TBP and KDM5A

Number of citations of the paper that reports this interaction (PubMedID 7935440)
57

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		TBP	KDM5A
Description		TATA-box binding protein	lysine demethylase 5A
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GO Annotations	Cellular Component	Chromatin Euchromatin Male Germ Cell Nucleus Female Germ Cell Nucleus Female Pronucleus Male Pronucleus Nucleus Nucleoplasm RNA Polymerase Transcription Factor SL1 Complex Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Cytoplasm Cytosol Protein-containing Complex Pronucleus	Chromatin Nucleus Nucleoplasm Nucleolus Protein-DNA Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase III General Transcription Initiation Factor Activity Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding TFIIB-class Transcription Factor Binding RNA Polymerase I Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Aryl Hydrocarbon Receptor Binding Enzyme Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Enzyme Inhibitor Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity Histone H3K4 Demethylase Activity Histone H3K4me/H3K4me2/H3K4me3 Demethylase Activity Histone Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly DNA-templated Transcription Initiation Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription By RNA Polymerase III Spermatogenesis MRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Circadian Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of DNA-binding Transcription Factor Activity Facultative Heterochromatin Formation
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter Estrogen-dependent gene expression	HDMs demethylate histones Chromatin modifications during the maternal to zygotic transition (MZT)
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Type 1 diabetes ( 21980299)	Body mass index ( 26426971) Pulse pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Interacting Genes		119 interacting genes: ABT1 AHR AR ATF4 BCL3 BRF1 BRF2 BTAF1 CAND2 CFTR CITED2 COL26A1 CREG1 CREM CTBP1 CTCFL CXXC1 DHX9 DR1 DRAP1 E2F1 EDF1 ELF3 ESR1 ETS1 FATE1 FOS FOXF2 GOLGA2 GTF2A1 GTF2A1L GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F2 GTF2H4 GTF3C2 GTF3C3 GTF3C4 GTF3C5 H3-4 HAP1 HMBOX1 HMGB1 HNF4A HNRNPK HSF1 HTT HUWE1 IKZF1 JUN JUND JUP KDM5A KLF5 MBD2 MCM2 MDM2 MSX1 MYC NACA NCAPH NCOA1 NCOA3 NCOA6 NFE2L2 NFYB NFYC NR3C1 PAX3 PAX5 PAX6 PIAS1 PIAS3 POLR3F POU2F1 POU2F2 POU3F2 PSMC2 RB1 REL RELA REST RNF4 RUVBL1 RUVBL2 RXRA SERPINB5 SNAPC1 SNAPC2 SNAPC4 SP1 SPI1 SPIB SSX2IP SUB1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF1A TAF1B TAF1C TAF1L TAF5 TAF7L TCF12 TEAD1 TP53 TRAM2 TRIP4 UBE2I UBTF WDR62 YEATS2 YWHAE ZNF76	14 interacting genes: CCT6A DSCR9 ESR1 H3-4 H3C1 H3C15 LMO2 NR3C1 RARA RB1 RBL1 RNF10 TBP VDR
Entrez ID		6908	5927
HPRD ID		02511	08915
Ensembl ID		ENSG00000112592	ENSG00000073614
Uniprot IDs		P20226 Q32MN7	P29375
PDB IDs		1C9B 1CDW 1JFI 1NVP 1TGH 4ROC 4ROD 4ROE 5FUR 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5N9G 6MZD 6MZL 6MZM 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGI 7EGJ 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWC 7ZWD 7ZX7 7ZX8 7ZXE 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8ITY 8IUE 8IUH 8S51 8S52 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS 9FSO 9FSP 9FSQ 9FSR 9FSS	2JXJ 2KGG 2KGI 3GL6 5C11 5CEH 5E6H 5ISL 5IVB 5IVC 5IVE 5IVF 5IVJ 5IVV 5IVY 5IW0 5IWF 5K4L 5V9P 5V9T 6BGU 6BGV 6BGW 6BGX 6BGY 6BGZ 6BH0 6BH1 6BH2 6BH3 6BH4 6BH5 6DQ4 6DQ5 6DQ6 6DQ7 6DQ8 6DQ9 6DQA 6DQB 6DQC 6DQD 6DQE 6DQF 7KLO 7KLR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-templated Transcription DNA Binding Positive Regulation Of RNA Metabolic Process Nucleoplasm TBP-class Protein Binding Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process DNA-templated Transcription Initiation Regulation Of Primary Metabolic Process RNA Metabolic Process Chromatin Nucleic Acid Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Regulator Complex Transcription Preinitiation Complex Assembly Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Factor TFIID Complex Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Initiation At RNA Polymerase II Promoter RNA Polymerase II-specific DNA-binding Transcription Factor Binding RNA Polymerase II Preinitiation Complex Assembly RNA Polymerase II Core Promoter Sequence-specific DNA Binding	DNA Binding Nuclear Receptor Activity Protein-DNA Complex Assembly Chromatin Transcription Regulator Complex Nuclear Receptor-mediated Signaling Pathway TFIIB-class Transcription Factor Binding Mammary Gland Branching Involved In Pregnancy Transcription By RNA Polymerase II Chromatin Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Lipid Kinase Activity Nucleoplasm Regulation Of Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Estrogen Response Element Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Structural Constituent Of Chromatin Regulation Of MiRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Cellular Response To Estrogen Stimulus Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Core Promoter Sequence-specific DNA Binding Nucleosome Assembly Branching Involved In Mammary Gland Duct Morphogenesis Nucleosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Steroid Receptor Activity
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