TBP and POU2F1

Number of citations of the paper that reports this interaction (PMID 8202368)
20

Data Source:
HPRD (in vitro, in vivo)

		TBP	POU2F1
Gene Name		TATA box binding protein	POU class 2 homeobox 1
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Gene Ontology Annotations	Cellular Component	Female Pronucleus Male Pronucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Nuclear Euchromatin Cytoplasm	Nucleus Nucleoplasm Transcription Factor Complex Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding Repressing Transcription Factor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Chromatin Silencing At RDNA Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Transcription From RNA Polymerase III Promoter Spermatogenesis Gene Expression Viral Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated	Transcription From RNA Polymerase III Promoter Gene Expression Olfactory Placode Formation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lens Induction In Camera-type Eye
Pathways		RNA Polymerase II Promoter Escape RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection RNA Polymerase II Pre-transcription Events HIV Life Cycle HIV Transcription Initiation NoRC negatively regulates rRNA expression RNA Polymerase II HIV Promoter Escape RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation SIRT1 negatively regulates rRNA Expression Transcription of the HIV genome	RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Type 1 diabetes ( 21980299)	Liver enzyme levels ( 18940312)
Protein-Protein Interactions		113 interactors: ABT1 AHR AR ATF4 BCL3 BRD2 BRF1 BRF2 BTAF1 CAND2 CITED2 COL26A1 CREG1 CREM CTBP1 CTD CXXC1 DHX9 DR1 DRAP1 E2F1 EDF1 ELF3 ESR1 FATE1 FOS FOXF2 GOLGA2 GTF2A1 GTF2A1L GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H4 GTF3C2 GTF3C3 GTF3C4 GTF3C5 HAP1 HIST3H3 HMGB1 HNF4A HNRNPK HSF1 HTT IKZF1 JUN JUND KDM5A KLF5 MCM2 MDM2 MSX1 MYC NACA NCOA1 NCOA3 NCOA6 NFYB NFYC NR3C1 PAX3 PAX5 PAX6 PIAS1 PIAS3 POLR2A POLR3F POU2F1 POU2F2 POU3F2 PSMC2 RB1 REL RELA REST RNF4 RUVBL1 RUVBL2 RXRA SNAPC1 SNAPC2 SNAPC4 SP1 SPI1 SPIB SSX2IP SUB1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF1B TAF1C TAF1L TAF5 TAF7L TCF12 TEAD1 TP53 TRAM2 TRIP4 UBE2I UBTF WDR62 YWHAE ZNF76	50 interactors: AES APP AR BARD1 BRCA1 CEBPE CREB1 EPRS ESR1 FDXR HCFC1 HMGA1 HMGB2 HNF1A HOXB13 HOXC9 IRF9 LIFR MNAT1 MSX1 NCOR2 NFYA NPAT NR3C1 PARP1 PBX1 PGR PKNOX1 PLK3 POGZ POU2AF1 PRKACA PRKDC RARA RELA RXRA SNAPC4 SOX2 SP1 SP4 STAT5A STAT5B TBP THRA TLE4 TLX2 TNF TXNRD1 VDR XRCC6
Entrez ID		6908	5451
HPRD ID		02511	01250
Ensembl ID		ENSG00000112592	ENSG00000143190
Uniprot IDs		P20226 Q32MN6 Q32MN7	J3KP77 P14859
PDB IDs		1C9B 1CDW 1JFI 1NVP 1TGH	1CQT 1E3O 1GT0 1HF0 1O4X 1OCT 1POG 1POU
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Aromatic Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Biosynthetic Process Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Cellular Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Viral Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Metabolic Process Chromosome Organization Chromatin Organization Chromatin Modification Transcription From RNA Polymerase III Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Histone Acetylation Internal Peptidyl-lysine Acetylation	Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Gland Development Negative Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organ Development Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Response To Hormone DNA-templated Transcription, Initiation Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Response To Steroid Hormone Organ Morphogenesis Reproductive Process Hormone-mediated Signaling Pathway Anatomical Structure Morphogenesis Intracellular Receptor Signaling Pathway Multicellular Organismal Development System Development
Tagcloud ?		60s analyzing cerevisiae codons defect efficiently encodes facilitates fflux firefly gfp homologue hsp70 inducible modest mutant polysome polysomes rarely saccharomyces strain surprisingly tata translated translation turnover ydj1 ydj1p yeast	build built compendium connected controlling databases delineate deoxyribonuclease encode experimentally footprinting gata3 hnf1b hypersensitivity klf4 locations matrices motifs orthologs rarb runx2 rxra silico smad3 sp1 sp3 umod upstream uromodulin
Tagcloud (Difference) ?		60s analyzing cerevisiae codons defect efficiently encodes facilitates fflux firefly gfp homologue hsp70 inducible modest mutant polysome polysomes rarely saccharomyces strain surprisingly tata translated translation turnover ydj1 ydj1p yeast	build built compendium connected controlling databases delineate deoxyribonuclease encode experimentally footprinting gata3 hnf1b hypersensitivity klf4 locations matrices motifs orthologs rarb runx2 rxra silico smad3 sp1 sp3 umod upstream uromodulin
Tagcloud (Intersection) ?