PIP4K2A and GSTK1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PIP4K2A	GSTK1
Description		phosphatidylinositol-5-phosphate 4-kinase type 2 alpha	glutathione S-transferase kappa 1
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm Lysosome Autophagosome Cytosol Plasma Membrane Membrane Cell Projection	Cytoplasm Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Transferase Activity Protein Homodimerization Activity Phosphatidylinositol Kinase Activity	Glutathione Transferase Activity Glutathione Peroxidase Activity Protein Binding Oxidoreductase Activity Transferase Activity
	Biological Process	Lipid Metabolic Process Regulation Of Autophagy Megakaryocyte Development Phosphatidylinositol Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Autophagosome-lysosome Fusion Vesicle-mediated Cholesterol Transport 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly	Glutathione Metabolic Process Epithelial Cell Differentiation Cellular Oxidant Detoxification
Pathways		Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus	Glutathione conjugation Peroxisomal protein import Peroxisomal protein import
Drugs			Glutathione GLUTATHIONE SULFINATE
Diseases
GWAS		Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 29348612) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) B-cell acute lymphoblastic leukaemia ( 31767839) Height ( 31562340) Lymphocyte percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Positive urgency ( 30718321) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		6 interacting genes: BTK GSTK1 MEIS3 RAC1 RPS6KB1 TEC	7 interacting genes: CCNDBP1 FAM9B GRB2 KRT27 PEX5 PIP4K2A PRPF19
Entrez ID		5305	373156
HPRD ID		11931	13613
Ensembl ID		ENSG00000150867	ENSG00000197448
Uniprot IDs		P48426	Q6FII1 Q9Y2Q3
PDB IDs		2YBX 6OSP 6UX9 6YM3 6YM4 6YM5 7N6Z 7N71 7N7J 7N7K 7N7L 7N7M 7N7N 7N7O 8C8C	1YZX 3RPN 3RPP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Type I Hypersensitivity Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Protein Phosphorylation B Cell Receptor Signaling Pathway T Cell Receptor Signaling Pathway Developmental Process Phosphorylation Protein Kinase Activity B Cell Affinity Maturation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Protein Tyrosine Kinase Activity Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Positive Regulation Of Synoviocyte Proliferation Antigen Receptor-mediated Signaling Pathway Cellular Response To Molecule Of Fungal Origin Kinase Activity Negative Regulation Of TORC2 Signaling Histamine Secretion By Mast Cell Response To Molecule Of Fungal Origin Regulation Of Ovarian Follicle Development Erythrocyte Enucleation Cellular Developmental Process Transferase Activity Intracellular Signal Transduction Histamine Secretion Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of CGAS/STING Signaling Pathway Nucleotide Binding Positive Regulation Of Protein-containing Complex Assembly Response To Lipid Homeostasis Of Number Of Cells Kinocilium G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Auditory Receptor Cell Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Hepatocyte Growth Factor Receptor Signaling Pathway Engulfment Of Apoptotic Cell
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