TBP and NR3C1

Number of citations of the paper that reports this interaction (PMID 9649342)
19

Data Source:
HPRD (in vivo)

		TBP	NR3C1
Gene Name		TATA box binding protein	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
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Gene Ontology Annotations	Cellular Component	Female Pronucleus Male Pronucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Nuclear Euchromatin Cytoplasm	Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Membrane
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding Repressing Transcription Factor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Glucocorticoid Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Glucocorticoid-activated RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Protein Dimerization Activity Steroid Hormone Binding
	Biological Process	Chromatin Silencing At RDNA Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Transcription From RNA Polymerase III Promoter Spermatogenesis Gene Expression Viral Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated	Regulation Of Gluconeogenesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Glucocorticoid Metabolic Process Gene Expression Chromatin Modification Adrenal Gland Development Regulation Of Glucocorticoid Biosynthetic Process Maternal Behavior Glucocorticoid Receptor Signaling Pathway Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Duct Morphogenesis Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Glucocorticoid Mediated Signaling Pathway
Pathways		RNA Polymerase II Promoter Escape RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection RNA Polymerase II Pre-transcription Events HIV Life Cycle HIV Transcription Initiation NoRC negatively regulates rRNA expression RNA Polymerase II HIV Promoter Escape RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation SIRT1 negatively regulates rRNA Expression Transcription of the HIV genome	BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs			Flunisolide Diflorasone Alclometasone Medrysone Amcinonide Fluorometholone Megestrol Beclometasone dipropionate Betamethasone Desoximetasone Fluticasone Propionate Fluocinolone Acetonide Halobetasol Propionate Triamcinolone Prednisone Flumethasone Pivalate Fludrocortisone Hydrocortisone Mometasone Hydrocortamate Mifepristone Clocortolone Flurandrenolide Prednisolone Loteprednol Rimexolone Methylprednisolone Clobetasol Fluocinonide Prednicarbate Fluoxymesterone Budesonide Dexamethasone Desonide Cortisone acetate Paramethasone Ciclesonide Hexane-1,6-Diol Difluprednate Fluticasone furoate
Diseases
GWAS		Type 1 diabetes ( 21980299)
Protein-Protein Interactions		113 interactors: ABT1 AHR AR ATF4 BCL3 BRD2 BRF1 BRF2 BTAF1 CAND2 CITED2 COL26A1 CREG1 CREM CTBP1 CTD CXXC1 DHX9 DR1 DRAP1 E2F1 EDF1 ELF3 ESR1 FATE1 FOS FOXF2 GOLGA2 GTF2A1 GTF2A1L GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H4 GTF3C2 GTF3C3 GTF3C4 GTF3C5 HAP1 HIST3H3 HMGB1 HNF4A HNRNPK HSF1 HTT IKZF1 JUN JUND KDM5A KLF5 MCM2 MDM2 MSX1 MYC NACA NCOA1 NCOA3 NCOA6 NFYB NFYC NR3C1 PAX3 PAX5 PAX6 PIAS1 PIAS3 POLR2A POLR3F POU2F1 POU2F2 POU3F2 PSMC2 RB1 REL RELA REST RNF4 RUVBL1 RUVBL2 RXRA SNAPC1 SNAPC2 SNAPC4 SP1 SPI1 SPIB SSX2IP SUB1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF1B TAF1C TAF1L TAF5 TAF7L TCF12 TEAD1 TP53 TRAM2 TRIP4 UBE2I UBTF WDR62 YWHAE ZNF76	135 interactors: ADA AR ARPC5 BAG1 CALM1 CALR CEBPA CEBPB CENPB CHD9 COPS6 CREB1 CREBBP DAP3 DAXX DCAF6 DDX54 ECD ETS1 ETS2 FKBP4 FTH1 FYN GNB1 GNB2 GNB2L1 GRIP1 HDAC6 HMGB1 HMGB2 HMOX2 HNRNPA1 HNRNPU HSP90AA1 HSPA1A HSPD1 IDE IFNGR2 JUN KAT5 KDM5A KPNA2 LCK LRIF1 MAFF MAPK1 MAPK15 MAPK8 MDM2 MED1 MED14 MED25 MSX2 NCL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NEDD4L NFKB1 NFKB2 NR0B1 NR1H3 NR2E3 NR2F2 NR2F6 NR3C2 NR4A1 NRIP1 ONECUT1 OSGEP PBX1 PELP1 PIAS2 PML POLR1D POU1F1 POU2F1 POU2F2 PPARGC1A PRKACA PRKDC PRPF6 PSMC3IP PTGES3 PTMS RAD54L2 RAD9A RAF1 RAN RARA RBM14 RELA RNF14 RXRB SFN SLC25A4 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCD1 SMARCE1 SRA1 SRC STAT3 STAT5A STAT5B SUMO1 SUMO4 SVIL SYT1 TADA2A TBP TDG TGFB1I1 TMF1 TP53 TRIM24 TRIM28 TSG101 TXN UBB UBE2I UBE2L3 YWHAH ZBTB16 ZBTB20 ZBTB3 ZBTB9 ZNF496
Entrez ID		6908	2908
HPRD ID		02511	00679
Ensembl ID		ENSG00000112592	ENSG00000113580
Uniprot IDs		P20226 Q32MN6 Q32MN7	B7Z7I2 E5KQF5 E5KQF6 F1D8N4 P04150
PDB IDs		1C9B 1CDW 1JFI 1NVP 1TGH	1M2Z 1NHZ 1P93 3BQD 3CLD 3E7C 3H52 3K22 3K23 4HN5 4HN6
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Aromatic Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Biosynthetic Process Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Cellular Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Viral Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Metabolic Process Chromosome Organization Chromatin Organization Chromatin Modification Transcription From RNA Polymerase III Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Histone Acetylation Internal Peptidyl-lysine Acetylation	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Gene Expression RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Cellular Metabolic Process Cellular Response To Hormone Stimulus Biosynthetic Process Regulation Of Cellular Process Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Androgen Receptor Signaling Pathway Response To Steroid Hormone Response To Organic Cyclic Compound Transcription Initiation From RNA Polymerase II Promoter Response To Lipid DNA-templated Transcription, Initiation Cell Differentiation
Tagcloud ?		60s analyzing cerevisiae codons defect efficiently encodes facilitates fflux firefly gfp homologue hsp70 inducible modest mutant polysome polysomes rarely saccharomyces strain surprisingly tata translated translation turnover ydj1 ydj1p yeast	2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii
Tagcloud (Difference) ?		60s analyzing cerevisiae codons defect efficiently encodes facilitates fflux firefly gfp homologue hsp70 inducible modest mutant polysome polysomes rarely saccharomyces strain surprisingly tata translated translation turnover ydj1 ydj1p yeast	2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii
Tagcloud (Intersection) ?