TBP and RUVBL1

Number of citations of the paper that reports this interaction (PMID 9843967)
41

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		TBP	RUVBL1
Gene Name		TATA box binding protein	RuvB-like AAA ATPase 1
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Gene Ontology Annotations	Cellular Component	Female Pronucleus Male Pronucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Nuclear Euchromatin Cytoplasm	Swr1 Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Microtubule Organizing Center Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome MLL1 Complex
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding Repressing Transcription Factor Binding	DNA Helicase Activity Protein Binding ATP Binding ATPase Activity
	Biological Process	Chromatin Silencing At RDNA Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Transcription From RNA Polymerase III Promoter Spermatogenesis Gene Expression Viral Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated	DNA Repair DNA Recombination Chromatin Organization Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Nuclear Division Spermatogenesis DNA Duplex Unwinding CENP-A Containing Nucleosome Assembly Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Cell Division
Pathways		RNA Polymerase II Promoter Escape RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection RNA Polymerase II Pre-transcription Events HIV Life Cycle HIV Transcription Initiation NoRC negatively regulates rRNA expression RNA Polymerase II HIV Promoter Escape RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation SIRT1 negatively regulates rRNA Expression Transcription of the HIV genome	Chromosome Maintenance Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex Deposition of new CENPA-containing nucleosomes at the centromere Telomere Extension By Telomerase Extension of Telomeres Signaling by Wnt HATs acetylate histones Chromatin modifying enzymes Telomere Maintenance Nucleosome assembly TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer
Drugs
Diseases
GWAS		Type 1 diabetes ( 21980299)
Protein-Protein Interactions		113 interactors: ABT1 AHR AR ATF4 BCL3 BRD2 BRF1 BRF2 BTAF1 CAND2 CITED2 COL26A1 CREG1 CREM CTBP1 CTD CXXC1 DHX9 DR1 DRAP1 E2F1 EDF1 ELF3 ESR1 FATE1 FOS FOXF2 GOLGA2 GTF2A1 GTF2A1L GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H4 GTF3C2 GTF3C3 GTF3C4 GTF3C5 HAP1 HIST3H3 HMGB1 HNF4A HNRNPK HSF1 HTT IKZF1 JUN JUND KDM5A KLF5 MCM2 MDM2 MSX1 MYC NACA NCOA1 NCOA3 NCOA6 NFYB NFYC NR3C1 PAX3 PAX5 PAX6 PIAS1 PIAS3 POLR2A POLR3F POU2F1 POU2F2 POU3F2 PSMC2 RB1 REL RELA REST RNF4 RUVBL1 RUVBL2 RXRA SNAPC1 SNAPC2 SNAPC4 SP1 SPI1 SPIB SSX2IP SUB1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF1B TAF1C TAF1L TAF5 TAF7L TCF12 TEAD1 TP53 TRAM2 TRIP4 UBE2I UBTF WDR62 YWHAE ZNF76	20 interactors: ACTL6A CTNNB1 DKC1 FBL HDAC1 KIAA1377 LZTR1 MRGBP MYC NEDD4 NUFIP1 OFD1 PIH1D1 PLG RUVBL2 STOM TAF9 TBP TERT TK1
Entrez ID		6908	8607
HPRD ID		02511	09143
Ensembl ID		ENSG00000112592	ENSG00000175792
Uniprot IDs		P20226 Q32MN6 Q32MN7	Q9Y265
PDB IDs		1C9B 1CDW 1JFI 1NVP 1TGH	2C9O 2XSZ
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Aromatic Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Biosynthetic Process Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Cellular Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Viral Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Metabolic Process Chromosome Organization Chromatin Organization Chromatin Modification Transcription From RNA Polymerase III Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Histone Acetylation Internal Peptidyl-lysine Acetylation	Chromatin Modification Chromosome Organization Chromatin Organization Organelle Organization RNA Metabolic Process Box C/D SnoRNP Assembly Nucleobase-containing Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Histone Modification Chromatin Remodeling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Cellular Response To UV Cellular Nitrogen Compound Metabolic Process Fungiform Papilla Formation Gene Expression Negative Regulation Of Signaling Telomere Maintenance Via Telomerase DNA-templated Transcription, Initiation Fungiform Papilla Morphogenesis Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Fungiform Papilla Development RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Light Stimulus Developmental Process Nitrogen Compound Metabolic Process Histone H2A Acetylation Hair Follicle Placode Formation Cellular Component Assembly Tongue Morphogenesis DNA Biosynthetic Process Histone Acetylation Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Internal Peptidyl-lysine Acetylation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation RNA-dependent DNA Replication Protein Acetylation Response To UV Regulation Of Transcription, DNA-templated
Tagcloud ?		60s analyzing cerevisiae codons defect efficiently encodes facilitates fflux firefly gfp homologue hsp70 inducible modest mutant polysome polysomes rarely saccharomyces strain surprisingly tata translated translation turnover ydj1 ydj1p yeast	anaemia aplastic assemble atpases conditional confers core crosslinker crosslinks depletion encode fa fanconi haematopoietic hallmark instability interstrand lethal monoubiquitin multisubunit pool profound purify repairs senses stringent surprisingly vertebrate
Tagcloud (Difference) ?		60s analyzing cerevisiae codons defect efficiently encodes facilitates fflux firefly gfp homologue hsp70 inducible modest mutant polysome polysomes rarely saccharomyces strain tata translated translation turnover ydj1 ydj1p yeast	anaemia aplastic assemble atpases conditional confers core crosslinker crosslinks depletion encode fa fanconi haematopoietic hallmark instability interstrand lethal monoubiquitin multisubunit pool profound purify repairs senses stringent vertebrate
Tagcloud (Intersection) ?		surprisingly