PIP4K2A and BTK

Number of citations of the paper that reports this interaction (PMID 14614850)
4

Data Source:
HPRD (in vitro, in vivo)

		PIP4K2A	BTK
Gene Name		phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	Bruton agammaglobulinemia tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleus Cytosol Plasma Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Mast Cell Granule Intracellular Membrane-bounded Organelle Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Megakaryocyte Development Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation	Toll-like Receptor Signaling Pathway Adaptive Immune Response Histamine Secretion By Mast Cell Regulation Of B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of B Cell Apoptotic Process Transcription, DNA-templated Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Mesoderm Development Calcium-mediated Signaling Cell Differentiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway B Cell Activation Regulation Of Cell Proliferation Innate Immune Response Positive Regulation Of B Cell Differentiation Cell Maturation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Molecule Of Fungal Origin Apoptotic Signaling Pathway
Pathways		Synthesis of PIPs at the plasma membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism	Signaling by the B Cell Receptor (BCR) DAP12 interactions Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MyD88:Mal cascade initiated on plasma membrane FCERI mediated Ca+2 mobilization Fcgamma receptor (FCGR) dependent phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Regulation of actin dynamics for phagocytic cup formation Adaptive Immune System Innate Immune System
Drugs			Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: BTK GSTK1 RAC1 TEC	64 interactors: ABL1 APP ARHGAP17 ARID3A ARRB1 BCL2L11 BLNK BMX CAV1 CBL CD19 CMTM3 DAPP1 EWSR1 FAS FASLG FYN GNA12 GNAQ GNG2 GTF2I HCK IBTK IRAK1 ITK JAK1 KHDRBS1 KIT LYN MYD88 PIK3AP1 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PLAU PLCG1 PLCG2 PRKCA PRKCB PRKCE PRKCQ PRKCZ PRKD1 RELA RPS6KB1 RPS6KB2 SH2B2 SH3BP5 STAT5A SYK TEC TIRAP TLR4 TLR6 TLR8 TLR9 TNFRSF10A TP53 VAV1 WAS WASF2
Entrez ID		5305	695
HPRD ID		11931	02248
Ensembl ID		ENSG00000150867	ENSG00000010671
Uniprot IDs		P48426	Q06187 Q5JY90
PDB IDs		2YBX	1AWW 1AWX 1B55 1BTK 1BWN 1K2P 1QLY 2GE9 2Z0P 3GEN 3K54 3OCS 3OCT 3P08 3PIX 3PIY 3PIZ 3PJ1 3PJ2 3PJ3
Enriched GO Terms of Interacting Partners?		Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Tissue Development Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Inner Ear Morphogenesis Innate Immune Response Ear Morphogenesis Regulation Of B Cell Cytokine Production Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Mesoderm Development Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Cellular Response To Molecule Of Fungal Origin Inner Ear Development Response To Reactive Oxygen Species Pallium Development Cell Differentiation Protein Autophosphorylation Engulfment Of Apoptotic Cell Ear Development Response To Molecule Of Fungal Origin Vestibular Reflex Mast Cell Chemotaxis Immune Response Regulation Of Immune System Process Defense Response Adaptive Immune Response Peptidyl-tyrosine Phosphorylation Telencephalon Development Regulation Of Apoptotic Process Positive Regulation Of Cell Activation Regulation Of Cell Death Embryonic Organ Morphogenesis Tangential Migration From The Subventricular Zone To The Olfactory Bulb Apoptotic Signaling Pathway Olfactory Bulb Interneuron Development Axon Guidance Regulation Of Lymphocyte Activation Regulation Of Hydrogen Peroxide Metabolic Process Cell Development	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Immune System Process Signaling Cell Surface Receptor Signaling Pathway Cell Communication Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune Response Cellular Response To Stimulus Blood Coagulation Hemostasis Cell Activation Response To Stress Defense Response Positive Regulation Of Signal Transduction Regulation Of Body Fluid Levels Wound Healing Regulation Of Signal Transduction Response To Wounding Positive Regulation Of Intracellular Signal Transduction Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Stimulus Fc Receptor Signaling Pathway Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Platelet Activation Regulation Of Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Response To Organic Substance Phosphorylation Cellular Response To Organic Substance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Metabolic Process Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cytokine Biosynthetic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Leukocyte Activation Protein Autophosphorylation
Tagcloud ?		accompanied amplification bearing cancers dramatic encoding express homozygous importantly kinases knocking lethality littermates phosphate phosphatidylinositol plastic preventing ros senescence subset synthetic tp53 treating viable xenografts	adhesion allergic appear asthma compares contrasts csf degranulation describes emerging eosinophil eosinophils exert gm granulocyte hematopoiesis heterodimer jak lyn macrophage paramount propagates raf segregation seminal shp stat syk transduction
Tagcloud (Difference) ?		accompanied amplification bearing cancers dramatic encoding express homozygous importantly kinases knocking lethality littermates phosphate phosphatidylinositol plastic preventing ros senescence subset synthetic tp53 treating viable xenografts	adhesion allergic appear asthma compares contrasts csf degranulation describes emerging eosinophil eosinophils exert gm granulocyte hematopoiesis heterodimer jak lyn macrophage paramount propagates raf segregation seminal shp stat syk transduction
Tagcloud (Intersection) ?