PIP4K2A and TEC

Number of citations of the paper that reports this interaction (PMID 14614854)
33

Data Source:
HPRD (in vivo, in vitro)

		PIP4K2A	TEC
Gene Name		phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	tec protein tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleus Cytosol Plasma Membrane	Cytosol Cytoskeleton Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity	Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Lipid Binding Metal Ion Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Megakaryocyte Development Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation	Adaptive Immune Response Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Proliferation Tissue Regeneration Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		Synthesis of PIPs at the plasma membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism	Signaling by SCF-KIT Signaling by Interleukins Fc epsilon receptor (FCERI) signaling Cytokine Signaling in Immune system FCERI mediated Ca+2 mobilization Interleukin-3, 5 and GM-CSF signaling Innate Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Crohn's disease ( 23128233)
Protein-Protein Interactions		4 interactors: BTK GSTK1 RAC1 TEC	30 interactors: ARHGEF12 BMX BTK DOK1 ERBB2 FASLG GNA12 IKBKG JAK1 JAK2 KIT LYN PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PTPN18 PTPN21 RHOA SHC1 SOCS1 STAP1 TP53 VAV1 WAS
Entrez ID		5305	7006
HPRD ID		11931	02786
Ensembl ID		ENSG00000150867	ENSG00000135605
Uniprot IDs		P48426	P42680
PDB IDs		2YBX	2LUL
Enriched GO Terms of Interacting Partners?		Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Tissue Development Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Inner Ear Morphogenesis Innate Immune Response Ear Morphogenesis Regulation Of B Cell Cytokine Production Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Mesoderm Development Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Cellular Response To Molecule Of Fungal Origin Inner Ear Development Response To Reactive Oxygen Species Pallium Development Cell Differentiation Protein Autophosphorylation Engulfment Of Apoptotic Cell Ear Development Response To Molecule Of Fungal Origin Vestibular Reflex Mast Cell Chemotaxis Immune Response Regulation Of Immune System Process Defense Response Adaptive Immune Response Peptidyl-tyrosine Phosphorylation Telencephalon Development Regulation Of Apoptotic Process Positive Regulation Of Cell Activation Regulation Of Cell Death Embryonic Organ Morphogenesis Tangential Migration From The Subventricular Zone To The Olfactory Bulb Apoptotic Signaling Pathway Olfactory Bulb Interneuron Development Axon Guidance Regulation Of Lymphocyte Activation Regulation Of Hydrogen Peroxide Metabolic Process Cell Development	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Innate Immune Response Fc Receptor Signaling Pathway Immune Response Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Immune Response Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Signal Transduction Wound Healing Immune Response-regulating Signaling Pathway Response To Organic Substance Signaling Defense Response Response To Wounding Cell Communication Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Organic Substance Regulation Of Immune System Process Cell Activation Regulation Of Signaling Regulation Of Catalytic Activity Cellular Response To Stimulus Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Response To Growth Factor Cell Differentiation Cellular Response To Peptide Hormone Stimulus Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Cellular Response To Growth Hormone Stimulus Movement Of Cell Or Subcellular Component Phagocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Phosphorylation
Tagcloud ?		accompanied amplification bearing cancers dramatic encoding express homozygous importantly kinases knocking lethality littermates phosphate phosphatidylinositol plastic preventing ros senescence subset synthetic tp53 treating viable xenografts
Tagcloud (Difference) ?		accompanied amplification bearing cancers dramatic encoding express homozygous importantly kinases knocking lethality littermates phosphate phosphatidylinositol plastic preventing ros senescence subset synthetic tp53 treating viable xenografts
Tagcloud (Intersection) ?