TEK and PTPRB

Number of citations of the paper that reports this interaction (PMID 10557082)
26

Data Source:
HPRD (in vivo)

		TEK	PTPRB
Gene Name		TEK tyrosine kinase, endothelial	protein tyrosine phosphatase, receptor type, B
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Extracellular Region Actin Filament Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cell-cell Junction Focal Adhesion Basal Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Membrane Raft Perinuclear Region Of Cytoplasm	Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Activity Protein Binding ATP Binding Growth Factor Binding	Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Angiogenesis Response To Hypoxia Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Sprouting Angiogenesis Positive Regulation Of Cytokine Secretion Involved In Immune Response Cell-matrix Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Heart Development Blood Coagulation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Single Organismal Cell-cell Adhesion Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Organ Regeneration Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Peptidyl-serine Phosphorylation Substrate Adhesion-dependent Cell Spreading Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Response To Peptide Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Estrogen Positive Regulation Of Angiogenesis Protein Autophosphorylation Tie Signaling Pathway Negative Regulation Of Inflammatory Response Leukocyte Migration Protein Oligomerization Response To CAMP Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Definitive Hemopoiesis Heart Trabecula Formation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Actin Cytoskeleton Reorganization Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process	Angiogenesis Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		Tie2 Signaling Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ANGPT1 ANGPT2 ANGPT4 ANGPTL1 APP DOK2 DOK4 GRB14 GRB2 GRB7 IKBKG PIK3R1 PTPN11 PTPRB SHC1 SOCS1 STAT5A STAT5B TIE1 TNIP2	10 interactors: CDH5 CNTN1 CNTNAP1 F11R GHR MAGI3 MET NRCAM TEK TNC
Entrez ID		7010	5787
HPRD ID		02571	01474
Ensembl ID		ENSG00000120156	ENSG00000127329
Uniprot IDs		Q02763 Q59HG2	B7ZKS8 F5H3G6 P23467 Q86VA4
PDB IDs		1FVR 2GY5 2GY7 2OO8 2OSC 2P4I 2WQB 3BEA 3L8P 4K0V	2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Body Fluid Levels Enzyme Linked Receptor Protein Signaling Pathway Leukocyte Migration Blood Coagulation Hemostasis Immune System Process Signal Transduction Wound Healing Signaling Cell Communication Cell Surface Receptor Signaling Pathway Response To Wounding Cellular Response To Stimulus Cell Migration Regulation Of Immune Response Response To Stimulus Cell Motility Locomotion Response To Stress Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Growth Hormone Stimulus Cellular Response To Peptide Movement Of Cell Or Subcellular Component Positive Regulation Of Signal Transduction Regulation Of Immune System Process Regulation Of Signal Transduction Response To Growth Hormone Regulation Of Innate Immune Response Intracellular Signal Transduction Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signaling Regulation Of Kinase Activity Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Angiogenesis ERBB Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Phosphorylation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Defense Response Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Development Of Secondary Male Sexual Characteristics JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Cell Adhesion Signaling Cell Communication Cell Development Axon Development Locomotion Neuronal Action Potential Propagation Cell Morphogenesis Involved In Differentiation Neuron Projection Development Movement Of Cell Or Subcellular Component Axon Guidance Mesenchymal-epithelial Cell Signaling Enzyme Linked Receptor Protein Signaling Pathway Neuron Development Positive Regulation Of MAPK Cascade Response To Stimulus Positive Regulation Of Kinase Activity Cell Morphogenesis Axonogenesis Neuron Differentiation Cell Projection Organization Positive Regulation Of Transferase Activity Cell Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cellular Response To Stimulus Cell-cell Junction Organization Positive Regulation Of MAP Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Anatomical Structure Development Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Establishment Or Maintenance Of Cell Polarity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Signal Transduction Endothelial Cell Development Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Generation Of Neurons Developmental Process Positive Regulation Of Intracellular Signal Transduction Transmission Of Nerve Impulse
Tagcloud ?		amplify blk bpk cdnas cmet degenerate eck f1 fer fes fgr flk fyn hck kit lacked lin ly6a ptks rtk rtks ryk sca sixteen sorted sorter stk turned tyk	accumulative acknowledged astrocytoma chi3l1 chr1 chr22 clustering crocc daughter discover ecm exome gbm hereditary lymphatic multiforme narrow pilocytic players pms2 pontine predisposition proximity q12 siblings snvs striking synonymous underline
Tagcloud (Difference) ?		amplify blk bpk cdnas cmet degenerate eck f1 fer fes fgr flk fyn hck kit lacked lin ly6a ptks rtk rtks ryk sca sixteen sorted sorter stk turned tyk	accumulative acknowledged astrocytoma chi3l1 chr1 chr22 clustering crocc daughter discover ecm exome gbm hereditary lymphatic multiforme narrow pilocytic players pms2 pontine predisposition proximity q12 siblings snvs striking synonymous underline
Tagcloud (Intersection) ?