TCF7 and SS18L1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		TCF7	SS18L1
Gene Name		transcription factor 7 (T-cell specific, HMG-box)	synovial sarcoma translocation gene on chromosome 18-like 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome, Centromeric Region Nucleus Nuclear Body NBAF Complex
	Molecular Function	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Beta-catenin Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Immune Response Brain Development Neural Tube Development Embryonic Genitalia Morphogenesis T Cell Receptor V(D)J Recombination Regulation Of Cell Proliferation Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Alpha-beta T Cell Differentiation Embryonic Digestive Tract Morphogenesis Embryonic Hindgut Morphogenesis Generation Of Neurons Canonical Wnt Signaling Pathway Cellular Response To Interleukin-4	Transcription, DNA-templated Dendrite Development Chromatin Modification Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Dendrite Morphogenesis
Pathways		APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt binding of TCF/LEF:CTNNB1 to target gene promoters deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes beta-catenin independent WNT signaling deletions in the AMER1 gene destabilize the destruction complex Ca2+ pathway TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-Protein Interactions		1 interactors: SS18L1	30 interactors: AATF ANKRD22 ATF3 BRD1 CREBBP CSTF2 CTAGE5 DGCR6 ELF5 EP300 FAM168A GATAD1 HDAC2 HDAC4 LGALS3 MAPK1IP1L MED30 NR1H3 PCGF6 RFX6 RLIM SF3B4 SMAD1 SMAD3 SMARCA4 SNRPB SNRPC STAT3 TAF9B TCF7
Entrez ID		6932	26039
HPRD ID		01797	09398
Ensembl ID		ENSG00000081059	ENSG00000184402
Uniprot IDs		P36402	B4DSR7 O75177
PDB IDs
Enriched GO Terms of Interacting Partners?			RNA Metabolic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Cell Differentiation Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Epithelium Development RNA Processing Histone Modification N-terminal Peptidyl-lysine Acetylation DNA-templated Transcription, Initiation Gene Silencing Cellular Metabolic Process Negative Regulation Of Cell Death Histone Acetylation Peptidyl-lysine Modification Tissue Development Internal Peptidyl-lysine Acetylation
Tagcloud ?		alkaline antagonist blotting catenin dickkopf dkk1 e1 enhancer explored immunofluorescence lef1 lymphocyte mc3t3 myc neurokinin nk1 osteoblast osteoblastic osteoblasts osteocalcin osteogenesis osteogenic promoted ranging runx2 sp substance unravel wnt	acetyl allantoic brg1 chorio crest embryos ini1 interbreeding knockout lethal linearities peroxisome phenotype placental pparbp proliferator recessive resembles sarcoma snf ssxt structurally swi synergistically synovial syt transferase vascularization
Tagcloud (Difference) ?		alkaline antagonist blotting catenin dickkopf dkk1 e1 enhancer explored immunofluorescence lef1 lymphocyte mc3t3 myc neurokinin nk1 osteoblast osteoblastic osteoblasts osteocalcin osteogenesis osteogenic promoted ranging runx2 sp substance unravel wnt	acetyl allantoic brg1 chorio crest embryos ini1 interbreeding knockout lethal linearities peroxisome phenotype placental pparbp proliferator recessive resembles sarcoma snf ssxt structurally swi synergistically synovial syt transferase vascularization
Tagcloud (Intersection) ?