SLC4A1 and SLC4A1AP

Number of citations of the paper that reports this interaction (PMID 11934690)
14

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		SLC4A1	SLC4A1AP
Gene Name		solute carrier family 4 (anion exchanger), member 1 (Diego blood group)	solute carrier family 4 (anion exchanger), member 1, adaptor protein
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Z Disc Cortical Cytoskeleton Extracellular Vesicular Exosome Blood Microparticle	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Actin Binding Inorganic Anion Exchanger Activity Protein Binding Protein C-terminus Binding Anion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Anion:anion Antiporter Activity Ankyrin Binding Protein Homodimerization Activity Protein Anchor	Protein Binding
	Biological Process	Ion Transport Anion Transport Chloride Transport Cellular Ion Homeostasis Bicarbonate Transport Small Molecule Metabolic Process Regulation Of Intracellular PH Transmembrane Transport Chloride Transmembrane Transport
Pathways		O2/CO2 exchange in erythrocytes Erythrocytes take up carbon dioxide and release oxygen Transport of inorganic cations/anions and amino acids/oligopeptides Erythrocytes take up oxygen and release carbon dioxide SLC-mediated transmembrane transport Bicarbonate transporters
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Alzheimer's disease ( 22159054) Breast size ( 22747683)
Protein-Protein Interactions		13 interactors: ACTC1 ANK1 BLOC1S6 CA2 CA4 CANX CDKN2A EPB41 EPB42 LYN RHAG SLC4A1AP SYK	5 interactors: APP CSNK2A1 SLC4A1 SRPK1 TCF4
Entrez ID		6521	22950
HPRD ID		00175	04038
Ensembl ID		ENSG00000004939	ENSG00000163798
Uniprot IDs		P02730	Q9BWU0
PDB IDs		1BH7 1BNX 1BTQ 1BTR 1BTS 1BTT 1BZK 1HYN 2BTA 2BTB 3BTB	4H87
Enriched GO Terms of Interacting Partners?		Erythrocyte Differentiation Erythrocyte Homeostasis Secretion Bicarbonate Transport Myeloid Cell Homeostasis Developmental Process Erythrocyte Development Secretion By Cell Homeostasis Of Number Of Cells Myeloid Cell Differentiation Ammonium Transport Hemopoiesis Anion Transport Immune System Development Exocytosis Organ Development System Development Iron Ion Homeostasis Positive Regulation Of Bone Resorption Regulation Of Platelet Aggregation Protein Secretion Negative Regulation Of B Cell Proliferation Regulation Of Lymphocyte Activation Transition Metal Ion Homeostasis Multicellular Organismal Development Regulation Of Cell Activation Regulation Of Mast Cell Degranulation Anatomical Structure Development Production Of Molecular Mediator Involved In Inflammatory Response Regulation Of Platelet Activation Positive Regulation Of Tissue Remodeling Ion Transport Positive Regulation Of Leukocyte Apoptotic Process Cell Development Ion Homeostasis Regulation Of Mast Cell Activation Regulation Of Bone Resorption Negative Regulation Of B Cell Activation Regulation Of Regulated Secretory Pathway B Cell Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Adhesion Mediated By Integrin One-carbon Metabolic Process Regulation Of Bone Remodeling Monovalent Inorganic Cation Transport Inorganic Anion Transport Regulation Of Immune System Process Immune System Process Homeostatic Process Regulation Of T Cell Activation	Cell Development Regulation Of Growth Regulation Of Protein Binding Synaptic Growth At Neuromuscular Junction Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Chemical Homeostasis Regulation Of Cell Cycle Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Collateral Sprouting In Absence Of Injury Maintenance Of DNA Repeat Elements Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Endopeptidase Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Peptidase Activity Wnt Signaling Pathway Axon Choice Point Recognition Embryonic Genitalia Morphogenesis Regulation Of Developmental Growth RNA Metabolic Process Myoblast Fate Commitment Protein Phosphorylation Regulation Of Wnt Signaling Pathway Reproductive Process Homeostatic Process Cell Differentiation Neuron Remodeling Sperm Chromatin Condensation Secretory Granule Localization Gene Expression Negative Regulation Of Proteolysis Hindgut Morphogenesis Negative Regulation Of Protein Processing Insulin Metabolic Process Generation Of Neurons Regulation Of Endopeptidase Activity Axon Guidance Hindgut Development Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Export From Nucleus
Tagcloud ?		acidosis ae1 anion bicarbonate calnexin cotranslationally destination exchanger folded folding glycoproteins glycosylated hereditary interfere kae1 misfolded monitors ovalocytosis properly retrotranslocation slc26 southeast spherocytosis summarizes traffic trafficking transporters ubiquitinylation
Tagcloud (Difference) ?		acidosis ae1 anion bicarbonate calnexin cotranslationally destination exchanger folded folding glycoproteins glycosylated hereditary interfere kae1 misfolded monitors ovalocytosis properly retrotranslocation slc26 southeast spherocytosis summarizes traffic trafficking transporters ubiquitinylation
Tagcloud (Intersection) ?