellular Region Actin Filament Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cell-cell Junction Focal Adhesion Basal Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Membrane Raft Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Activity Protein Binding ATP Binding Growth Factor Binding	Protein Kinase Inhibitor Activity Insulin-like Growth Factor Receptor Binding Protein Binding Kinase Inhibitor Activity Protein Kinase Binding
	Biological Process	Angiogenesis Response To Hypoxia Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Sprouting Angiogenesis Positive Regulation Of Cytokine Secretion Involved In Immune Response Cell-matrix Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Heart Development Blood Coagulation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Single Organismal Cell-cell Adhesion Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Organ Regeneration Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Peptidyl-serine Phosphorylation Substrate Adhesion-dependent Cell Spreading Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Response To Peptide Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Estrogen Positive Regulation Of Angiogenesis Protein Autophosphorylation Tie Signaling Pathway Negative Regulation Of Inflammatory Response Leukocyte Migration Protein Oligomerization Response To CAMP Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Definitive Hemopoiesis Heart Trabecula Formation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Actin Cytoskeleton Reorganization Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process	Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Fat Cell Differentiation Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Amino Acid Stimulus
Pathways		Tie2 Signaling Cell surface interactions at the vascular wall	Regulation of IFNA signaling Antigen processing: Ubiquitination & Proteasome degradation Interferon Signaling Cytokine Signaling in Immune system Toll Like Receptor TLR6:TLR2 Cascade Signaling by SCF-KIT Toll Like Receptor 2 (TLR2) Cascade Interferon gamma signaling Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Regulation of KIT signaling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Regulation of IFNG signaling Innate Immune System Growth hormone receptor signaling Adaptive Immune System
Drugs
Diseases
GWAS			Bulimia nervosa ( 23568457) Celiac disease ( 20190752) Crohn's disease and psoriasis ( 22482804) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		20 interactors: ANGPT1 ANGPT2 ANGPT4 ANGPTL1 APP DOK2 DOK4 GRB14 GRB2 GRB7 IKBKG PIK3R1 PTPN11 PTPRB SHC1 SOCS1 STAT5A STAT5B TIE1 TNIP2	40 interactors: ATM AXL COMMD1 CRK CSF1 CSF1R CXCR4 CYTIP EGFR ERBB2 FLT3 FYN GHR GRB2 IFNGR1 IGF1R IL2RB INSR IRS1 IRS2 ITK JAK1 JAK2 JAK3 KIT MPL NCK1 PDGFRB PIK3R1 PIK3R2 PIM2 RELA TCEB1 TCEB2 TEC TEK TIRAP TRIM8 VAV1 VAV2
Entrez ID		7010	8651
HPRD ID		02571	04669
Ensembl ID		ENSG00000120156	ENSG00000185338
Uniprot IDs		Q02763 Q59HG2	O15524 Q4JHT5
PDB IDs		1FVR 2GY5 2GY7 2OO8 2OSC 2P4I 2WQB 3BEA 3L8P 4K0V
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Body Fluid Levels Enzyme Linked Receptor Protein Signaling Pathway Leukocyte Migration Blood Coagulation Hemostasis Immune System Process Signal Transduction Wound Healing Signaling Cell Communication Cell Surface Receptor Signaling Pathway Response To Wounding Cellular Response To Stimulus Cell Migration Regulation Of Immune Response Response To Stimulus Cell Motility Locomotion Response To Stress Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Growth Hormone Stimulus Cellular Response To Peptide Movement Of Cell Or Subcellular Component Positive Regulation Of Signal Transduction Regulation Of Immune System Process Regulation Of Signal Transduction Response To Growth Hormone Regulation Of Innate Immune Response Intracellular Signal Transduction Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signaling Regulation Of Kinase Activity Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Angiogenesis ERBB Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Phosphorylation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Defense Response Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Development Of Secondary Male Sexual Characteristics JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Protein Autophosphorylation Immune Response Regulation Of Immune System Process Immune System Process Defense Response Positive Regulation Of Signal Transduction Cellular Response To Organic Substance Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Response To Stress Phosphatidylinositol-mediated Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Metabolic Process Neurotrophin Signaling Pathway Regulation Of Cell Proliferation Regulation Of Phosphorylation Cellular Response To Hormone Stimulus Signal Transduction Regulation Of Phosphorus Metabolic Process Response To Hormone Cell Activation Cellular Response To Stimulus Response To Peptide Hormone Cellular Response To Growth Factor Stimulus Signaling Response To Growth Factor Response To Peptide Cell Communication Positive Regulation Of Kinase Activity Response To Stimulus Peptidyl-tyrosine Autophosphorylation Cellular Response To Peptide Hormone Stimulus Peptidyl-amino Acid Modification Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		amplify blk bpk cdnas cmet degenerate eck f1 fer fes fgr flk fyn hck kit lacked lin ly6a ptks rtk rtks ryk sca sixteen sorted sorter stk turned tyk	1beta acylethanolamines administration amide anandamide attenuated central comparison concurrently downstream enhancing faah fatty hippocampal hydrolase ifnalpha ifngamma ip neuroinflammation neuroinflammatory oleoylethanolamide palmitoylethanolamide substrate systemic tlr tlr3 tnfalpha toll urb597
Tagcloud (Difference) ?		amplify blk bpk cdnas cmet degenerate eck f1 fer fes fgr flk fyn hck kit lacked lin ly6a ptks rtk rtks ryk sca sixteen sorted sorter stk turned tyk	1beta acylethanolamines administration amide anandamide attenuated central comparison concurrently downstream enhancing faah fatty hippocampal hydrolase ifnalpha ifngamma ip neuroinflammation neuroinflammatory oleoylethanolamide palmitoylethanolamide substrate systemic tlr tlr3 tnfalpha toll urb597
Tagcloud (Intersection) ?