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TEK and TNIP2
Number of citations of the paper that reports this interaction (PMID
12609966
)
15
Data Source:
HPRD
(two hybrid, in vivo)
TEK
TNIP2
Gene Name
TEK tyrosine kinase, endothelial
TNFAIP3 interacting protein 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Stress Fiber
Extracellular Region
Actin Filament
Plasma Membrane
Integral Component Of Plasma Membrane
Microvillus
Cell-cell Junction
Focal Adhesion
Basal Plasma Membrane
Cell Surface
Basolateral Plasma Membrane
Apical Plasma Membrane
Membrane Raft
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Receptor Activity
Protein Binding
ATP Binding
Growth Factor Binding
Protein Binding
Protein Kinase Binding
Polyubiquitin Binding
Biological Process
Angiogenesis
Response To Hypoxia
Positive Regulation Of Protein Phosphorylation
Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Endochondral Ossification
Sprouting Angiogenesis
Positive Regulation Of Cytokine Secretion Involved In Immune Response
Cell-matrix Adhesion
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell-cell Signaling
Heart Development
Blood Coagulation
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Single Organismal Cell-cell Adhesion
Negative Regulation Of Angiogenesis
Peptidyl-tyrosine Phosphorylation
Organ Regeneration
Regulation Of Establishment Or Maintenance Of Cell Polarity
Positive Regulation Of Peptidyl-serine Phosphorylation
Substrate Adhesion-dependent Cell Spreading
Intracellular Signal Transduction
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of Apoptotic Process
Regulation Of Vascular Permeability
Response To Peptide Hormone
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Response To Estrogen
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Tie Signaling Pathway
Negative Regulation Of Inflammatory Response
Leukocyte Migration
Protein Oligomerization
Response To CAMP
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Definitive Hemopoiesis
Heart Trabecula Formation
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Actin Cytoskeleton Reorganization
Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Endothelial Cell Apoptotic Process
Transcription, DNA-templated
Apoptotic Process
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
CD40 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Positive Regulation Of Macrophage Activation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Protein Stabilization
Positive Regulation Of B Cell Activation
Interleukin-1-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
Tie2 Signaling
Cell surface interactions at the vascular wall
Signaling by Interleukins
Cytokine Signaling in Immune system
Interleukin-1 signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions
20 interactors:
ANGPT1
ANGPT2
ANGPT4
ANGPTL1
APP
DOK2
DOK4
GRB14
GRB2
GRB7
IKBKG
PIK3R1
PTPN11
PTPRB
SHC1
SOCS1
STAT5A
STAT5B
TIE1
TNIP2
23 interactors:
APP
CDKN1A
CHUK
EP300
FBXO25
FLNA
IKBKG
MAP3K8
MAPK1
MKNK1
NCOR2
NFKB1
NFKB2
PDCD6IP
PSMD9
REL
RELA
SMARCD1
SRPK2
STK11
TEK
TNFAIP3
UBC
Entrez ID
7010
79155
HPRD ID
02571
18207
Ensembl ID
ENSG00000120156
ENSG00000168884
Uniprot IDs
Q02763
Q59HG2
D6RGJ2
Q8NFZ5
PDB IDs
1FVR
2GY5
2GY7
2OO8
2OSC
2P4I
2WQB
3BEA
3L8P
4K0V
Enriched GO Terms of Interacting Partners
?
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Body Fluid Levels
Enzyme Linked Receptor Protein Signaling Pathway
Leukocyte Migration
Blood Coagulation
Hemostasis
Immune System Process
Signal Transduction
Wound Healing
Signaling
Cell Communication
Cell Surface Receptor Signaling Pathway
Response To Wounding
Cellular Response To Stimulus
Cell Migration
Regulation Of Immune Response
Response To Stimulus
Cell Motility
Locomotion
Response To Stress
Growth Hormone Receptor Signaling Pathway
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Growth Hormone Stimulus
Cellular Response To Peptide
Movement Of Cell Or Subcellular Component
Positive Regulation Of Signal Transduction
Regulation Of Immune System Process
Regulation Of Signal Transduction
Response To Growth Hormone
Regulation Of Innate Immune Response
Intracellular Signal Transduction
Response To Peptide Hormone
Cellular Response To Organonitrogen Compound
Response To Peptide
Regulation Of Signaling
Regulation Of Kinase Activity
Positive Regulation Of Cell Activation
Epidermal Growth Factor Receptor Signaling Pathway
Angiogenesis
ERBB Signaling Pathway
Cellular Response To Hormone Stimulus
Regulation Of Phosphorylation
Positive Regulation Of Cell Adhesion
Regulation Of Cell Adhesion
Defense Response
Regulation Of Lymphocyte Activation
Positive Regulation Of T Cell Activation
Regulation Of Peptidyl-tyrosine Phosphorylation
Development Of Secondary Male Sexual Characteristics
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Intracellular Signal Transduction
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Innate Immune Response
Regulation Of Type I Interferon Production
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Immune System Process
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
MyD88-dependent Toll-like Receptor Signaling Pathway
Apoptotic Process
Activation Of Innate Immune Response
Positive Regulation Of Type I Interferon Production
Toll-like Receptor 4 Signaling Pathway
Programmed Cell Death
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Cell Death
Death
Positive Regulation Of Cellular Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Innate Immune Response
Immune Response-regulating Signaling Pathway
Positive Regulation Of Immune System Process
Toll-like Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Response To Stress
I-kappaB Kinase/NF-kappaB Signaling
Immune Response
Positive Regulation Of Cytokine Production
Regulation Of Cytokine Production
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Defense Response
Antigen Receptor-mediated Signaling Pathway
Regulation Of Innate Immune Response
Signal Transduction
Regulation Of Immune Response
Positive Regulation Of Immune Response
Positive Regulation Of Gene Expression
NIK/NF-kappaB Signaling
Positive Regulation Of Protein Metabolic Process
Signaling
Positive Regulation Of Cellular Biosynthetic Process
Tagcloud
?
amplify
blk
bpk
cdnas
cmet
degenerate
eck
f1
fer
fes
fgr
flk
fyn
hck
kit
lacked
lin
ly6a
ptks
rtk
rtks
ryk
sca
sixteen
sorted
sorter
stk
turned
tyk
Tagcloud (Difference)
?
amplify
blk
bpk
cdnas
cmet
degenerate
eck
f1
fer
fes
fgr
flk
fyn
hck
kit
lacked
lin
ly6a
ptks
rtk
rtks
ryk
sca
sixteen
sorted
sorter
stk
turned
tyk
Tagcloud (Intersection)
?