TEK and SHC4

Number of citations of the paper that reports this interaction (PubMedID 33495401)
63

Data Source:
BioGRID (pull down, enzymatic study)

		TEK	SHC4
Description		TEK receptor tyrosine kinase	SHC adaptor protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Extracellular Region Cytoplasm Centrosome Cytoskeleton Actin Filament Plasma Membrane Microvillus Cell-cell Junction Focal Adhesion Basal Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Ciliary Basal Body Receptor Complex Membrane Raft Anchoring Junction	Plasma Membrane Membrane Synapse Postsynaptic Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Signaling Receptor Activity Identical Protein Binding	Protein Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding
	Biological Process	Angiogenesis Endothelial Cell Proliferation Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Heart Development Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Hemopoiesis Regulation Of Cell Migration Cell-substrate Adhesion Regulation Of Establishment Or Maintenance Of Cell Polarity Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Positive Regulation Of MAPK Cascade Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Tie Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Definitive Hemopoiesis Heart Trabecula Formation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Glomerulus Vasculature Development Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process	Apoptotic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Intracellular Signal Transduction Stem Cell Differentiation
Pathways		Tie2 Signaling Tie2 Signaling RAF/MAP kinase cascade
Drugs		Ampicillin Vandetanib N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE Regorafenib Ponatinib Tivozanib Fostamatinib Ripretinib
Diseases		Venous malformations, including: Sporadic venous malformation; Cutaneomucosal venous malformation; Glomuvenous malformation
GWAS		Adult asthma ( 27611488) Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Asthma ( 27611488) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Cognitive decline (age-related) ( 28078323) Coronary artery disease ( 29212778) Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821)	Cadmium levels ( 26025379) Eating disorders ( 22911880) Iris color (b* coordinate) ( 30895295) Major depressive disorder ( 21621269 29187746) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Skin aging measurement ( 31522824)
Interacting Genes		26 interacting genes: ANGPT1 ANGPT2 ANGPT4 ANGPTL1 APP CAV1 DOK2 DOK4 DUSP18 GRB14 GRB2 GRB7 IKBKG ILKAP PIK3R1 PTPN11 PTPRB PTPRR SHC1 SHC4 SOCS1 STAT5A STAT5B STYX TIE1 TNIP2	10 interacting genes: AR EGFR ERBB2 ERBB3 ERBB4 GRB2 KIT MET RET TEK
Entrez ID		7010	399694
HPRD ID		02571	15289
Ensembl ID		ENSG00000120156	ENSG00000185634
Uniprot IDs		Q02763 Q59HG2	F5H5M1 Q6S5L8
PDB IDs		1FVR 2GY5 2GY7 2OO8 2OSC 2P4I 2WQB 3BEA 3L8P 4K0V 4X3J 5MYA 5MYB 5UTK 6MWE 7E72
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Receptor Tyrosine Kinase Binding Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin Receptor Binding Negative Regulation Of Developmental Process Neurotrophin TRKA Receptor Binding Positive Regulation Of Cell Activation ERBB Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Cell Adhesion Regulation Of Body Fluid Levels Positive Regulation Of Multicellular Organismal Process Regulation Of Innate Immune Response Angiogenesis Regulation Of MAPK Cascade Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Activation Natural Killer Cell Mediated Immunity Phosphotyrosine Residue Binding Regulation Of Cell Migration Positive Regulation Of Immune System Process Regulation Of Cell Motility Regulation Of Locomotion Anatomical Structure Formation Involved In Morphogenesis Insulin-like Growth Factor Receptor Binding Phosphoprotein Phosphatase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of T Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of ERK1 And ERK2 Cascade Protein Kinase Binding Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Regulation Of Insulin Receptor Signaling Pathway Leukocyte Mediated Cytotoxicity Regulation Of Cellular Response To Insulin Stimulus Regulation Of Signal Transduction Negative Regulation Of Cell Adhesion Response To Growth Factor Regulation Of Immune Response Growth Hormone Receptor Signaling Pathway Development Of Secondary Female Sexual Characteristics	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Basal Plasma Membrane Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Protein Kinase Activity Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction ERBB Signaling Pathway ERBB2 Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Animal Organ Development Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Neuron Differentiation Cellular Developmental Process Regulation Of Epithelial Cell Proliferation Regulation Of Signal Transduction ATP Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Population Proliferation Basolateral Plasma Membrane Schwann Cell Development Cell Differentiation Positive Regulation Of Signal Transduction ERBB3:ERBB2 Complex Nucleotide Binding Transferase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Multicellular Organismal Process Plasma Membrane Tissue Morphogenesis Growth Factor Binding Epithelial Cell Proliferation Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Apoptotic Process Intracellular Signaling Cassette
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