TBP and MBD2

Number of citations of the paper that reports this interaction (PubMedID 25363021)
38

Data Source:
BioGRID (pull down)

		TBP	MBD2
Description		TATA-box binding protein	methyl-CpG binding domain protein 2
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GO Annotations	Cellular Component	Chromatin Euchromatin Male Germ Cell Nucleus Female Germ Cell Nucleus Female Pronucleus Male Pronucleus Nucleus Nucleoplasm RNA Polymerase Transcription Factor SL1 Complex Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Cytoplasm Cytosol Protein-containing Complex Pronucleus	Histone Deacetylase Complex Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol NuRD Complex Protein-containing Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase III General Transcription Initiation Factor Activity Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding TFIIB-class Transcription Factor Binding RNA Polymerase I Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Aryl Hydrocarbon Receptor Binding Enzyme Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding	DNA Binding Chromatin Binding Satellite DNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Protein Domain Specific Binding Nucleosomal DNA Binding SiRNA Binding Identical Protein Binding Molecular Adaptor Activity C2H2 Zinc Finger Domain Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly DNA-templated Transcription Initiation Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription By RNA Polymerase III Spermatogenesis MRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Ventricular Cardiac Muscle Tissue Development Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Response To Mechanical Stimulus Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Response To Nutrient Levels Response To Estradiol Epigenetic Regulation Of Gene Expression Regulation Of Cell Population Proliferation Maternal Behavior Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Protein-containing Complex Assembly Response To Bisphenol A Cellular Response To Serotonin
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter Estrogen-dependent gene expression	NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Type 1 diabetes ( 21980299)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Body size at age 10 ( 32376654) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Nickel levels ( 26025379) Periodontitis (Mean PAL) ( 24024966) Prostate cancer ( 29892016) Psoriasis ( 23143594)
Interacting Genes		119 interacting genes: ABT1 AHR AR ATF4 BCL3 BRF1 BRF2 BTAF1 CAND2 CFTR CITED2 COL26A1 CREG1 CREM CTBP1 CTCFL CXXC1 DHX9 DR1 DRAP1 E2F1 EDF1 ELF3 ESR1 ETS1 FATE1 FOS FOXF2 GOLGA2 GTF2A1 GTF2A1L GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F2 GTF2H4 GTF3C2 GTF3C3 GTF3C4 GTF3C5 H3-4 HAP1 HMBOX1 HMGB1 HNF4A HNRNPK HSF1 HTT HUWE1 IKZF1 JUN JUND JUP KDM5A KLF5 MBD2 MCM2 MDM2 MSX1 MYC NACA NCAPH NCOA1 NCOA3 NCOA6 NFE2L2 NFYB NFYC NR3C1 PAX3 PAX5 PAX6 PIAS1 PIAS3 POLR3F POU2F1 POU2F2 POU3F2 PSMC2 RB1 REL RELA REST RNF4 RUVBL1 RUVBL2 RXRA SERPINB5 SNAPC1 SNAPC2 SNAPC4 SP1 SPI1 SPIB SSX2IP SUB1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF1A TAF1B TAF1C TAF1L TAF5 TAF7L TCF12 TEAD1 TP53 TRAM2 TRIP4 UBE2I UBTF WDR62 YEATS2 YWHAE ZNF76	21 interacting genes: BEND7 C1QBP CREBBP DHX9 GATAD2A GATAD2B GPN1 HDAC1 HDAC2 HINFP LAMTOR3 MBD3 MBD3L1 MBD3L2 PRMT1 PURB RALYL RBBP4 SIN3A SMN2 TBP
Entrez ID		6908	8932
HPRD ID		02511	04647
Ensembl ID		ENSG00000112592	ENSG00000134046
Uniprot IDs		P20226 Q32MN7	Q9UBB5
PDB IDs		1C9B 1CDW 1JFI 1NVP 1TGH 4ROC 4ROD 4ROE 5FUR 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5N9G 6MZD 6MZL 6MZM 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGI 7EGJ 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWC 7ZWD 7ZX7 7ZX8 7ZXE 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8ITY 8IUE 8IUH 8S51 8S52 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS 9FSO 9FSP 9FSQ 9FSR 9FSS	2L2L 6C1A 6C1T 6C1U 6C1V 6C2F 6CNP 6CNQ 7AO8 7AO9 7AOA 7MWK 7MWM 7RAY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-templated Transcription DNA Binding Positive Regulation Of RNA Metabolic Process Nucleoplasm TBP-class Protein Binding Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process DNA-templated Transcription Initiation Regulation Of Primary Metabolic Process RNA Metabolic Process Chromatin Nucleic Acid Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Regulator Complex Transcription Preinitiation Complex Assembly Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Factor TFIID Complex Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Initiation At RNA Polymerase II Promoter RNA Polymerase II-specific DNA-binding Transcription Factor Binding RNA Polymerase II Preinitiation Complex Assembly RNA Polymerase II Core Promoter Sequence-specific DNA Binding	NuRD Complex Regulation Of Cell Fate Specification Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Fate Commitment Chromatin Organization Negative Regulation Of RNA Metabolic Process Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Stem Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Nucleosomal DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sin3-type Complex Heterochromatin Formation Negative Regulation Of Gene Expression Negative Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Methyl-CpG Binding Negative Regulation Of Gene Expression, Epigenetic Regulation Of RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Complex Positive Regulation Of Stem Cell Population Maintenance Nucleoplasm Nucleus Constitutive Heterochromatin Formation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Biosynthetic Process Protein-containing Complex Regulation Of Stem Cell Population Maintenance DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Protein Lysine Delactylase Activity Fungiform Papilla Formation
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