TCF7 and UCHL5

Number of citations of the paper that reports this interaction (PubMedID 28198400)
62

Data Source:
BioGRID (enzymatic study)

		TCF7	UCHL5
Description		transcription factor 7	ubiquitin C-terminal hydrolase L5
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body Beta-catenin-TCF Complex	Proteasome Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ino80 Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity DNA Binding Protein Binding Beta-catenin Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteasome Binding
	Biological Process	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Immune Response Wnt Signaling Pathway Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of DNA-templated Transcription Canonical Wnt Signaling Pathway Cellular Response To Interleukin-4	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Proteolysis Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Deubiquitination Lateral Ventricle Development Midbrain Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes RUNX3 regulates WNT signaling Germ layer formation at gastrulation Formation of axial mesoderm Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Regulation of PD-L1(CD274) transcription	Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Menarche (age at onset) ( 25231870) Multiple sclerosis ( 21833088 24076602 31604244) Rheumatoid arthritis ( 32868391) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 27399966 28714469 33272962) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Cannabis dependence ( 21668797)
Interacting Genes		3 interacting genes: NHERF2 SS18L1 UCHL5	104 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 AXIN1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA OGT PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL RNF4 S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1
Entrez ID		6932	51377
HPRD ID		01797	10293
Ensembl ID		ENSG00000081059	ENSG00000116750
Uniprot IDs		B3KQ75 P36402	Q5LJA5 Q9Y5K5
PDB IDs			3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP
Enriched GO Terms of Interacting Partners?			CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Extracellular Exosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromatin Nucleosome Assembly Cornified Envelope Nucleosome Organization Structural Constituent Of Chromatin Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Nucleosome Protein-DNA Complex Assembly Telomere Organization Protein-containing Complex Chromosome, Telomeric Region Negative Regulation Of Cell Differentiation Intermediate Filament Organization Chromatin Remodeling Regulation Of Myeloid Cell Differentiation Structural Constituent Of Skin Epidermis Regulation Of Hemopoiesis Chromatin Organization Extracellular Region Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Negative Regulation Of Developmental Process Desmosome Regulation Of Cell Development Organelle Organization Peptide Cross-linking Regulation Of Cell Differentiation Protein Heterodimerization Activity Intermediate Filament Keratin Filament Keratinocyte Differentiation Supramolecular Fiber Organization Protein Localization To Organelle RNA Binding Chromosome Organization Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Regulation Of Multicellular Organismal Process Nucleus Regulation Of Immune System Process Epidermal Cell Differentiation Haptoglobin Binding
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