SLC4A1 and CA4

Number of citations of the paper that reports this interaction (PMID 11994299)
34

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		SLC4A1	CA4
Gene Name		solute carrier family 4 (anion exchanger), member 1 (Diego blood group)	carbonic anhydrase IV
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Z Disc Cortical Cytoskeleton Extracellular Vesicular Exosome Blood Microparticle	Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Secretory Granule Membrane Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Sarcolemma Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Inorganic Anion Exchanger Activity Protein Binding Protein C-terminus Binding Anion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Anion:anion Antiporter Activity Ankyrin Binding Protein Homodimerization Activity Protein Anchor	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding
	Biological Process	Ion Transport Anion Transport Chloride Transport Cellular Ion Homeostasis Bicarbonate Transport Small Molecule Metabolic Process Regulation Of Intracellular PH Transmembrane Transport Chloride Transmembrane Transport	One-carbon Metabolic Process Bicarbonate Transport Response To Drug Small Molecule Metabolic Process Organ Development Response To Steroid Hormone
Pathways		O2/CO2 exchange in erythrocytes Erythrocytes take up carbon dioxide and release oxygen Transport of inorganic cations/anions and amino acids/oligopeptides Erythrocytes take up oxygen and release carbon dioxide SLC-mediated transmembrane transport Bicarbonate transporters	O2/CO2 exchange in erythrocytes Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide
Drugs			Methyclothiazide Topiramate Ethoxzolamide Bendroflumethiazide Benzthiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Chlorothiazide Zonisamide Hydrochlorothiazide Trichlormethiazide Dichlorphenamide Brinzolamide Ellagic Acid
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: ACTC1 ANK1 BLOC1S6 CA2 CA4 CANX CDKN2A EPB41 EPB42 LYN RHAG SLC4A1AP SYK	5 interactors: PIH1D1 PRDX2 SLC4A1 SLC4A3 SLC4A4
Entrez ID		6521	762
HPRD ID		00175	00261
Ensembl ID		ENSG00000004939	ENSG00000167434
Uniprot IDs		P02730	P22748 Q6FHI7
PDB IDs		1BH7 1BNX 1BTQ 1BTR 1BTS 1BTT 1BZK 1HYN 2BTA 2BTB 3BTB	1ZNC 3F7B 3F7U 3FW3
Enriched GO Terms of Interacting Partners?		Erythrocyte Differentiation Erythrocyte Homeostasis Secretion Bicarbonate Transport Myeloid Cell Homeostasis Developmental Process Erythrocyte Development Secretion By Cell Homeostasis Of Number Of Cells Myeloid Cell Differentiation Ammonium Transport Hemopoiesis Anion Transport Immune System Development Exocytosis Organ Development System Development Iron Ion Homeostasis Positive Regulation Of Bone Resorption Regulation Of Platelet Aggregation Protein Secretion Negative Regulation Of B Cell Proliferation Regulation Of Lymphocyte Activation Transition Metal Ion Homeostasis Multicellular Organismal Development Regulation Of Cell Activation Regulation Of Mast Cell Degranulation Anatomical Structure Development Production Of Molecular Mediator Involved In Inflammatory Response Regulation Of Platelet Activation Positive Regulation Of Tissue Remodeling Ion Transport Positive Regulation Of Leukocyte Apoptotic Process Cell Development Ion Homeostasis Regulation Of Mast Cell Activation Regulation Of Bone Resorption Negative Regulation Of B Cell Activation Regulation Of Regulated Secretory Pathway B Cell Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Adhesion Mediated By Integrin One-carbon Metabolic Process Regulation Of Bone Remodeling Monovalent Inorganic Cation Transport Inorganic Anion Transport Regulation Of Immune System Process Immune System Process Homeostatic Process Regulation Of T Cell Activation	Bicarbonate Transport Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of PH Inorganic Anion Transport Anion Transmembrane Transport Organic Anion Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Anion Transport Chloride Transmembrane Transport Cellular Homeostasis Chloride Transport Chemical Homeostasis Box C/D SnoRNP Assembly Ion Transmembrane Transport Homeostatic Process Transmembrane Transport Ion Transport Hydrogen Peroxide Catabolic Process Removal Of Superoxide Radicals Cellular Response To Superoxide Response To Superoxide Response To Oxygen Radical Hydrogen Peroxide Metabolic Process Superoxide Metabolic Process Cellular Response To Reactive Oxygen Species
Tagcloud ?		acidosis ae1 anion bicarbonate calnexin cotranslationally destination exchanger folded folding glycoproteins glycosylated hereditary interfere kae1 misfolded monitors ovalocytosis properly retrotranslocation slc26 southeast spherocytosis summarizes traffic trafficking transporters ubiquitinylation	adrenal adrenalectomy adx alteration animals autoradiography ca1 decreased dentate hippocampus histochemistry hormones hybridization igf influenced insulin level like long mrna noted receptor receptors regions situ studied suggesting term vitro
Tagcloud (Difference) ?		acidosis ae1 anion bicarbonate calnexin cotranslationally destination exchanger folded folding glycoproteins glycosylated hereditary interfere kae1 misfolded monitors ovalocytosis properly retrotranslocation slc26 southeast spherocytosis summarizes traffic trafficking transporters ubiquitinylation	adrenal adrenalectomy adx alteration animals autoradiography ca1 decreased dentate hippocampus histochemistry hormones hybridization igf influenced insulin level like long mrna noted receptor receptors regions situ studied suggesting term vitro
Tagcloud (Intersection) ?