TEK and ANGPT4

Number of citations of the paper that reports this interaction (PubMedID 10051567)
18

Data Source:
HPRD (in vivo, in vitro)

		TEK	ANGPT4
Description		TEK receptor tyrosine kinase	angiopoietin 4
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Extracellular Region Cytoplasm Centrosome Cytoskeleton Actin Filament Plasma Membrane Microvillus Cell-cell Junction Focal Adhesion Basal Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Ciliary Basal Body Receptor Complex Membrane Raft Anchoring Junction	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Signaling Receptor Activity Identical Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding
	Biological Process	Angiogenesis Endothelial Cell Proliferation Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Heart Development Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Hemopoiesis Regulation Of Cell Migration Cell-substrate Adhesion Regulation Of Establishment Or Maintenance Of Cell Polarity Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Positive Regulation Of MAPK Cascade Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Tie Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Definitive Hemopoiesis Heart Trabecula Formation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Glomerulus Vasculature Development Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process	Angiogenesis Endothelial Cell Proliferation Signal Transduction Notch Signaling Pathway Blood Coagulation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Hypoxia
Pathways		Tie2 Signaling Tie2 Signaling RAF/MAP kinase cascade	Tie2 Signaling
Drugs		Ampicillin Vandetanib N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE Regorafenib Ponatinib Tivozanib Fostamatinib Ripretinib
Diseases		Venous malformations, including: Sporadic venous malformation; Cutaneomucosal venous malformation; Glomuvenous malformation
GWAS		Adult asthma ( 27611488) Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Asthma ( 27611488) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Cognitive decline (age-related) ( 28078323) Coronary artery disease ( 29212778) Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821)	Food allergy ( 29030101) Intracranial aneurysm ( 29531279) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321) Lung function ( 31902109) Peanut allergy ( 29030101)
Interacting Genes		26 interacting genes: ANGPT1 ANGPT2 ANGPT4 ANGPTL1 APP CAV1 DOK2 DOK4 DUSP18 GRB14 GRB2 GRB7 IKBKG ILKAP PIK3R1 PTPN11 PTPRB PTPRR SHC1 SHC4 SOCS1 STAT5A STAT5B STYX TIE1 TNIP2	3 interacting genes: RHOU TEK TIE1
Entrez ID		7010	51378
HPRD ID		02571	04747
Ensembl ID		ENSG00000120156	ENSG00000101280
Uniprot IDs		Q02763 Q59HG2	Q9Y264
PDB IDs		1FVR 2GY5 2GY7 2OO8 2OSC 2P4I 2WQB 3BEA 3L8P 4K0V 4X3J 5MYA 5MYB 5UTK 6MWE 7E72
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Receptor Tyrosine Kinase Binding Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin Receptor Binding Negative Regulation Of Developmental Process Neurotrophin TRKA Receptor Binding Positive Regulation Of Cell Activation ERBB Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Cell Adhesion Regulation Of Body Fluid Levels Positive Regulation Of Multicellular Organismal Process Regulation Of Innate Immune Response Angiogenesis Regulation Of MAPK Cascade Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Activation Natural Killer Cell Mediated Immunity Phosphotyrosine Residue Binding Regulation Of Cell Migration Positive Regulation Of Immune System Process Regulation Of Cell Motility Regulation Of Locomotion Anatomical Structure Formation Involved In Morphogenesis Insulin-like Growth Factor Receptor Binding Phosphoprotein Phosphatase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of T Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of ERK1 And ERK2 Cascade Protein Kinase Binding Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Regulation Of Insulin Receptor Signaling Pathway Leukocyte Mediated Cytotoxicity Regulation Of Cellular Response To Insulin Stimulus Regulation Of Signal Transduction Negative Regulation Of Cell Adhesion Response To Growth Factor Regulation Of Immune Response Growth Hormone Receptor Signaling Pathway Development Of Secondary Female Sexual Characteristics	Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Cell-substrate Junction Organization Blood Vessel Development Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Protein Tyrosine Kinase Activity Regulation Of Endothelial Cell Proliferation Branching Involved In Lymph Vessel Morphogenesis Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Receptor Complex Tie Signaling Pathway Nucleotide Binding Regulation Of Angiogenesis Glomerulus Vasculature Development Regulation Of Small GTPase Mediated Signal Transduction Angiogenesis Regulation Of Vasculature Development Lymphatic Endothelial Cell Differentiation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Focal Adhesion Disassembly Anchoring Junction Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Heart Trabecula Formation Protein Kinase Activity Regulation Of Developmental Process Definitive Hemopoiesis Regulation Of Cellular Component Organization Positive Regulation Of Rac Protein Signal Transduction Plasma Membrane Fusion Kinase Activity Regulation Of Extracellular Matrix Assembly Enzyme-linked Receptor Protein Signaling Pathway Rac Protein Signal Transduction Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Focal Adhesion Assembly Endothelial Cell Differentiation Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Apoptotic Process Endothelial Cell Proliferation Regulation Of Rac Protein Signal Transduction Anatomical Structure Formation Involved In Morphogenesis Aortic Valve Morphogenesis Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Podosome Regulation Of Protein Targeting To Mitochondrion
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