TCF7

Gene Name		transcription factor 7 (T-cell specific, HMG-box)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Beta-catenin Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Immune Response Brain Development Neural Tube Development Embryonic Genitalia Morphogenesis T Cell Receptor V(D)J Recombination Regulation Of Cell Proliferation Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Alpha-beta T Cell Differentiation Embryonic Digestive Tract Morphogenesis Embryonic Hindgut Morphogenesis Generation Of Neurons Canonical Wnt Signaling Pathway Cellular Response To Interleukin-4
Pathways		APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt binding of TCF/LEF:CTNNB1 to target gene promoters deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes beta-catenin independent WNT signaling deletions in the AMER1 gene destabilize the destruction complex Ca2+ pathway TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-protein Interactions		1 interactors: SS18L1
Entrez ID		6932
HPRD ID		01797
Ensembl ID		ENSG00000081059
Uniprot IDs		P36402
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?		alkaline antagonist blotting catenin dickkopf dkk1 e1 enhancer explored immunofluorescence lef1 lymphocyte mc3t3 myc neurokinin nk1 osteoblast osteoblastic osteoblasts osteocalcin osteogenesis osteogenic promoted ranging runx2 sp substance unravel wnt