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SLC4A1
Description
solute carrier family 4 member 1 (Diego blood group)
Image
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Membrane
Basolateral Plasma Membrane
Z Disc
Cortical Cytoskeleton
Extracellular Exosome
Blood Microparticle
Ankyrin-1 Complex
Molecular Function
Solute:inorganic Anion Antiporter Activity
Protein Binding
Cytoskeletal Protein Binding
Monoatomic Anion Transmembrane Transporter Activity
Bicarbonate Transmembrane Transporter Activity
Chloride Transmembrane Transporter Activity
Antiporter Activity
Hemoglobin Binding
Ankyrin Binding
Protein Homodimerization Activity
Protein-membrane Adaptor Activity
Chloride:bicarbonate Antiporter Activity
Biological Process
Monoatomic Ion Transport
Monoatomic Anion Transport
Chloride Transport
Intracellular Monoatomic Ion Homeostasis
Blood Coagulation
Bicarbonate Transport
Plasma Membrane Phospholipid Scrambling
Negative Regulation Of Urine Volume
PH Elevation
Erythrocyte Development
Regulation Of Intracellular PH
Transmembrane Transport
Protein Localization To Plasma Membrane
Chloride Transmembrane Transport
Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate
Pathways
Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Bicarbonate transporters
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)
Drugs
Diseases
Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP)
Distal renal tubular acidosis (RTA type 1)
Hereditary spherocytosis (SPH)
Hereditary elliptocytosis (HE)
GWAS
Appendicular lean mass (
33097823
)
Bipolar disorder (
31043756
)
Hemoglobin (
32888494
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
hemolysis of donated blood (osmotic) (
34014839
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Immature fraction of reticulocytes (
27863252
32888494
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
29403010
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Obesity-related traits (
23251661
)
Red cell distribution width (
27863252
28957414
32888494
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Urate levels (
31578528
)
Novel Interacting Genes
1 novel interacting genes:
ZBTB14
Interacting Genes
17 interacting genes:
ACTC1
ADAM33
ANK1
BLOC1S6
BMP10
CA2
CA4
CANX
CDKN2A
CFHR5
EPB41
EPB42
LYN
RHAG
SLC4A1AP
SYK
TMEM60
Entrez ID
6521
HPRD ID
00175
Ensembl ID
ENSG00000004939
Uniprot IDs
P02730
PDB IDs
1BH7
1BNX
1BTQ
1BTR
1BTS
1BTT
1BZK
1HYN
2BTA
2BTB
3BTB
4KY9
4YZF
7TVZ
7TW0
7TW1
7TW2
7TW3
7TW5
7TW6
7TY4
7TY6
7TY7
7TY8
7TYA
7UZ3
7UZU
7UZV
7V07
7V0K
7V0M
7V0T
7V0U
7V0Y
7V19
8CRQ
8CRR
8CRT
8CS9
8CSL
8CSV
8CSY
8CT3
8CTE
8T3R
8T3U
8T44
8T45
8T47
8T6U
8T6V
Enriched GO Terms of Interacting Partners
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Ankyrin-1 Complex
Secretion
Secretion By Cell
Spectrin-associated Cytoskeleton
Carbonate Dehydratase Activity
Carbon Dioxide Transport
Actomyosin Structure Organization
Structural Constituent Of Cytoskeleton
Bicarbonate Transport
Negative Regulation Of B Cell Proliferation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Stimulatory C-type Lectin Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Cellular Response To Lectin
Fc-epsilon Receptor Signaling Pathway
One-carbon Compound Transport
Regulation Of B Cell Activation
Multicellular Organismal-level Iron Ion Homeostasis
Spectrin Binding
Cortical Cytoskeleton
Positive Regulation Of Leukocyte Apoptotic Process
Regulation Of Platelet Aggregation
Regulation Of Mast Cell Degranulation
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Negative Regulation Of B Cell Activation
Negative Regulation Of Protein Serine/threonine Kinase Activity
Fc-gamma Receptor Signaling Pathway
Kidney Development
Phosphoprotein Binding
Protein-containing Complex
Ligase Inhibitor Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Methylammonium Transmembrane Transporter Activity
Interleukin-15 Receptor Binding
Positive Regulation Of Interleukin-3 Production
Bradykinin Biosynthetic Process
Circadian Sleep/wake Cycle
Exocytosis
Regulation Of Cell Adhesion Mediated By Integrin
Peptidyl-tyrosine Phosphorylation
Multicellular Organismal-level Homeostasis
B Cell Receptor Signaling Pathway
Regulation Of Platelet Activation
Cell Surface Pattern Recognition Receptor Signaling Pathway
Homeostatic Process
Chemical Homeostasis
Fc Receptor Signaling Pathway
Cardiac Muscle Tissue Morphogenesis
Basolateral Plasma Membrane
Positive Regulation Of Dipeptide Transmembrane Transport
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