TCF7

Name	transcription factor 7
Structure	No pdb structure
Novel Interactors	2 novel interactors: GOLGA3 JADE2
Interactors	3 interactors: NHERF2 SS18L1 UCHL5
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body Beta-catenin-TCF Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity DNA Binding Protein Binding Beta-catenin Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Immune Response Wnt Signaling Pathway Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of DNA-templated Transcription Canonical Wnt Signaling Pathway Cellular Response To Interleukin-4
Pathways	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes RUNX3 regulates WNT signaling Germ layer formation at gastrulation Formation of axial mesoderm Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Regulation of PD-L1(CD274) transcription
GWAS	Autoimmune thyroid disease ( 32581359 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Medication use (thyroid preparations) ( 31015401 ) Menarche (age at onset) ( 25231870 ) Multiple sclerosis ( 21833088 24076602 31604244 ) Rheumatoid arthritis ( 32868391 ) Sum eosinophil basophil counts ( 27863252 ) Systemic lupus erythematosus ( 26502338 27399966 28714469 33272962 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Entrez ID	6932
HPRD ID	01797
Ensembl ID	ENSG00000081059
Uniprot IDs	B3KQ75 P36402
PDB IDs	Not available