TEK and PTPRB

Number of citations of the paper that reports this interaction (PubMedID 10557082)
0

Data Source:
HPRD (in vivo)

		TEK	PTPRB
Description		TEK receptor tyrosine kinase	protein tyrosine phosphatase receptor type B
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GO Annotations	Cellular Component	Stress Fiber Extracellular Region Cytoplasm Centrosome Cytoskeleton Actin Filament Plasma Membrane Microvillus Cell-cell Junction Focal Adhesion Basal Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Ciliary Basal Body Receptor Complex Membrane Raft Anchoring Junction	Plasma Membrane Membrane Specific Granule Membrane Receptor Complex Tertiary Granule Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Signaling Receptor Activity Identical Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Cadherin Binding
	Biological Process	Angiogenesis Endothelial Cell Proliferation Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Heart Development Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Hemopoiesis Regulation Of Cell Migration Cell-substrate Adhesion Regulation Of Establishment Or Maintenance Of Cell Polarity Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Positive Regulation Of MAPK Cascade Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Tie Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Definitive Hemopoiesis Heart Trabecula Formation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Glomerulus Vasculature Development Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process	Angiogenesis Osteoblast Differentiation Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Glial Cell Migration Dephosphorylation Developmental Process Negative Regulation Of Osteoblast Differentiation
Pathways		Tie2 Signaling Tie2 Signaling RAF/MAP kinase cascade	Neutrophil degranulation
Drugs		Ampicillin Vandetanib N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE Regorafenib Ponatinib Tivozanib Fostamatinib Ripretinib	{4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID (4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID {4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID (4-ETHYLPHENYL)SULFAMIC ACID Razuprotafib
Diseases		Venous malformations, including: Sporadic venous malformation; Cutaneomucosal venous malformation; Glomuvenous malformation
GWAS		Adult asthma ( 27611488) Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Asthma ( 27611488) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Cognitive decline (age-related) ( 28078323) Coronary artery disease ( 29212778) Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821)	Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		26 interacting genes: ANGPT1 ANGPT2 ANGPT4 ANGPTL1 APP CAV1 DOK2 DOK4 DUSP18 GRB14 GRB2 GRB7 IKBKG ILKAP PIK3R1 PTPN11 PTPRB PTPRR SHC1 SHC4 SOCS1 STAT5A STAT5B STYX TIE1 TNIP2	11 interacting genes: CDH5 CNTN1 CNTNAP1 EGFR F11R GHR MAGI3 MET NRCAM TEK TNC
Entrez ID		7010	5787
HPRD ID		02571	01474
Ensembl ID		ENSG00000120156	ENSG00000127329
Uniprot IDs		Q02763 Q59HG2	F8VU56 P23467 Q86VA4
PDB IDs		1FVR 2GY5 2GY7 2OO8 2OSC 2P4I 2WQB 3BEA 3L8P 4K0V 4X3J 5MYA 5MYB 5UTK 6MWE 7E72	2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X 8JBN 8JBY
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Receptor Tyrosine Kinase Binding Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin Receptor Binding Negative Regulation Of Developmental Process Neurotrophin TRKA Receptor Binding Positive Regulation Of Cell Activation ERBB Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Cell Adhesion Regulation Of Body Fluid Levels Positive Regulation Of Multicellular Organismal Process Regulation Of Innate Immune Response Angiogenesis Regulation Of MAPK Cascade Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Activation Natural Killer Cell Mediated Immunity Phosphotyrosine Residue Binding Regulation Of Cell Migration Positive Regulation Of Immune System Process Regulation Of Cell Motility Regulation Of Locomotion Anatomical Structure Formation Involved In Morphogenesis Insulin-like Growth Factor Receptor Binding Phosphoprotein Phosphatase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of T Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of ERK1 And ERK2 Cascade Protein Kinase Binding Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Regulation Of Insulin Receptor Signaling Pathway Leukocyte Mediated Cytotoxicity Regulation Of Cellular Response To Insulin Stimulus Regulation Of Signal Transduction Negative Regulation Of Cell Adhesion Response To Growth Factor Regulation Of Immune Response Growth Hormone Receptor Signaling Pathway Development Of Secondary Female Sexual Characteristics	Cell Adhesion Protein Phosphatase Binding Regulation Of Cellular Component Organization Cell-cell Junction Anchoring Junction Cell Junction Cell-cell Adhesion Bicellular Tight Junction Cell-cell Adhesion Mediator Activity Regulation Of Endothelial Cell Differentiation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Cell Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Mechanical Stimulus Receptor Complex Cell Junction Organization Basal Plasma Membrane Developmental Process Animal Organ Development Membrane Anatomical Structure Morphogenesis Synapse Organization Cell Junction Assembly Glutamatergic Synapse Action Potential Propagation Neuronal Action Potential Propagation Regulation Of Rho Protein Signal Transduction Endothelial Cell Morphogenesis Regulation Of Developmental Process Cell Surface Cadherin Binding Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activator Activity Response To Estradiol Morphogenesis Of An Epithelium Plasma Membrane Regulation Of Establishment Of Endothelial Barrier Cell-cell Junction Assembly Protein Localization To Cell-cell Junction Positive Regulation Of Homotypic Cell-cell Adhesion Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Developmental Process Tissue Morphogenesis Regulation Of Establishment Or Maintenance Of Cell Polarity Anatomical Structure Formation Involved In Morphogenesis
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