TEK and DOK4

Number of citations of the paper that reports this interaction (PMID 11470823)
30

Data Source:
HPRD (in vivo)

		TEK	DOK4
Gene Name		TEK tyrosine kinase, endothelial	docking protein 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Extracellular Region Actin Filament Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cell-cell Junction Focal Adhesion Basal Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Activity Protein Binding ATP Binding Growth Factor Binding	Receptor Signaling Protein Activity Insulin Receptor Binding Protein Binding
	Biological Process	Angiogenesis Response To Hypoxia Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Sprouting Angiogenesis Positive Regulation Of Cytokine Secretion Involved In Immune Response Cell-matrix Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Heart Development Blood Coagulation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Single Organismal Cell-cell Adhesion Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Organ Regeneration Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Peptidyl-serine Phosphorylation Substrate Adhesion-dependent Cell Spreading Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Response To Peptide Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Estrogen Positive Regulation Of Angiogenesis Protein Autophosphorylation Tie Signaling Pathway Negative Regulation Of Inflammatory Response Leukocyte Migration Protein Oligomerization Response To CAMP Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Definitive Hemopoiesis Heart Trabecula Formation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Actin Cytoskeleton Reorganization Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development
Pathways		Tie2 Signaling Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ANGPT1 ANGPT2 ANGPT4 ANGPTL1 APP DOK2 DOK4 GRB14 GRB2 GRB7 IKBKG PIK3R1 PTPN11 PTPRB SHC1 SOCS1 STAT5A STAT5B TIE1 TNIP2	11 interactors: CRK EGFR ERBB2 FYN IGF1R INSR OPRM1 RASA1 RET SRC TEK
Entrez ID		7010	55715
HPRD ID		02571	16316
Ensembl ID		ENSG00000120156	ENSG00000125170
Uniprot IDs		Q02763 Q59HG2	H3BQ19 Q8TEW6
PDB IDs		1FVR 2GY5 2GY7 2OO8 2OSC 2P4I 2WQB 3BEA 3L8P 4K0V
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Body Fluid Levels Enzyme Linked Receptor Protein Signaling Pathway Leukocyte Migration Blood Coagulation Hemostasis Immune System Process Signal Transduction Wound Healing Signaling Cell Communication Cell Surface Receptor Signaling Pathway Response To Wounding Cellular Response To Stimulus Cell Migration Regulation Of Immune Response Response To Stimulus Cell Motility Locomotion Response To Stress Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Growth Hormone Stimulus Cellular Response To Peptide Movement Of Cell Or Subcellular Component Positive Regulation Of Signal Transduction Regulation Of Immune System Process Regulation Of Signal Transduction Response To Growth Hormone Regulation Of Innate Immune Response Intracellular Signal Transduction Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signaling Regulation Of Kinase Activity Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Angiogenesis ERBB Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Phosphorylation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Defense Response Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Development Of Secondary Male Sexual Characteristics JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Protein Autophosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Protein Kinase B Signaling Regulation Of Signaling Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Positive Regulation Of Phosphorylation Peptidyl-amino Acid Modification Regulation Of Catalytic Activity Peptidyl-tyrosine Autophosphorylation Regulation Of Protein Kinase B Signaling Response To Growth Factor Response To Organic Substance Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cellular Response To Organic Substance Intracellular Signal Transduction Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Component Organization Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Kinase Activity Regulation Of ERK1 And ERK2 Cascade Response To Peptide Hormone Immune System Process Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Response To Peptide Positive Regulation Of Kinase Activity Neurotrophin Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Positive Regulation Of Catalytic Activity Response To Hormone Neuron Development Generation Of Neurons Axonogenesis Anatomical Structure Morphogenesis
Tagcloud ?		amplify blk bpk cdnas cmet degenerate eck f1 fer fes fgr flk fyn hck kit lacked lin ly6a ptks rtk rtks ryk sca sixteen sorted sorter stk turned tyk	17p12 19q13 4q27 5p13 7q36 9q34 amacr bcl3 ccl17 ccl22 cd30 cdk9 chemoresponsive cnas cx3cl1 encompassed id4 il10 il21 lcn2 nell1 nonrandom ppargc1a ptges recurring reed spry1 sternberg txnip
Tagcloud (Difference) ?		amplify blk bpk cdnas cmet degenerate eck f1 fer fes fgr flk fyn hck kit lacked lin ly6a ptks rtk rtks ryk sca sixteen sorted sorter stk turned tyk	17p12 19q13 4q27 5p13 7q36 9q34 amacr bcl3 ccl17 ccl22 cd30 cdk9 chemoresponsive cnas cx3cl1 encompassed id4 il10 il21 lcn2 nell1 nonrandom ppargc1a ptges recurring reed spry1 sternberg txnip
Tagcloud (Intersection) ?